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Bioorg Med Chem Lett
; 20(10): 3116-9, 2010 May 15.
Article
in English
| MEDLINE
| ID: mdl-20417098
ABSTRACT
Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. The synthesis, SAR and biological profiles of the series are described.