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1.
Sports Med ; 51(3): 581-592, 2021 Mar.
Article in English | MEDLINE | ID: mdl-33332011

ABSTRACT

AIM: The aim of this study was to examine the associations between the injury risk and the acute (AL) to chronic (CL) workload ratio (ACWR) by substituting the original CL with contrived values to assess the role of CL (i.e., the presence and implications of statistical artefacts). METHODS: Using previously published data, we generated a contrived ACWR by dividing the AL by fixed and randomly generated CLs, and we compared these results to real data. We also reproduced previously reported subgroup analyses, including dichotomising players' data above and below the median CL. Our analyses follow the same, previously published modelling approach. RESULTS: The analyses with original data showed effects compatible with higher injury risk for ACWR only (odd ratios, OR: 2.45, 95% CI 1.28-4.71). However, we observed similar effects by dividing AL by the "contrived" fixed and randomly generated CLs: OR 1.95 (1.18-3.52) dividing by 1510 (average CL); and OR ranging from 1.16 to 2.07, using random CL 1.53 (mean). Random ACWRs reduced the variance relative to the original AL and further inflated the ORs (mean OR 1.89, from 1.42 to 2.70). ACWR causes artificial reclassification of players compared to AL alone. Finally, neither ACWR nor AL alone confer a meaningful predictive advantage to an intercept-only model, even within the training sample (c-statistic 0.574/0.544 vs. 0.5 in both ACWR/AL and intercept-only models, respectively). DISCUSSION: ACWR is a rescaling of the explanatory variable (AL, numerator), in turn magnifying its effect estimates and decreasing its variance despite conferring no predictive advantage. Other ratio-related transformations (e.g., reducing the variance of the explanatory variable and unjustified reclassifications) further inflate the OR of AL alone with injury risk. These results also disprove the etiological theory behind this ratio and its components. We suggest ACWR be dismissed as a framework and model, and in line with this, injury frameworks, recommendations, and consensus be updated to reflect the lack of predictive value of and statistical artefacts inherent in ACWR models.


Subject(s)
Athletic Injuries , Workload , Humans , Risk Factors
2.
Sports Med ; 50(9): 1667-1681, 2020 Sep.
Article in English | MEDLINE | ID: mdl-32676903

ABSTRACT

PURPOSE: To define based on expert opinion and practical experience using a systematic and scientific approach, (1) the perceived most effective exercise-based strategies to prevent muscle injury in elite footballers; and, (2) when and how these exercise programs are prescribed based on the number of days between games i.e. implementation strategy. METHODS: A Delphi survey obtained opinions and assessed for agreement. Delphi respondents consisted of 21 experienced sports practitioners (12 ± 5.3 years in elite football and with an academic background) belonging to 18 teams from the Big-5 European football leagues; England, France, Germany, Italy, Spain. Three teams were represented collaboratively by two experts. The Delphi process involves sequential rounds each evolving based on the responses from the previous. The number of rounds is not pre-defined and continues until an agreement is either achieved or it is clear that no agreement will be reached. Frequency of responses was recorded where the agreement was sought (i.e. in closed questions) and an agreement was achieved if ≥ 13/18 (70%) respondents agreed. For open-ended questions, a qualitative content analysis was performed to identify recurring themes and when themes were specified by ≥ 13 (70%), these were also considered as reaching an agreement. Practitioners had the opportunity to raise concerns if they disagreed with the 'agreement from recurrent themes'. RESULTS: There were four Delphi rounds (100% response for each round). Sprinting and High-Speed Running (HSR) focused exercises were agreed as most effective (perceived) to prevent muscle injuries. Eccentric exercise was perceived as the next most effective. It was agreed that sprinting and HSR be integrated into coaches training, and target 100% of players worst-case match scenario (e.g. volume, intensity) based on individual maximum speeds. Eccentric exercise was recommended to be implemented according to the context of the main football session and planned/actual sprinting and HSR content. It was agreed that eccentrics can be performed before or after training, context dependent. The day to perform specific sprinting and HSR or eccentric exercises depended on the proximity of previous and upcoming matches. Other exercises reaching agreement as 'somewhat effective' included concentric and isometric, horizontal and vertical plyometrics, coordination, core and dynamic flexibility in addition to core stability. No agreement was reached for multi-joint, resisted sprinting, kicking or agility exercises nor simultaneous single-leg strength and stability. Finally, no agreement was reached regarding programming variables e.g. sets, repetitions as deemed too contextual. CONCLUSION: Regarding exercise-based strategies, particular importance agreed by the Delphi expert group was to focus on sprinting, HSR and eccentric exercises, integrated with a variety of other exercise modes which also carry some level of effectiveness in a multidimensional programme. Context was agreed to be key and decision-making about when to undertake/ how to prescribe exercise strategies to be made according to the content of normal football training and the proximity of matches.


