Doppler-stabilized fiber link with 6 dB noise improvement below the classical limit.

It is known that temperature variations and acoustic noise affect ultrastable frequency dissemination along optical fiber. Active stabilization techniques are adopted to compensate for the fiber-induced phase noise. However, despite this compensation, the ultimate link performances are limited by the delay-unsuppressed noise that is related to the propagation delay of the light in the fiber. We demonstrate a post-processing approach which enables us to overcome this limit. We implement a subtraction algorithm between the optical signal delivered at the remote link end and the round-trip signal. In this way, a 6 dB improvement beyond the delay-unsuppressed noise is obtained. We confirm the prediction with experimental data obtained on a 47 km metropolitan fiber link and propose how to extend this method for frequency dissemination.

Frequency transfer via a two-way optical phase comparison on a multiplexed fiber network.

We performed a two-way remote optical phase comparison on optical fiber. Two optical frequency signals were launched in opposite directions in an optical fiber and their phases were simultaneously measured at the other end. In this technique, the fiber noise is passively canceled, and we compared two optical frequencies at the ultimate 10(-21) stability level. The experiment was performed on a 47 km fiber that is part of the metropolitan network for Internet traffic. The technique relies on the synchronous measurement of the optical phases at the two ends of the link, which is here performed by digital electronics. This scheme offers some advantages with respect to active noise cancellation schemes, as the light travels only once in the fiber.

High-accuracy measurement of the blackbody radiation frequency shift of the ground-state hyperfine transition in 133Cs.

We report a high-accuracy direct measurement of the blackbody radiation shift of the 133Cs ground-state hyperfine transition. This frequency shift is one of the largest systematic frequency biases encountered in realizing the current definition of the International System of Units (SI) second. Uncertainty in the blackbody radiation frequency shift correction has led to its being the focus of intense theoretical effort by a variety of research groups. Our experimental measurement of the shift used three primary frequency standards operating at different temperatures. We achieved an uncertainty a factor of five smaller than the previous best direct measurement. These results tend to validate the claimed accuracy of the recently calculated values.

Large-area fiber-optic gyroscope on a multiplexed fiber network.

We describe a fiber-optic gyroscope based on the Sagnac effect, realized on a multiplexed telecom fiber network. Our loop encloses an area of 20 km² and coexists with Internet data traffic. This Sagnac interferometer is capable of detecting signals that are larger than 10(-8) (rad/s)/√Hz, thus approaching ring laser gyroscopes without using a narrow-linewidth laser or sophisticated optics. The proposed gyroscope could be useful for seismic applications, opening new possibilities for this kind of optical fiber sensor.

Virtues and problems of the high C-field Cs beam frequency standard.

The high C-field Cs beam frequency standard is presently a working machine that is undergoing first evaluations. The projected 10(-14 ) accuracy goal is as yet unattained, mainly because of inadequate C-field uniformity and stability. An analysis of the projected possible C-field improvements and the consequent uncertainty is here reported.

Role of K+ in GABA (gamma-aminobutyric acid)-evoked depolarization of peripheral nerve.

Isolated, desheathed sciatic nerves of the leopard frog or bull frog were used in studies to determine different sources/components of the depolarizing effect of GABA (gamma-aminobutyric acid) on myelinated fibers. During the depolarization induced by 1 mM GABA--which was reflected by an increase of 38.3% (S.E. +/- 2.2) in the amplitude of the evoked half-maximal A-fiber compound action potential--the level of extracellular potassium ([K+]o) measured at depths less than or equal to 200 microns in the nerve with ion-selective microelectrodes, increased by 0.096 mM (S.E. +/- 0.007). Changes in excitability preceded K+]o, and there was a significant difference between their peak latencies. Artificially raised levels of [K+]o, similar to those induced by GABA, caused extremely small changes (less than 10%) in the size of the evoked action potential. From the magnitude and time course of the GABA-evoked augmentation of levels of [K+]o, it can be concluded that potassium ions probably arise indirectly and play a secondary role in what appears to be a mainly receptor-mediated depolarization of axons. A much greater sensitivity to GABA was found for fibers of the dorsal roots in comparison with those of the ventral roots (maximal changes in excitability of 50% and 6% respectively). This suggests that the depolarization of ventral root fibers could be caused by [K+]o accumulation, and that there may be a preferentially localized distribution of receptors for GABA on the sensory axons of peripheral nerve.

Depolarizing action of GABA (gamma-aminobutyric acid) on myelinated fibers of peripheral nerves.

The inhibitory neurotransmitter GABA (gamma-aminobutyric acid) has been shown to have a depolarizing action on myelinated axons of both mammalian and amphibian peripheral nerves. In initial in vivo observations intravenous injections of GABA caused an increase in the excitability of the low-threshold, fast conducting fibers of the superficial radial and median nerves of the cat. Similar, graded, reversible effects were confirmed (using changes in the amplitude/integral of the stimulus-evoked A-fiber submaximal compound action potential to assess excitability) in in vitro studies with the isolated, desheathed frog sciatic nerve. GABA caused a mean maximal increase in half-maximal action potential of 29.8% (S.E. +/- 2.7), with an ED50 value of 0.09 mM and Hill coefficient of 0.70. This effect did not appear to desensitize, and could be reversibly antagonized by both bicuculline and picrotoxin. Comparison of agonist sensitivities showed a rank order of potency with muscimol greater than 3-aminopropanesulfonic acid greater than GABA greater than beta-guanidinopropionic acid greater than imidazole-acetic acid greater than guanidoacetic acid greater than delta-aminovaleric acid. With structure activity analysis the maximal activity was found to be related to N+-C separation near the 5 A value. Partial substitution of chloride ions in the superfusate by isethionate reversibly depressed the effect of GABA. These observations support the conclusion that extrasynaptic receptors for GABA are present on the myelinated axons of peripheral nerves.

Measuring of the quality of health care: a decision oriented typology.

Numerous methodologies have been devised to measure various aspects of the quality of health care. Revised bibliographies of articles of articles reporting these methodologies are made available periodically. This paper is an attempt to devise a use ful framework for cataloguing these methods in order that health care planners and administrators can readily assess the means available to quantify aspects of health care under their scrutiny. A decision tree is presented for the decision maker to follow through according to his requirements, and a discussion presents a brief summary of the methods in each particular category. Gaps indicating the need for further research are identified.