Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Magnes Res ; 28(4): 126-35, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26878252

ABSTRACT

Magnesium-deficient patients show dysfunctional calcium (Ca(2+)) metabolism due to defective parathyroid hormone (PTH) secretion. In mice and rats, long-term magnesium (Mg(2+)) deprivation causes hyperphosphaturia and increases fibroblast growth factor 23 (FGF23) secretion, despite normal serum phosphate (Pi) and Ca(2+). Electrolyte disturbances during early hypomagnesemia may explain the response of mice to long-term Mg(2+) deprivation, but our knowledge of electrolyte homeostasis during this stage is limited. This study compares the effect of both short- and long-term Mg(2+) restriction on the electrolyte balance in mice. Mice were fed control or Mg(2+)-deficient diets for one to three days, one week, or three weeks. Prior to killing the mice, urine was collected over 24 h using metabolic cages. Within 24 h of Mg(2+) deprivation, hypomagnesemia, hypocalcemia and hyperphosphatemia developed, and after three days of Mg(2+) deprivation, serum potassium (K(+)) was increased. These changes were accompanied by a reduction in urinary volume, hyperphosphaturia, hypocalciuria and decreased Mg(2+), sodium (Na(+)) and K(+) excretion. Surprisingly, after one week of Mg(2+) deprivation, serum K(+), Pi and Ca(2+) had normalized, showing that mineral homeostasis is most affected during early hypomagnesemia. Serum Pi and K(+) are known to stimulate secretion of FGF23 and aldosterone, which are usually elevated during Mg(2+) deficiency. Thus, the hyperphosphatemia and increased serum K(+) concentration observed during short-term Mg(2+) deprivation may help our understanding of adaptation to chronic Mg(2+) deficiency.


Subject(s)
Calcium/blood , Hyperkalemia/etiology , Hyperphosphatemia/etiology , Hypocalcemia/etiology , Magnesium Deficiency/complications , Magnesium/blood , Phosphates/blood , Potassium/blood , Adaptation, Physiological , Animals , Biomarkers/blood , Biomarkers/urine , Body Weight , Calcium/urine , Disease Models, Animal , Fibroblast Growth Factor-23 , Hyperkalemia/blood , Hyperkalemia/physiopathology , Hyperkalemia/urine , Hyperphosphatemia/blood , Hyperphosphatemia/physiopathology , Hyperphosphatemia/urine , Hypocalcemia/blood , Hypocalcemia/physiopathology , Hypocalcemia/urine , Magnesium/urine , Magnesium Deficiency/blood , Magnesium Deficiency/physiopathology , Magnesium Deficiency/urine , Male , Mice, Inbred C57BL , Phosphates/urine , Potassium/urine , Time Factors , Water-Electrolyte Balance
SELECTION OF CITATIONS
SEARCH DETAIL
...