Subject(s)
Athletic Injuries/prevention & control , Muscle, Skeletal/injuries , Physical Conditioning, Human/methods , Soccer/injuries , Athletes , Europe , Humans , Male , Surveys and Questionnaires
4.
J Sports Sci ; 37(22): 2522-2529, 2019 Nov.
Article in English | MEDLINE | ID: mdl-31409199

ABSTRACT

The aim of the present study was to determine the factors affecting sports involvement in a school-based adolescent population. The cross-sectional cohort study assessed anthropometry, physical capacities and motor competence in 501 boys (aged 10-16 y), from junior (10-12 y) and senior (13-16 y) cohorts. Sports participation data was collected from junior participants. Multivariate analysis of covariance revealed moderate maturity, anthropometry, physical capacity and motor competence differences between sports in the senior cohort (F = 2.616, p < 0.001, η2 = .08), but not in the junior cohort. Furthermore, differences in physical fitness were revealed between playing levels (F = 2.616, p < 0.001, η2 = .08), with a discriminant analysis correctly classifying 73% of participants using aerobic fitness and vertical jump measures. Representative level participants engaged in more structured training and commenced organised competition at a later age (F = 4.332, p < 0.001, η2 = .21). This study's findings are twofold: 1) physical and motor competence profiles differ more between sports with increasing age, and 2) participants at a higher level of competition report delayed engagement in their main sport. As a result, schools may be the ideal environment in which to provide children and adolescents with the opportunity to sample different sports.


Subject(s)
Anthropometry , Aptitude/physiology , Motor Skills/physiology , Physical Fitness , Youth Sports/physiology , Adolescent , Age Factors , Australia , Child , Competitive Behavior/physiology , Cross-Sectional Studies , Humans , Male , Schools , Sexual Maturation/physiology
5.
Acta Neurochir (Wien) ; 159(3): 485-490, 2017 03.
Article in English | MEDLINE | ID: mdl-28108854

ABSTRACT

BACKGROUND: Intracranial pressure monitoring is commonly undertaken to assess and manage acute patients following head injury. However, ICP monitoring can also be a useful diagnostic tool in the management of CSF dynamics in elective patients. To date, there is little published research to suggest how long these elective patients require ICP monitoring in order to gain an accurate picture of a patient's ICP dynamics. At the author's institution, a minimum of 48-h data collection is currently undertaken in patients with a suspected ICP abnormality. METHODS: A retrospective audit was undertaken comparing overall median ICP and overall median pulse amplitude data at three time points, 24 h, 48 h and total time analysed (if longer than 48 h). Paired T-test was used to assess if there were statistically significant differences between 24-h versus 48-h monitoring and total duration of monitoring. All patients admitted over a 6-month period for ICPM who met the inclusion/exclusion criteria were included. RESULTS: Eighteen patients met the criteria. Median age was 45.8 years, range 22-83 years, 12 female and 6 male. No complications were experienced as a result of ICPM. Diagnosis included NPH, IIH, suspected shunt malfunction and Chiari malformation. The results demonstrated that there is no statistical difference between 24 h and 48 h or longer for both overall median ICP and pulse amplitude. CONCLUSION: The results of this study demonstrate that ICP monitoring of elective adult patients using a Spiegelberg intraparenchymal bolt for 24 h gives an accurate picture of a patient's ICP dynamics compared with longer periods of monitoring.


