ABSTRACT
Reported analgesic use following experimental surgery is low in rodents and there has been little published information on the frequency of analgesic use in other laboratory species. A structured literature review was conducted to examine analgesic administration in larger laboratory animals. The Scirus search engine was used to identify studies published in peer-reviewed journals that reported carrying out experimental surgery on 'large' laboratory animals, specifically rabbits, pigs, sheep, dogs and non-human primates. Seventy-four studies between 2000 and 2001 and 75 studies between 2005 and 2006 were included in the review. There was an increase in the reported administration of systemic analgesics to these species from 50% in 2000-2001 to 63% in 2005-2006. When all agents with analgesic properties were considered (systemic analgesics, local anaesthetics and anaesthetics with analgesic components), the proportion of papers that reported some form of analgesic administration to 'large' laboratory animals increased from 86% in 2000-2001 to 89% in 2005-2006. Overall rabbits, pigs, sheep, dogs and non-human primates were more likely to receive analgesics following potentially painful experimental procedures than has been reported in laboratory rodents but analgesic administration to 'large' laboratory species is still not optimal.
Subject(s)
Analgesia/veterinary , Analgesics , Animal Welfare , Animals, Laboratory/surgery , Pain, Postoperative/veterinary , Surgery, Veterinary/methods , Analgesia/statistics & numerical data , Animals , Dogs , Pain, Postoperative/prevention & control , Rabbits , Sheep , Species Specificity , SwineABSTRACT
A case of a massive, biopsy-proven, advanced seminoma in the mediastinum 12 years after orchidectomy for a malignant right-sided testicular tumour of unknown histology is presented. The highly unusual nature of this presentation is discussed and may represent either late relapse from skip-metastases or metachronous gonadal and extragonadal tumour development. Immunohistochemical staining was unable to distinguish the site of origin of the lesion.
Subject(s)
Mediastinal Neoplasms/diagnosis , Mediastinal Neoplasms/secondary , Orchiectomy , Seminoma/diagnosis , Seminoma/secondary , Adult , Humans , Male , Mediastinal Neoplasms/surgery , Neoplasms, Unknown Primary , Seminoma/surgery , Testicular Neoplasms/surgery , Time Factors , Tomography, X-Ray ComputedABSTRACT
Two patients who received vincristine therapy for lymphoma suffered marked impairment of ability to sing as a consequence of neurotoxicity. Slow recovery occurred on drug withdrawal.
Subject(s)
Antineoplastic Agents, Phytogenic/toxicity , Antineoplastic Agents, Phytogenic/therapeutic use , Laryngeal Nerves/drug effects , Lymphoma/drug therapy , Vincristine/toxicity , Vincristine/therapeutic use , Voice Disorders/chemically induced , Aged , Humans , Male , Vocal Cord Paralysis/chemically inducedABSTRACT
A retrospective study of 109 patients with dermatitis herpetiformis showed that malignant tumours had developed in seven patients, the expected incidence being 2.93, giving a relative risk of 2.38. In three of the seven patients the malignancy was a lymphoma, giving a relative risk of 100 for this tumour (expected incidence 0.03). In six of the seven patients who developed malignancies small-intestinal biopsy specimens were macroscopically abnormal, giving a relative risk of 4.22 in this group, which is similar to that reported in adult coeliac disease. Patients treated with a gluten-free diet appeared to have a reduced risk of developing malignancy compared with those taking a normal diet (relative risk with gluten-free diet 1.01 and with normal diet 3.09). A small subgroup of eight patients with linear IgA dermatitis herpetiformis were also studied: three developed malignant disease and in one the tumour was a lymphoma.