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Oseltamivir-resistant pandemic (H1N1) 2009 virus, Mexico.

Ramirez-Gonzalez, José Ernesto; Gonzalez-Duran, Elizabeth; Alcantara-Perez, Patricia; Wong-Arambula, Claudia; Olivera-Diaz, Hiram; Cortez-Ortiz, Iliana; Barrera-Badillo, Gisela; Nguyen, Ha; Gubareva, Larisa; Lopez-Martinez, Irma; Díaz-Quiñonez, Jose Alberto; Lezana-Fernández, Miguel Angel; Gatell-Ramírez, Hugo Lopez; Cordova Villalobos, Jose Angel; Hernández-Avila, Mauricio; Alpuche-Aranda, Celia.

Emerg Infect Dis ; 17(2): 283-6, 2011 Feb.

Article in English | MEDLINE | ID: mdl-21291607

ABSTRACT

During May 2009-April 2010, we analyzed 692 samples of pandemic (H1N1) 2009 virus from patients in Mexico. We detected the H275Y substitution of the neuraminidase gene in a specimen from an infant with pandemic (H1N1) 2009 who was treated with oseltamivir. This virus was susceptible to zanamivir and resistant to adamantanes and oseltamivir.

Subject(s)

Antiviral Agents/pharmacology , Drug Resistance, Viral , Influenza A Virus, H1N1 Subtype/drug effects , Influenza, Human/epidemiology , Influenza, Human/prevention & control , Oseltamivir/pharmacology , Pandemics , Adamantane/pharmacology , Antiviral Agents/administration & dosage , Antiviral Agents/therapeutic use , Drug Resistance, Viral/genetics , Female , Humans , Infant , Influenza A Virus, H1N1 Subtype/genetics , Influenza A Virus, H1N1 Subtype/isolation & purification , Influenza, Human/drug therapy , Mexico/epidemiology , Microbial Sensitivity Tests , Neuraminidase/antagonists & inhibitors , Neuraminidase/genetics , Oseltamivir/administration & dosage , Oseltamivir/therapeutic use , Point Mutation , Reverse Transcriptase Polymerase Chain Reaction , Zanamivir/pharmacology

ABSTRACT

Subject(s)

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