Subject(s)
Intracranial Pressure/physiology , Monitoring, Physiologic/standards , Adult , Aged , Aged, 80 and over , Arnold-Chiari Malformation/diagnosis , Female , Humans , Hydrocephalus, Normal Pressure/diagnosis , Male , Middle Aged , Pseudotumor Cerebri/diagnosis , Retrospective Studies , Time Factors , Young Adult
6.
Scand J Med Sci Sports ; 27(1): 55-65, 2017 Jan.
Article in English | MEDLINE | ID: mdl-26677824

ABSTRACT

To determine if pre-cooling (PC) following heat-acclimatization (HA) can further improve self-paced endurance performance in the heat, 13 male triathletes performed two 20-km cycling time-trials (TT) at 35 °C, 50% relative humidity, before and after an 8-day training camp, each time with (PC) or without (control) ice vest PC. Pacing strategies, physiological and perceptual responses were assessed during each TT. PC and HA induced moderate (+10 ± 18 W; effect size [ES] 4.4 ± 4.6%) and very large (+28 ± 19 W; ES 11.7 ± 4.1%) increases in power output (PO), respectively. The overall PC effect became unclear after HA (+4 ± 14 W; ES 1.4 ± 3.0%). However, pacing analysis revealed that PC remained transiently beneficial post-HA, i.e., during the first half of the TT. Both HA and PC pre-HA were characterized by an enhanced PO without increased cardio-thermoregulatory or perceptual disturbances, while post-HA PC only improved thermal comfort. PC improved 20-km TT performance in unacclimatized athletes, but an 8-day HA period attenuated the magnitude of this effect. The respective converging physiological responses to HA and PC may explain the blunting of PC effectiveness. However, perceptual benefits from PC can still account for the small alterations to pacing noted post-HA.


Subject(s)
Acclimatization/physiology , Athletic Performance/physiology , Bicycling/physiology , Cryotherapy/methods , Hot Temperature , Physical Endurance/physiology , Adult , Body Temperature Regulation , Cross-Over Studies , Humans , Ice , Male , Random Allocation , Skin Temperature
7.
Br J Sports Med ; 49(18): 1164-73, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26069301

ABSTRACT

Exercising in the heat induces thermoregulatory and other physiological strain that can lead to impairments in endurance exercise capacity. The purpose of this consensus statement is to provide up-to-date recommendations to optimise performance during sporting activities undertaken in hot ambient conditions. The most important intervention one can adopt to reduce physiological strain and optimise performance is to heat acclimatise. Heat acclimatisation should comprise repeated exercise-heat exposures over 1-2 weeks. In addition, athletes should initiate competition and training in a euhydrated state and minimise dehydration during exercise. Following the development of commercial cooling systems (eg, cooling-vest), athletes can implement cooling strategies to facilitate heat loss or increase heat storage capacity before training or competing in the heat. Moreover, event organisers should plan for large shaded areas, along with cooling and rehydration facilities, and schedule events in accordance with minimising the health risks of athletes, especially in mass participation events and during the first hot days of the year. Following the recent examples of the 2008 Olympics and the 2014 FIFA World Cup, sport governing bodies should consider allowing additional (or longer) recovery periods between and during events, for hydration and body cooling opportunities, when competitions are held in the heat.


Subject(s)
Exercise/physiology , Hot Temperature , Sports/physiology , Acclimatization/physiology , Athletic Performance/physiology , Beverages , Body Temperature Regulation/physiology , Clothing , Cold Temperature , Cool-Down Exercise/physiology , Dehydration/prevention & control , Fluid Therapy/methods , Heat Stress Disorders/physiopathology , Heat Stress Disorders/prevention & control , Humans , Sports Medicine/methods
8.
Scand J Med Sci Sports ; 25 Suppl 1: 6-19, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25943653

ABSTRACT

Exercising in the heat induces thermoregulatory and other physiological strain that can lead to impairments in endurance exercise capacity. The purpose of this consensus statement is to provide up-to-date recommendations to optimize performance during sporting activities undertaken in hot ambient conditions. The most important intervention one can adopt to reduce physiological strain and optimize performance is to heat acclimatize. Heat acclimatization should comprise repeated exercise-heat exposures over 1-2 weeks. In addition, athletes should initiate competition and training in a euhydrated state and minimize dehydration during exercise. Following the development of commercial cooling systems (e.g., cooling vest), athletes can implement cooling strategies to facilitate heat loss or increase heat storage capacity before training or competing in the heat. Moreover, event organizers should plan for large shaded areas, along with cooling and rehydration facilities, and schedule events in accordance with minimizing the health risks of athletes, especially in mass participation events and during the first hot days of the year. Following the recent examples of the 2008 Olympics and the 2014 FIFA World Cup, sport governing bodies should consider allowing additional (or longer) recovery periods between and during events for hydration and body cooling opportunities when competitions are held in the heat.


