Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Am J Clin Pathol ; 114(1): 47-56, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10884799

ABSTRACT

Accurate and precise platelet counts are important for patients with severe thrombocytopenia or who are receiving chemotherapy. We developed a novel flow cytometric analysis of platelets that may be particularly valuable for assessing the necessity for platelet transfusions. This ImmunoPlt (CD61) assay is based in part on CD61 monoclonal antibody labeling and has been automated and implemented on the CELL-DYN 4000 hematology analyzer. It is well suited for thrombocytopenic specimens, since it reduces interference by nonplatelet particles. It takes less than 5 minutes from closed-tube aspiration to report. Data for more than 350 thrombocytopenic specimens demonstrate that the ImmunoPlt (CD61) assay is more accurate than the optical scatter or the impedance count for specimens with platelet counts between 1 and 60 x 10(3)/microL (1 and 60 x 10(9)/L). The ImmunoPlt (CD61) assay is more precise than the optical scatter or the impedance count for specimens with platelet counts between 1 and 50 x 10(3)/microL (1 and 50 x 10(9)/L).


Subject(s)
Blood Platelets/immunology , Hematology/instrumentation , Immunoassay/methods , Immunoassay/standards , Antibodies, Monoclonal , Antigens, CD/immunology , Artifacts , Automation , Blood Platelets/pathology , Drug Stability , Humans , Integrin beta3 , Microscopy, Phase-Contrast , Platelet Count , Platelet Glycoprotein GPIIb-IIIa Complex/immunology , Platelet Glycoprotein GPIb-IX Complex/immunology , Platelet Membrane Glycoproteins/immunology , Time Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...