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Int J Infect Dis ; 69: 50-54, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29408476

ABSTRACT

A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen on 18F-fluorodeoxyglucose positron emission tomography/computed tomography. The diagnosis of GCA was retained, and treatment with prednisolone was started. Given the aneurysm of the abdominal aorta, the patient underwent replacement of the abdominal aorta with an allograft. Histology showed intense chronic arteritis attributed to atherosclerosis with dissection. However, Coxiella burnetii infection was confirmed by serology and then by culture and molecular biology on the surgical specimen. A combination of hydroxychloroquine and doxycycline was added to tapered prednisolone and the outcome was favourable.


Subject(s)
Aorta, Abdominal/microbiology , Aortitis/microbiology , Coxiella burnetii/isolation & purification , Giant Cell Arteritis/diagnosis , Positron Emission Tomography Computed Tomography , Q Fever/therapy , Aged , Anti-Bacterial Agents/therapeutic use , Aorta, Abdominal/diagnostic imaging , Aortitis/therapy , Doxycycline/therapeutic use , Fluorodeoxyglucose F18 , Giant Cell Arteritis/therapy , Heart Valve Prosthesis Implantation , Humans , Hydroxychloroquine/therapeutic use , Male , Q Fever/complications , Q Fever/diagnostic imaging , Treatment Outcome
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