Subject(s)
Acclimatization/physiology , Drinking Behavior/physiology , Exercise/physiology , Heat Stress Disorders/prevention & control , Hot Temperature/adverse effects , Sports/physiology , Athletic Performance/physiology , Body Temperature Regulation/physiology , Dehydration/complications , Dehydration/prevention & control , Dehydration/therapy , Fluid Therapy , Heat Stress Disorders/etiology , Heat Stress Disorders/therapy , Humans
9.
Scand J Med Sci Sports ; 25 Suppl 1: 287-95, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25943680

ABSTRACT

This study examined the association between monitoring tools, training loads, and performance in concurrent heat and hypoxia (H + H) compared with temperate training environments. A randomized parallel matched-group design involved 18 well-trained male cyclists. Participants performed 12 interval sessions (3 weeks) in either H + H (32 ± 1 °C, 50% RH, 16.6% O2 normobaric hypoxia) or control (21 °C, 50% RH, 21% O2 ), followed by a seven-session taper (3 weeks; 21 °C, 50% RH, 21% O2 ), while also maintaining external training (∼ 6-10 h/week). A 20-km time trial (TT) was completed pre- and post-training block (21 °C, 50% RH, 21% O2 ). Before each TT and once weekly, a 4-min cycle warm-up (70% 4-min mean maximum power) was completed. Visual analog scale rating for pain, recovery, and fatigue was recorded before the warm-up, with heart rate (HREx ), heart rate recovery (HRR), and rating of perceived exertion (RPEWU ) recorded following. Training load was quantified using the session rating of perceived exertion (sRPE) method throughout. Overall TT improved 35 ± 47 s with moderate correlations to HRR (r = 0.49) and recovery (r = -0.55). H + H group had a likely greater reduction in HREx [ES = -0.50 (90% CL) (-0.88; 0.12)] throughout and a greater sRPE (ES = 1.20 [0.41; 1.99]), and reduction in HRR [ES = -0.37 (-0.70;-0.04)] through the overload. RPEWU was associated with weekly training load (r = 0.37). These findings suggest that recovery and HRR in a temperate environment may be used as simple measures to identify an athlete's readiness to perform. Alternatively, the relationship of RPEWU and training load suggests that perception of effort following a standardized warm-up may be a valid measure when monitoring an athlete's training response, irrespective of the training environment.


Subject(s)
Bicycling/physiology , Fatigue/physiopathology , Heart Rate/physiology , Hot Temperature/adverse effects , Hypoxia/physiopathology , Physical Exertion/physiology , Physical Fitness/physiology , Adult , Exercise Test , Fatigue/etiology , Humans , Male , Monitoring, Physiologic/methods , Single-Blind Method
10.
Int J Sports Med ; 36(1): 49-53, 2015 Jan.
Article in English | MEDLINE | ID: mdl-25254901

ABSTRACT

We compared the accuracy of 2 GPS systems with different sampling rates for the determination of distances covered at high-speed and metabolic power derived from a combination of running speed and acceleration. 8 participants performed 56 bouts of shuttle intermittent running wearing 2 portable GPS devices (SPI-Pro, GPS-5 Hz and MinimaxX, GPS-10 Hz). The GPS systems were compared with a radar system as a criterion measure. The variables investigated were: total distance (TD), high-speed distance (HSR>4.17 m·s(-1)), very high-speed distance (VHSR>5.56 m·s(-1)), mean power (Pmean), high metabolic power (HMP>20 W·kg(-1)) and very high metabolic power (VHMP>25 W·kg(-1)). GPS-5 Hz had low error for TD (2.8%) and Pmean (4.5%), while the errors for the other variables ranged from moderate to high (7.5-23.2%). GPS-10 Hz demonstrated a low error for TD (1.9%), HSR (4.7%), Pmean (2.4%) and HMP (4.5%), whereas the errors for VHSR (10.5%) and VHMP (6.2%) were moderate. In general, GPS accuracy increased with a higher sampling rate, but decreased with increasing speed of movement. Both systems could be used for calculating TD and Pmean, but they cannot be used interchangeably. Only GPS-10 Hz demonstrated a sufficient level of accuracy for quantifying distance covered at higher speeds or time spent at very high power.


