ABSTRACT
Ergotism is an uncommon condition that affects patients with exposure to ergot alkaloids causing ischemia of extremities. We report the case of lower extremities ischemia caused by ergot toxicity in a human immunodeficiency virus (HIV) positive individual due to the interaction between ergot alkaloid and Cobicistat. In addition, we present a brief review of medical, and pharmacological aspects of this condition. To our knowledge, this is the second reported case describing this interaction.
Subject(s)
Adrenergic alpha-1 Receptor Agonists/adverse effects , Anti-HIV Agents/adverse effects , Cobicistat/adverse effects , Ergotamine/adverse effects , Ergotism/diagnosis , HIV Infections/drug therapy , Ischemia/chemically induced , Lower Extremity/blood supply , Drug Interactions , Ergotism/etiology , HIV Infections/complications , Humans , Male , Migraine Disorders/drug therapy , Young AdultABSTRACT
Testicular ischaemia after endovascular aortic aneurysm repair (EVAR) is a very uncommon complication. There are only a few cases reported in the literature and the pathogenesis remains unclear. We report a case of unilateral testicular ischaemia in the early postoperative period after EVAR.A 78-year-old man underwent standard EVAR without immediate complications. Twenty-four hours after the procedure, the patient developed sudden onset of right scrotal pain and a low-grade fever. Urgent testicular ultrasound showed ischaemic signs compromising 75% of the testicle. The patient was successfully managed with conservative treatment.Although the pathogenesis is unknown, acute thrombosis of the testicle feeding arteries is postulated as the main hypothesis in the physiopathogenesis.
