High rates of anxiety detected in mothers of children with inconclusive cystic fibrosis screening results.

OBJECTIVE: The purpose was to assess postpartum depression, anxiety, and depression in mothers of children with an inconclusive diagnosis after a positive cystic fibrosis (CF) newborn screening (NBS), known as cystic fibrosis transmembrane conductance regulator (CFTR)-related metabolic syndrome (CRMS) or CF screen positive, inconclusive diagnosis (CFSPID). There is limited information on the prognosis and on the impact of this designation on maternal mental health. METHODS: Mothers of children with CRMS/CFSPID and CF identified by NBS were recruited from two centers in California. Maternal mental health was assessed using measures of depression, anxiety, and a scripted interview. Descriptive statistics and multivariate logistic regression were applied for data reporting. RESULTS: A total of 109 mothers were recruited: CF: 51, CRMS/CFSPID: 58. Mothers from both groups showed higher rates of depression and anxiety symptoms than women in the general population. CRMS/CFSPID and CF mothers had no significant difference on their self-reported symptoms of anxiety and depression after adjusting for potential confounders. Mothers equally reported that their child's diagnosis had a negative impact, and that genetic counseling had a positive impact on their emotional health. CONCLUSIONS: CF and CRMS/CFSPID diagnoses impact maternal mental health similarly. Uncertain prognosis of CRMS/CFSPID likely contributed to the negative mental health impact. Providers should consider conducting mental health screening for every mother of a child with CRMS/CFSPID, in addition to the recommended mental health screening for mothers of children with CF. Genetic counseling has potential to mitigate emotional stress on these families.

Interpretation problems with the BASC-3 SRP-A F Index for patients with depressive disorders: An initial analysis and proposal for future research.

The Behavioral Assessment System for Children, 3rd edition (BASC-3) is a commonly used clinical assessment to evaluate a variety of behavioral and emotional concerns in children and adolescents. The focus of the current study is on the problematic interpretation of the F Index of the BASC-3 self-report measure for adolescents (SRP-A) suffering from depressive disorders. In this study, we used data from 214 patients in an adolescent partial hospitalization program within a psychiatric facility, all of whom were administered the BASC-3 SRP-A upon intake. Results suggest that the BASC-3 SRP-A F Index may confound an invalid response style of intentional overreporting with significant psychopathology in this specific psychiatric population. Our findings raise the question of similar confounding across psychiatric diagnoses and similar interpretation problems. We encourage further studies with independent samples of adolescents with a broad spectrum of diagnoses to address this question and offer a proposal if indeed there is evidence of a more generalized problem with the SRP-A F Index. (PsycInfo Database Record (c) 2020 APA, all rights reserved).