Subject(s)
Geographic Information Systems , Running/physiology , Soccer/physiology , Time and Motion Studies , Acceleration , Adolescent , Energy Metabolism , Humans , Male , Reproducibility of Results
11.
Cell Death Differ ; 22(1): 156-63, 2015 Jan.
Article in English | MEDLINE | ID: mdl-25168243

ABSTRACT

Metabolic reprogramming is a hallmark of cancer cells. Strap (stress-responsive activator of p300) is a novel TPR motif OB-fold protein that contributes to p53 transcriptional activation. We show here that, in addition to its established transcriptional role, Strap is localised at mitochondria where one of its key interaction partners is ATP synthase. Significantly, the interaction between Strap and ATP synthase downregulates mitochondrial ATP production. Under glucose-limiting conditions, cancer cells are sensitised by mitochondrial Strap to apoptosis, which is rescued by supplementing cells with an extracellular source of ATP. Furthermore, Strap augments the apoptotic effects of mitochondrial p53. These findings define Strap as a dual regulator of cellular reprogramming: first as a nuclear transcription cofactor and second in the direct regulation of mitochondrial respiration.


Subject(s)
Mitochondria/metabolism , Neoplasm Proteins/metabolism , Oxidative Phosphorylation , Oxygen Consumption/physiology , Tumor Suppressor Protein p53/metabolism , Apoptosis/physiology , Glucose/genetics , Glucose/metabolism , HeLa Cells , Humans , Mitochondrial Proton-Translocating ATPases , Neoplasm Proteins/genetics , RNA-Binding Proteins , Transcriptional Activation/physiology , Tumor Suppressor Protein p53/genetics
12.
Br J Sports Med ; 47 Suppl 1: i59-69, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24282209

ABSTRACT

OBJECTIVES: To examine with a parallel group study design the performance and physiological responses to a 14-day off-season 'live high-train low in the heat' training camp in elite football players. METHODS: Seventeen professional Australian Rules Football players participated in outdoor football-specific skills (32 ± 1°C, 11.5 h) and indoor strength (23 ± 1°C, 9.3 h) sessions and slept (12 nights) and cycled indoors (4.3 h) in either normal air (NORM, n=8) or normobaric hypoxia (14 ± 1 h/day, FiO2 15.2-14.3%, corresponding to a simulated altitude of 2500-3000 m, hypoxic (HYP), n=9). They completed the Yo-Yo Intermittent Recovery level 2 (Yo-YoIR2) in temperate conditions (23 ± 1°C, normal air) precamp (Pre) and postcamp (Post). Plasma volume (PV) and haemoglobin mass (Hb(mass)) were measured at similar times and 4 weeks postcamp (4WPost). Sweat sodium concentration ((Na(+))(sweat)) was measured Pre and Post during a heat-response test (44°C). RESULTS: Both groups showed very large improvements in Yo-YoIR2 at Post (+44%; 90% CL 38, 50), with no between-group differences in the changes (-1%; -9, 9). Postcamp, large changes in PV (+5.6%; -1.8, 5.6) and (Na(+))sweat (-29%; -37, -19) were observed in both groups, while Hb(mass) only moderately increased in HYP (+2.6%; 0.5, 4.5). At 4WPost, there was a likely slightly greater increase in Hb(mass) (+4.6%; 0.0, 9.3) and PV (+6%; -5, 18, unclear) in HYP than in NORM. CONCLUSIONS: The combination of heat and hypoxic exposure during sleep/training might offer a promising 'conditioning cocktail' in team sports.


