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1.
Dent Med Probl ; 60(3): 421-426, 2023.
Article in English | MEDLINE | ID: mdl-37750735

ABSTRACT

BACKGROUND: The extrusion of apical debris is related to various factors, and may be affected by variations in technique or instrumentation system. Although the extrusion cannot be completely prevented, it is crucial to minimize the amount of extruded material. OBJECTIVES: The present study aimed to compare apical debris extrusion by the novel TruNatomy (TRN), OneCurve (OC) and ProTaper Next (PTN) instruments in curved root canals. MATERIAL AND METHODS: A total of 60 multi-rooted human mandibular molar teeth with moderate and severe curvature were selected and randomly divided into 3 groups. The root canals were prepared with the OC, TRN and PTN files. For collecting the debris extruded through the apical foramen, Eppendorf tubes were used. After the vaporizing period, the tubes were re-weighed, and the amount of the extruded debris was calculated by subtracting the initial weight from the final weight. Statistical analysis was performed with the Shapiro-Wilk and Kruskal-Wallis tests. The statistical significance level was set at p < 0.05. RESULTS: The least amount of debris was extruded with TRN and the greatest with PTN, but the difference between the groups was not significant (p = 0.257). CONCLUSIONS: All instrumentation systems were associated with debris extrusion. The tested file systems presented similar results in terms of apical debris extrusion in curved canals. The novel TRN system demonstrated promising results, comparable to OC and PTN.


Subject(s)
Root Canal Preparation , Tooth Apex , Humans , Tooth Apex/surgery , Molar/surgery
2.
Aust Endod J ; 48(2): 258-265, 2022 Aug.
Article in English | MEDLINE | ID: mdl-34259369

ABSTRACT

This study aimed to evaluate dentinal tubule penetration of the root canal filling material using various techniques such as cold lateral compaction, new generation thermoplastic core carrier and continuous-wave obturation. The root canals of premolar teeth were instrumented, and the teeth were allocated randomly to three groups (n = 15/group). After the obturation with three different techniques, three sections of 2-mm thickness at 2, 5 and 8-mm from the apex were examined under a confocal laser scanning microscope. The data were analysed of variance with a significance level of P < 0.05. There was no significant difference between techniques when parameters were evaluated in total (penetration depth P = 0.418, penetration area P = 0.701). The mean value of the cold lateral compaction group for maximum penetration depth was obtained higher than continuous wave (P = 0.004), whilst there was no significant difference between the thermoplastic core carrier and the other groups.


Subject(s)
Gutta-Percha , Root Canal Filling Materials , Dental Pulp Cavity , Epoxy Resins , Microscopy, Confocal , Root Canal Obturation/methods , Root Canal Preparation/methods , Syringes
3.
Ren Fail ; 37(8): 1273-9, 2015.
Article in English | MEDLINE | ID: mdl-26181645

ABSTRACT

AIM: To investigate the nature of dyslipidemia and its diversity in patients with systemic AA amyloidosis. METHODS: The reports of the kidney biopsies performed due to nephrotic proteinuria (>3.5 g/day/1.73 m(2)) with preserved renal function [glomerular filtration rate (GFR) >60 mL/min/1.73 m(2)] were reviewed. Clinical and laboratory data of the patients with systemic AA amyloidosis and primary glomerulonephritis (PG) were analyzed. RESULTS: A total of 104 (systemic AA amyloidosis: 43, PG: 61) patients were included in the study. Proteinuria and GFR levels were similar in both the groups. Patients with systemic AA amyloidosis group had lower serum albumin (p = 0.002), lower hemoglobin levels (p = 0.001), higher platelet counts (p = 0.002) and higher C-reactive protein levels (p = 0.001) compared to patients in PG group. Although the frequency of dyslipidemia was similar in the groups (86.0 vs. 93.4%), patients with systemic amyloidosis had both lower values of LDL-C (4.56 ± 2.05 vs. 5.49 ± 2.23 mmol/L, p = 0.028) and HDL-C (1.19 ± 0.36 vs. 1.35 ± 0.39 mmol/L, p = 0.035). Serum lipid levels were correlated with serum total protein, albumin and proteinuria levels in PG group. However, in the systemic amyloidosis group, only one clear correlation between serum lipid and hemoglobin levels was estimated. A multivariate analysis demonstrated that LDL-C was independently associated with the etiology of nephrotic proteinuria, serum total protein, serum albumin (inversely) and hemoglobin levels. CONCLUSIONS: Although dyslipidemia is closely associated with serum total protein, albumin and proteinuria in patients with PG, there is no clear such association in patients with systemic amyloidosis. Correlation between serum lipid and hemoglobin levels in this group and other findings point out that probably complex mechanisms take place in dyslipidemia of nephrotic syndrome caused by systemic AA amyloidosis.


