Mast cell reaction in malignant laryngeal neoplasm.

INTRODUCTION: Mast cells are normal connective tissue residents. Their densities vary from an organ to other, but are constantly well represented in respiratory tract. Mast cell hyperplasia was found in many malignant tumors, but the significance of this phenomenon is still unknown. In the literature, there are few data about mast cell reaction in malignant laryngeal neoplasm. MATERIAL AND METHODS: We studied archive blocks from 127 laryngeal carcinomas. For histological diagnosis two sections were prepared for Hematoxylin-Eosin staining and Alcian blue-Safranin histochemistry at pH 0.2 for identifying mast cells. Examination has been performed with Nikon Eclipse 600 microscope. Microscopic images were analyzed with Lucia G program. Microvessel density was calculated using the hot spot method. RESULTS: Most of the cases were squamous cell carcinoma G1 - 24.4%, G2 - 56.69%, G3 - 18.11%, and 0.78% adenoid cystic carcinoma. Invasive squamous cell carcinoma mast cell microdensity was 2.19 and 4.66 in microinvasive squamous cell carcinoma. Mast cell microdensity in malignant laryngeal papillomatosis was 9.33 and 46.66 in adenoid cystic carcinoma. In carcinoma-associated mast cell hyperplasia, the large majority of mast cells were Alcian blue positive. CONCLUSIONS: In early stages, the mast cells are numerous (microinvasive squamous cell carcinoma mast cell microdensity 4.66) and rare or even absent in late stages (invasive squamous cell carcinoma mast cell microdensity 2.19). Mast cell microdensity in malignant laryngeal papillomatosis was 9.33 and 46.66 in cystic carcinoma. Alcianophil mast cells are present in tumor area, and safraninophil mast cells are residents of connective and muscular tissue, at a distance from the tumor.

[Arteriovenous malformation complicated by serious recurrent epistaxis]. / Malformatie arteriovenoasa complicata cu epistaxis grav recidivant.

Arteriovenous malformations in the region of the head and the neck are rarely manifested by epistaxis. These lesions are usually treated by the vascular surgeon, neurosurgeon, maxillofacial surgeon etc. Anyhow, the role of the specialist in otorhinolaryngology is indispensable when epistaxis gives morphological and functional modifications of the organs in the region of the head and neck. The paper reports on a particular case of severe, relapsing epistaxis, secondary to a geniomasseteric, right, invasive, cavernous hemangioma. The patient was admitted, for four times, in the period 1982-1984, into the O.R.L. clinic, Timisoara, and for two times into the clinic of maxillofacial surgery for severe, relapsing epistaxes in the right nasal pit. In 1983, the ligature of the external carotid artery and the partial ablation of the hemangioma were performed. In 1984, at a new right massive epistaxis, the nasal hemorrhage could not be arrested, and the patient died on November 10, 1984 due to a hemorrhagic shock.