Subject(s)
Altitude , Football/physiology , Acclimatization/physiology , Athletic Performance/physiology , Atmospheric Pressure , Australia , Blood Volume/physiology , Exercise/physiology , Hemoglobins/metabolism , Hot Temperature , Humans , Hypoxia/physiopathology , Running/physiology , Sleep/physiology
13.
J R Soc Med ; 106(6): 224-33, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23761582

ABSTRACT

Member states across the Eastern Mediterranean region face unprecedented health challenges, buffeted by demographic change, a dual disease burden, rising health costs, and the effects of ongoing conflict and population movements - exacerbated in the near-term by instability arising from recent political upheaval in the Middle East. However, health actors in the region are not well positioned to respond to these challenges because of a dearth of good quality health research. This review presents an assessment of the current state of health research systems across the Eastern Mediterranean based on publicly available literature and data sources. The review finds that - while there have been important improvements in productivity in the Region since the early 1990s - overall research performance is poor with critical deficits in system stewardship, research training and human resource development, and basic data surveillance. Translation of research into policy and practice is hampered by weak institutional and financial incentives, and concerns over the political sensitivity of findings. These problems are attributable primarily to chronic under-investment - both financial and political - in Research and Development systems. This review identifies key areas for a regional strategy and how to address challenges, including increased funding, research capacity-building, reform of governance arrangements and sustained political investment in research support. A central finding is that the poverty of publicly available data on research systems makes meaningful cross-comparisons of performance within the EMR difficult. We therefore conclude by calling for work to improve understanding of health research systems across the region as a matter of urgency.


Subject(s)
Health Services Needs and Demand , Research , Financial Support , Humans , Mediterranean Region , Politics
14.
Rev. andal. med. deporte ; 6(2): 85-89, jun. 2013.
Article in Portuguese | IBECS | ID: ibc-113104

ABSTRACT

El estudio tuvo como objetivo examinar las correlaciones entre la dificultad de partidos (dificultad prevista al principio de la temporada [DP] y la dificultad actualizada a cada partido [DA]) y la carga interna de entrenamiento en microciclo anterior al partido (CIT-A) de 12 jugadores profesionales de baloncesto (25,3 ± 4,8, masa corporal 97,6 ± 14,9 kg, altura de 195,8 ± 10,2 cm) durante una temporada de competición. CIT-A se determinó por el método de la PSE del sesión. La relación entre DP, DA y CIT-A se analizó mediante el coeficiente de correlación de Pearson. Se encontró fuerte correlación (r = 0,86) entre DA y PD (p <0,05), así como entre la DP y CIT-A (r = -0,59) y DA y CIT-A (r = -0.65). El coeficiente más alto de correlación entre DA y CIT-A sugiere que la dificultad prevista al comienzo de la temporada (DP) debe actualizarse durante la temporada de competición, y por lo tanto puede proporcionar información valiosa para la planificación y control de las cargas de entrenamiento en microciclos que preceden a los partidos oficiales(AU)


This study aimed to examine the relationships between the difficulty of the matches (difficulty scheduled at the beginning of the season [DBS] and the in-season match difficulty [DIS]) and the weekly internal training load (ITL) in twelve professional male basketball players (25.3 ± 4.8 years, 97.6 ± 14.9 kg, and 195.8 ± 10.2 cm) during a in-season period. DBS was determined before the commencement of the competitive season, and DIS due to reassessing DBS on a weekly basis. ITL was determined by means of session-RPE method. Significant correlations (p < 0.05) were verified between DBS and DIS (r = 0.86), DBS and ITL (- 0.59), and DIS and ITL (- 0.65). The greater coefficient of relationship between DIS and ITL suggest a key role of reassessing the difficulty of the matches on a weekly basis to provide appropriate information to coaches regard planning and monitoring in-season training loads(AU)


Subject(s)
Humans , Male , Female , Young Adult , Basketball/physiology , Exercise Test/instrumentation , Exercise Test/methods , Physical Exertion/physiology , Sports/physiology , Basketball/psychology , Basketball/trends , Basketball/education , Sports/education , Sports/standards , Body Mass Index
15.
Int J Sports Med ; 34(10): 897-903, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23700327

ABSTRACT

Being relatively older and having an advanced biological maturation status have been associated with increased likelihood of selection in young elite soccer players. The aims of the study were to investigate the presence of a relative age effect (RAE) and the influence of birth quarter on anthropometry, biological maturity and anaerobic parameters in 374 elite Belgian youth soccer players. The sample was divided into 3 age groups, each subdivided into 4 birth quarters (BQ). Players had their APHV estimated and height, weight, SBJ, CMJ, sprint 5 and 30 m were assessed. Overall, more players were born in BQ1 (42.3%) compared with players born in BQ4 (13.7%). Further, MANCOVA revealed no differences in all parameters between the 4 BQ's, controlled for age and APHV. These results suggest that relatively youngest players can offset the RAE if they enter puberty earlier. Furthermore, the results demonstrated possible differences between BQ1 and BQ4, suggesting that caution is necessary when estimating differences between players because of large discrepancies between statistical and practical significance. These findings also show that coaches should develop realistic expectations of the physical abilities of younger players and these expectations should be made in the context of biological characteristics rather than chronological age-based standards.