Subject(s)
Amyloidosis/complications , Dyslipidemias/blood , Dyslipidemias/etiology , Glomerulonephritis/complications , Lipids/blood , Serum Albumin/analysis , Adult , Biopsy , Female , Glomerular Filtration Rate , Humans , Immunoglobulin Light-chain Amyloidosis , Kidney/pathology , Lipids/classification , Male , Middle Aged , Multivariate Analysis , Proteinuria/etiology , Retrospective Studies , Young Adult
4.
Rheumatol Int ; 33(4): 993-9, 2013 Apr.
Article in English | MEDLINE | ID: mdl-22847292

ABSTRACT

Secondary amyloidosis is the most frequent form of the systemic amyloidosis around the world. Data on frequency and nature of dyslipidemia in patients with secondary amyloidosis are not conclusive. We evaluated the lipid abnormalities and their association with clinical and laboratory characteristics of the patients with secondary amyloidosis. The reports of the kidney biopsies performed in our hospital were reviewed. Clinical and laboratory data of the patients with biopsy-proven secondary amyloidosis were analyzed retrospectively. A total of 102 patients were diagnosed as having secondary amyloidosis. Familial Mediterranean fever was the leading cause of secondary amyloidosis accounting for 42.2 % of the cases. The most frequent indication for kidney biopsy was the nephrotic range proteinuria. The most common clinical and laboratory characteristics at the time of the diagnosis were edema, proteinuria and impaired renal function. The frequency of the nephrotic range proteinuria and microscopic hematuria were 75.5 and 18.6 %, respectively. Dyslipidemia was found in 88 % of the cases. Serum lipids significantly correlated with estimated glomerular filtration rate (eGFR), but not with serum albumin or urine protein levels. We demonstrated that majority of the patients with secondary amyloidosis had serum lipid abnormalities. Dyslipidemia was closely associated with GFR in a manner that patients with advanced stage kidney disease had lower serum lipid levels.


Subject(s)
Amyloidosis/complications , Dyslipidemias/complications , Glomerular Filtration Rate/physiology , Kidney Diseases/complications , Kidney/physiopathology , Adolescent , Adult , Aged , Aged, 80 and over , Amyloidosis/pathology , Amyloidosis/physiopathology , Dyslipidemias/physiopathology , Familial Mediterranean Fever/complications , Familial Mediterranean Fever/pathology , Familial Mediterranean Fever/physiopathology , Female , Humans , Kidney/pathology , Kidney Diseases/physiopathology , Male , Middle Aged , Retrospective Studies
5.
Turk J Gastroenterol ; 16(3): 163-6, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16245230

ABSTRACT

Mitochondrial neurogastrointestinal encephalomyopathy is an autosomal recessive disease characterized by progressive ophthalmoplegia, peripheral neuropathy, mitochondrial abnormalities and gastrointestinal involvement. We describe a 19-year-old male having chronic intestinal pseudoobstruction associated with ophthalmoplegia and proximal muscle weakness. The clinical and radiologic features suggested the diagnosis of mitochondrial neurogastrointestinal encephalomyopathy. Mitochondrial genetic defects should be considered in the differential diagnosis of unexplained chronic gastrointestinal symptoms accompanied by neurological findings, especially in families where there is more than one individual with the same kind of symptoms.


Subject(s)
Duodenal Diseases/etiology , Gastritis, Hypertrophic/etiology , Intestinal Pseudo-Obstruction/etiology , Mitochondrial Encephalomyopathies/complications , Adult , Duodenal Diseases/physiopathology , Gastritis, Hypertrophic/physiopathology , Gastrointestinal Motility , Genetic Predisposition to Disease , Humans , Intestinal Pseudo-Obstruction/physiopathology , Male , Muscle Weakness/etiology , Ophthalmoplegia/etiology
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