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1.
J Mass Spectrom ; 52(8): 550-556, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28608445

ABSTRACT

Amino acids are essential building blocks of life, and fluorinated derivatives have gained interest in chemistry and medicine. Modern mass spectrometry has enabled the study of oligo- and polypeptides as isolated entities in the gas phase, but predominantly as singly or even multiply charged species. While laser desorption of neutral peptides into adiabatically expanding supersonic noble gas jets is possible, UV-VIS spectroscopy, electric or magnetic deflectometry as well as quantum interferometry would profit from the possibility to prepare thermally slow molecular beams. This has typically been precluded by the fragility of the peptide bond and the fact that a peptide would rather 'fry', i.e. denature and fragment than 'fly'. Here, we explore how tailored perfluoroalkyl functionalization can reduce the intermolecular binding and thus increase the volatility of peptides and compare it to previously explored methylation, acylation and amidation of peptides. We show that this strategy is essential and enables the formation of thermal beams of intact neutral tripeptides, whereas only fragments were observed for an extensively fluoroalkyl-decorated nonapeptide. © 2017 The Authors. Journal of Mass Spectrometry Published by John Wiley & Sons Ltd.


Subject(s)
Oligopeptides/analysis , Oligopeptides/chemical synthesis , Amino Acid Sequence , Binding Sites , Fluorine , Isomerism , Mass Spectrometry , Protein Binding , Protein Conformation , Protein Stability , Volatilization
2.
Appl Phys B ; 122(6): 172, 2016.
Article in English | MEDLINE | ID: mdl-32355419

ABSTRACT

It has recently been shown that optical reflection gratings fabricated directly into an atom chip provide a simple and effective way to trap and cool substantial clouds of atoms (Nshii et al. in Nat Nanotechnol 8:321-324, 2013; McGilligan et al. in Opt Express 23(7):8948-8959, 2015). In this article, we describe how the gratings are designed and microfabricated and we characterise their optical properties, which determine their effectiveness as a cold atom source. We use simple scalar diffraction theory to understand how the morphology of the gratings determines the power in the diffracted beams.

4.
Nat Commun ; 6: 7336, 2015 Jun 11.
Article in English | MEDLINE | ID: mdl-26066053

ABSTRACT

Matter-wave interferometry can be used to probe the foundations of physics and to enable precise measurements of particle properties and fundamental constants. It relies on beam splitters that coherently divide the wave function. In atom interferometers, such elements are often realised using lasers by exploiting the dipole interaction or through photon absorption. It is intriguing to extend these ideas to complex molecules where the energy of an absorbed photon can rapidly be redistributed across many internal degrees of freedom. Here, we provide evidence that center-of-mass coherence can be maintained even when the internal energy and entropy of the interfering particle are substantially increased by absorption of photons from a standing light wave. Each photon correlates the molecular center-of-mass wave function with its internal temperature and splits it into a superposition with opposite momenta in addition to the beam-splitting action of the optical dipole potential.

5.
Phys Rev Lett ; 112(25): 250402, 2014 Jun 27.
Article in English | MEDLINE | ID: mdl-25014795

ABSTRACT

We measure the absolute absorption cross section of molecules using a matter-wave interferometer. A nanostructured density distribution is imprinted onto a dilute molecular beam through quantum interference. As the beam crosses the light field of a probe laser some molecules will absorb a single photon. These absorption events impart a momentum recoil which shifts the position of the molecule relative to the unperturbed beam. Averaging over the shifted and unshifted components within the beam leads to a reduction of the fringe visibility, enabling the absolute absorption cross section to be extracted with high accuracy. This technique is independent of the molecular density, it is minimally invasive and successfully eliminates many problems related to photon cycling, state mixing, photobleaching, photoinduced heating, fragmentation, and ionization. It can therefore be extended to a wide variety of neutral molecules, clusters, and nanoparticles.

6.
Nat Nanotechnol ; 8(5): 321-4, 2013 May.
Article in English | MEDLINE | ID: mdl-23563845

ABSTRACT

Laser-cooled atoms are central to modern precision measurements. They are also increasingly important as an enabling technology for experimental cavity quantum electrodynamics, quantum information processing and matter-wave interferometry. Although significant progress has been made in miniaturizing atomic metrological devices, these are limited in accuracy by their use of hot atomic ensembles and buffer gases. Advances have also been made in producing portable apparatus that benefits from the advantages of atoms in the microkelvin regime. However, simplifying atomic cooling and loading using microfabrication technology has proved difficult. In this Letter we address this problem, realizing an atom chip that enables the integration of laser cooling and trapping into a compact apparatus. Our source delivers ten thousand times more atoms than previous magneto-optical traps with microfabricated optics and, for the first time, can reach sub-Doppler temperatures. Moreover, the same chip design offers a simple way to form stable optical lattices. These features, combined with simplicity of fabrication and ease of operation, make these new traps a key advance in the development of cold-atom technology for high-accuracy, portable measurement devices.

7.
Phys Rev Lett ; 105(24): 243003, 2010 Dec 10.
Article in English | MEDLINE | ID: mdl-21231523

ABSTRACT

We investigate the use of a Bose-Einstein condensate trapped on an atom chip for making interferometric measurements of small energy differences. We measure and explain the noise in the energy difference of the split condensates, which derives from statistical noise in the number difference. We also consider systematic errors. A leading effect is the variation of the rf magnetic field in the trap with distance from the wires on the chip surface. This can produce energy differences that are comparable with those due to gravity.

8.
Opt Express ; 17(16): 14109-14, 2009 Aug 03.
Article in English | MEDLINE | ID: mdl-19654820

ABSTRACT

We have integrated magneto-optical traps (MOTs) into an atom chip by etching pyramids into a silicon wafer. These have been used to trap atoms on the chip, directly from a room temperature vapor of rubidium. This new atom trapping method provides a simple way to integrate several atom sources on the same chip. It represents a substantial advance in atom chip technology and offers new possibilities for atom chip applications such as integrated single atom or photon sources and molecules on a chip.


Subject(s)
Lab-On-A-Chip Devices , Magnetics/instrumentation , Optical Tweezers , Silicon/chemistry , Computer Simulation , Computer-Aided Design , Equipment Design , Equipment Failure Analysis , Light , Models, Theoretical , Scattering, Radiation , Systems Integration
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