Subject(s)
Athletic Performance , Body Height , Body Weight , Puberty , Soccer/physiology , Adolescent , Age Factors , Analysis of Variance , Child , Humans , Male
16.
Cell Death Differ ; 20(10): 1306-16, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23703321

ABSTRACT

Histone deacetylase (HDAC) is an emergent anticancer target, and HR23B is a biomarker for response to HDAC inhibitors. We show here that HR23B has impacts on two documented effects of HDAC inhibitors; HDAC inhibitors cause apoptosis in cells expressing high levels of HR23B, whereas in cells with low level expression, HDAC inhibitor treatment is frequently associated with autophagy. The mechanism responsible involves the interaction of HDAC6 with HR23B, which downregulates HR23B and thereby reduces the level of ubiquitinated substrates targeted to the proteasome, ultimately desensitising cells to apoptosis. Significantly, the ability of HDAC6 to downregulate HR23B occurs independently of its deacetylase activity. An analysis of the HDAC6 interactome identified HSP90 as a key effector of HDAC6 on HR23B levels. Our results define a regulatory mechanism that involves the interplay between HR23B and HDAC6 that influences the biological outcome of HDAC inhibitor treatment.


Subject(s)
Apoptosis/drug effects , DNA Repair Enzymes/metabolism , DNA-Binding Proteins/metabolism , Histone Deacetylase Inhibitors/pharmacology , Histone Deacetylases/metabolism , Ubiquitin/metabolism , Autophagy/drug effects , Biomarkers, Tumor/genetics , Biomarkers, Tumor/metabolism , Cell Line, Tumor , DNA Repair Enzymes/genetics , DNA-Binding Proteins/genetics , Gene Expression Regulation, Neoplastic , Histone Deacetylase 6 , Histone Deacetylases/genetics , Humans , RNA, Small Interfering/genetics , Transfection
17.
J Sci Med Sport ; 16(6): 550-5, 2013 Nov.
Article in English | MEDLINE | ID: mdl-23332540

ABSTRACT

OBJECTIVES: To examine the usefulness of selected physiological and perceptual measures to monitor fitness, fatigue and running performance during a pre-season, 2-week training camp in eighteen professional Australian Rules Football players (21.9±2.0 years). DESIGN: Observational. METHODS: Training load, perceived ratings of wellness (e.g., fatigue, sleep quality) and salivary cortisol were collected daily. Submaximal exercise heart rate (HRex) and a vagal-related heart rate variability index (LnSD1) were also collected at the start of each training session. Yo-Yo Intermittent Recovery level 2 test (Yo-YoIR2, assessed pre-, mid- and post-camp, temperate conditions) and high-speed running distance during standardized drills (HSR, >14.4 km h(-1), 4 times throughout, outdoor) were used as performance measures. RESULTS: There were significant (P<0.001 for all) day-to-day variations in training load (coefficient of variation, CV: 66%), wellness measures (6-18%), HRex (3.3%), LnSD1 (19.0%), but not cortisol (20.0%, P=0.60). While the overall wellness (+0.06, 90% CL (-0.14; 0.02) AU day(-1)) did not change substantially throughout the camp, HRex decreased (-0.51 (-0.58; -0.45)% day(-1)), and cortisol (+0.31 (0.06; 0.57) nmol L(-1)day(-1)), LnSD1 (+0.1 (0.04; 0.06) ms day(-1)), Yo-YoIR2 performance (+23.7 (20.8; 26.6) m day(-1), P<0.001), and HSR (+4.1 (1.5; 6.6) m day(-1), P<0.001) increased. Day-to-day ΔHRex (r=0.80, 90% CL (0.75; 0.85)), ΔLnSD1 (0.51 (r=0.40; 0.62)) and all wellness measures (0.28 (-0.39; -0.17)

