ABSTRACT
PIP: 6 male volunteers under well-controlled conditions were administered daily doses of lysine acetylsalicylate 3600 mg, flurbiprofen 100 mg and 1000 mg sulphasalazine every 12 hours over 3 sequential 4-day periods. There was a 15 day interval between treatments. Samples of ejaculates were obtained at 12 hours, 7 days, and 14 days after the last dose. Sperm physical parameters and prostaglandin (PG) levels were determined. Head alterations were observed with flurbiprofen and tail alterations plus spermatic aggregations persisting 2 weeks after treatment with sulphasalazine. The 19-hydroxy PGEs showed a significant decrease for the 3 drugs. Changes in the number, morphology, and motility of spermatozoa were not related to the PG levels, whereas antifertility actions of sulphasalazine were related to its sulphapyridine moiety.^ieng
Subject(s)
Contraception , Contraceptive Agents, Male , Genitalia , Germ Cells , Human Experimentation , Physiology , Spermatozoa , Urogenital System , Biology , Contraceptive Agents , Family Planning Services , ResearchABSTRACT
The effect of lysine salicylate, flurbiprofen and sulphasalazine on human seminal prostaglandin profiles of six normal individuals was studied. All of them were treated with pharmacological doses of the three agents for four days with rest periods of eighteen days in between. Sulphasalazine produced less prostaglandin (PG) inhibition relative to the other two antiinflammatory drugs but in contrast only sulphasalazine induced sperm changes. Infertility status associated with the ingestion of therapeutic levels of sulphasalaziane is not directly related to the endogenous PGEs and 19-OH PGEs, the major prostanoids in human semen. PG determinations were carried out using gas chromatographic (GC) techniques.
