Subject(s)
Cornea/pathology , Glaucoma/congenital , Color , Contact Lenses , Glaucoma/complications , Glaucoma/pathology , Humans , PhotographyABSTRACT
Tumor cells introduced into the rabbit vitreous produced a form of retinal neovascularization, but only when the tumor cells were in direct contact with the vascularized retina. This contrasted with the production of neovascularization at a distance of several millimeters in other angiogenesis models. An extract of adult rabbit vitreous was found to inhibit the growth of limbal neovascularization induced by tumors implanted in the rabbit corneal stroma. The experimental model of retrolental fibroplasia provides a bioassay to investigate further the apparent inhibitory substances in the vitreous.
Subject(s)
Retinal Vessels/physiopathology , Angiogenesis Inducing Agents/biosynthesis , Angiogenesis Inducing Agents/physiology , Animals , Cats , Dogs , Models, Biological , Neoplasm Transplantation , Neoplasms, Experimental , Oxygen , Rabbits , Retinopathy of Prematurity/metabolism , Retinopathy of Prematurity/physiopathology , Tissue Extracts/pharmacology , Transplantation, Homologous , Vitreous Body/surgeryABSTRACT
The demonstration of an inhibitory effect on the potent source of corneal neovascularization which is elicited by the stromal implantation of solid tumours raises the possibility that similar inhibition may be obtained in the animal model of retinal neovascularization. A major program has been initiated to extend the inhibitor studies observed in cornea to the retina.