Subject(s)
Football/physiology , Physical Conditioning, Human , Fatigue/psychology , Football/psychology , Humans , Male , Psychometrics , Running/physiology , Young Adult
18.
Biol Sport ; 30(3): 173-80, 2013 Sep.
Article in English | MEDLINE | ID: mdl-24744485

ABSTRACT

The study aim was to investigate the effect of a periodised pre-season training plan on internal training load and subsequent stress tolerance, immune-endocrine responses and physical performance in tennis players. Well-trained young tennis players (n = 10) were monitored across the pre-season period, which was divided into 4 weeks of progressive overloading training and a 1-week tapering period. Weekly measures of internal training load, training monotony and stress tolerance (sources and symptoms of stress) were taken, along with salivary testosterone, cortisol and immunoglobulin A. One repetition maximum strength, running endurance, jump height and agility were assessed before and after training. The periodised training plan led to significant weekly changes in training loads (i.e. increasing in weeks 3 and 4, decreasing in week 5) and post-training improvements in strength, endurance and agility (P < 0.05). Cortisol concentration and the symptoms of stress also increased in weeks 3 and/or 4, before returning to baseline in week 5 (P < 0.05). Conversely, the testosterone to cortisol ratio decreased in weeks 3 and 4, before returning to baseline in week 5 (P < 0.05). In conclusion, the training plan evoked adaptive changes in stress tolerance and hormonal responses, which may have mediated the improvements in physical performance.

19.
J Sports Med Phys Fitness ; 52(5): 501-5, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22976736

ABSTRACT

AIM: Athletes should match their energy intake with expenditure in order to maintain lean body mass. It is also important to consume adequate amounts of antioxidant vitamins and minerals to maintain health. METHODS: To assess the dietary habits of six nationally ranked Australian swimmers physical training load and dietary intake (24 h food recall) and were recorded on a daily basis during a 4 day intensive physical training period. RESULTS: The results showed no significant difference between energy intake and expenditure (P=0.58) or the amount of carbohydrate consumed (P=0.14) compared to the Australian recommended daily intake (RDI). Athletes reported a significantly greater intake of vitamin A (P<0.01), vitamin C (P<0.01), vitamin E (P<0.01) and protein (P<0.01) than the RDI. CONCLUSION: It was concluded that these elite swimmers have an adequate dietary intake to allow for optimal physical training and performance.


Subject(s)
Antioxidants/administration & dosage , Athletes , Feeding Behavior , Nutritional Status , Physical Education and Training , Swimming/physiology , Body Composition , Dietary Supplements , Energy Intake , Energy Metabolism , Humans , Male , Statistics, Nonparametric , Young Adult
20.
Int J Sports Med ; 33(12): 987-93, 2012 Dec.
Article in English | MEDLINE | ID: mdl-22791620

ABSTRACT

The aims of the study were to investigate the presence of a relative age effect and the influence of birth quarter on anthropometric characteristics, an estimation of biological maturity and performance in the Yo-Yo Intermittent Recovery Test level 1 in 606 elite, Flemish youth soccer players. The sample was divided into 5 chronological age groups (U10-U19), each subdivided into 4 birth quarters. Players had their APHV estimated and height, weight and Yo-Yo IR1 performance were assessed. Differences between quarters were investigated using uni- and multivariate analyses. Overall, significantly (P<0.001) more players were born in the first quarter (37.6%) compared to the last (13.2%). Further, no significant differences in anthropometric variables and Yo-Yo IR1 performance were found between the 4 birth quarters. However, there was a trend for players born in the first quarter being taller and heavier than players born in the fourth quarter. Players born in the last quarter tended to experience their peak in growth earlier, this may have enabled them to compete physically with their relatively older peers. Our results indicated selection procedures which are focused on the formation of strong physical and physiological homogeneous groups. Relative age and individual biological maturation should be considered when selecting adolescent soccer players.


Subject(s)
Age Factors , Athletic Performance/physiology , Soccer/physiology , Adolescent , Anthropometry , Belgium , Humans , Longitudinal Studies , Male , Physical Endurance/physiology , Physical Exertion/physiology
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