Inspirational Adversarial Image Generation.

The task of image generation started receiving some attention from artists and designers, providing inspiration for new creations. However, exploiting the results of deep generative models such as Generative Adversarial Networks can be long and tedious given the lack of existing tools. In this work, we propose a simple strategy to inspire creators with new generations learned from a dataset of their choice, while providing some control over the output. We design a simple optimization method to find the optimal latent parameters corresponding to the closest generation to any input inspirational image. Specifically, we allow the generation given an inspirational image of the user's choosing by performing several optimization steps to recover optimal parameters from the model's latent space. We tested several exploration methods from classical gradient descents to gradient-free optimizers. Many gradient-free optimizers just need comparisons (better/worse than another image), so they can even be used without numerical criterion nor inspirational image, only with human preferences. Thus, by iterating on one's preferences we can make robust facial composite or fashion generation algorithms. Our results on four datasets of faces, fashion images, and textures show that satisfactory images are effectively retrieved in most cases.

BRANE Clust: Cluster-Assisted Gene Regulatory Network Inference Refinement.

Discovering meaningful gene interactions is crucial for the identification of novel regulatory processes in cells. Building accurately the related graphs remains challenging due to the large number of possible solutions from available data. Nonetheless, enforcing a priori on the graph structure, such as modularity, may reduce network indeterminacy issues. BRANE Clust (Biologically-Related A priori Network Enhancement with Clustering) refines gene regulatory network (GRN) inference thanks to cluster information. It works as a post-processing tool for inference methods (i.e., CLR, GENIE3). In BRANE Clust, the clustering is based on the inversion of a system of linear equations involving a graph-Laplacian matrix promoting a modular structure. Our approach is validated on DREAM4 and DREAM5 datasets with objective measures, showing significant comparative improvements. We provide additional insights on the discovery of novel regulatory or co-expressed links in the inferred Escherichia coli network evaluated using the STRING database. The comparative pertinence of clustering is discussed computationally (SIMoNe, WGCNA, X-means) and biologically (RegulonDB). BRANE Clust software is available at: http://www-syscom.univ-mlv.fr/~pirayre/Codes-GRN-BRANE-clust.html.

BARCHAN: Blob Alignment for Robust CHromatographic ANalysis.

Two-dimensional gas chromatography (GC×GC) plays a central role into the elucidation of complex samples. The automation of the identification of peak areas is of prime interest to obtain a fast and repeatable analysis of chromatograms. To determine the concentration of compounds or pseudo-compounds, templates of blobs are defined and superimposed on a reference chromatogram. The templates then need to be modified when different chromatograms are recorded. In this study, we present a chromatogram and template alignment method based on peak registration called BARCHAN. Peaks are identified using a robust mathematical morphology tool. The alignment is performed by a probabilistic estimation of a rigid transformation along the first dimension, and a non-rigid transformation in the second dimension, taking into account noise, outliers and missing peaks in a fully automated way. Resulting aligned chromatograms and masks are presented on two datasets. The proposed algorithm proves to be fast and reliable. It significantly reduces the time to results for GC×GC analysis.

BRANE Cut: biologically-related a priori network enhancement with graph cuts for gene regulatory network inference.

BACKGROUND: Inferring gene networks from high-throughput data constitutes an important step in the discovery of relevant regulatory relationships in organism cells. Despite the large number of available Gene Regulatory Network inference methods, the problem remains challenging: the underdetermination in the space of possible solutions requires additional constraints that incorporate a priori information on gene interactions. METHODS: Weighting all possible pairwise gene relationships by a probability of edge presence, we formulate the regulatory network inference as a discrete variational problem on graphs. We enforce biologically plausible coupling between groups and types of genes by minimizing an edge labeling functional coding for a priori structures. The optimization is carried out with Graph cuts, an approach popular in image processing and computer vision. We compare the inferred regulatory networks to results achieved by the mutual-information-based Context Likelihood of Relatedness (CLR) method and by the state-of-the-art GENIE3, winner of the DREAM4 multifactorial challenge. RESULTS: Our BRANE Cut approach infers more accurately the five DREAM4 in silico networks (with improvements from 6% to 11%). On a real Escherichia coli compendium, an improvement of 11.8% compared to CLR and 3% compared to GENIE3 is obtained in terms of Area Under Precision-Recall curve. Up to 48 additional verified interactions are obtained over GENIE3 for a given precision. On this dataset involving 4345 genes, our method achieves a performance similar to that of GENIE3, while being more than seven times faster. The BRANE Cut code is available at: http://www-syscom.univ-mlv.fr/~pirayre/Codes-GRN-BRANE-cut.html. CONCLUSIONS: BRANE Cut is a weighted graph thresholding method. Using biologically sound penalties and data-driven parameters, it improves three state-of-the art GRN inference methods. It is applicable as a generic network inference post-processing, due to its computational efficiency.

Learning hierarchical features for scene labeling.

Scene labeling consists of labeling each pixel in an image with the category of the object it belongs to. We propose a method that uses a multiscale convolutional network trained from raw pixels to extract dense feature vectors that encode regions of multiple sizes centered on each pixel. The method alleviates the need for engineered features, and produces a powerful representation that captures texture, shape, and contextual information. We report results using multiple postprocessing methods to produce the final labeling. Among those, we propose a technique to automatically retrieve, from a pool of segmentation components, an optimal set of components that best explain the scene; these components are arbitrary, for example, they can be taken from a segmentation tree or from any family of oversegmentations. The system yields record accuracies on the SIFT Flow dataset (33 classes) and the Barcelona dataset (170 classes) and near-record accuracy on Stanford background dataset (eight classes), while being an order of magnitude faster than competing approaches, producing a $(320\times 240)$ image labeling in less than a second, including feature extraction.

Power Watershed: A Unifying Graph-Based Optimization Framework.

In this work, we extend a common framework for graph-based image segmentation that includes the graph cuts, random walker, and shortest path optimization algorithms. Viewing an image as a weighted graph, these algorithms can be expressed by means of a common energy function with differing choices of a parameter q acting as an exponent on the differences between neighboring nodes. Introducing a new parameter p that fixes a power for the edge weights allows us to also include the optimal spanning forest algorithm for watershed in this same framework. We then propose a new family of segmentation algorithms that fixes p to produce an optimal spanning forest but varies the power q beyond the usual watershed algorithm, which we term the power watershed. In particular, when q=2, the power watershed leads to a multilabel, scale and contrast invariant, unique global optimum obtained in practice in quasi-linear time. Placing the watershed algorithm in this energy minimization framework also opens new possibilities for using unary terms in traditional watershed segmentation and using watershed to optimize more general models of use in applications beyond image segmentation.