Verbal Quantifiers and Communicating Painkiller Side Effect Risk.

The two studies reported here explore the use of verbal quantifiers (e.g., "common") as an alternative to the numerical presentation of risk information about prescription drugs. Guided by work on adverb-adjective pairs (Study 1) and research on fuzzy trace theory (Study 2), predictions are made about participants' risk perceptions after reading verbal presentations of a medication's side effects. Participants report their perceptions about the drug's side effects' occurrence among users. In Study 1, pairs of adverbs and adjectives (e.g., "very rare") are used in contrast to adjectives alone to convey numerical risk information. In Study 2, severity and more general risk perception measures are added to better understand bottom-down schema processing. Findings show that individuals vastly overestimate the likelihood of side effects occurring, compared with the European Union's CIOMS III recommendations (e.g., "rare" side effects affect .01-.1% of users), and demonstrate support for the differences between gist and verbatim processing of risk information.

Risk, Stigma, Trustworthiness, and Citizen Participation-A Multifaceted Analysis of Media Coverage of Dioxin Contamination in Midland, Michigan.

In the United States, more than 200 communities are designated by the U.S. Environmental Protection Agency as areas of concern for dioxins. Informing the public about potential risks associated with dioxins and delivering information about how to avoid such risks are essential activities. News coverage of environmental and health problems affects how members of the public assess those problems in terms of both severity and how they are understood, as well as the extent of attention given to the problem by policy-makers. To contextualize public and institutional responses to dioxin contamination and remediation in a dioxin-affected community, we assessed 176 newspaper articles published over 30 years concerning dioxin contamination in Midland, Michigan, in terms of risk, trust in institutions, environmental stigma, and citizen participation. Articles about dioxin contamination and remediation in Midland appeared in both domestic and international newspapers. Domestically, both national and local newspapers covered this issue. The risks for human health and the environment caused by exposure to dioxins were widely covered, with much less media attention given to the trustworthiness of the organizations responsible for managing the risk, environmental stigma, and citizen participation. News coverage of these four themes also changed significantly overtime. Overall, our findings highlight the important role of local news media in communicating risk information, guiding safe behaviors, and facilitating community-level decision-making.

The Effect of Dioxin Contamination and Remediation on Property Values.

Loss of property value is a major concern in communities faced with the toxic byproducts of industrial practices. Even after site remediation, stigma may persist and negatively affect market values of residential properties. To study the effects of contamination and of remediation on property values in Midland, Michigan, where dioxins have been released into the environment through the incineration of contaminated waste and the discharge of contaminated water for many years, records of assessed value were obtained for 229 homes within the same neighborhood for the previous 18 years. A multilevel, longitudinal analysis was conducted to determine if there was a relationship between level of dioxin and assessed value after controlling for housing characteristics. Remediated and un-remediated properties saw increases in value at a similar rate over time. However, a property's level of dioxin was found to have a small, significant, and negative relationship with assessed value, and this negative effect was present regardless if a home had been remediated or not. These results suggest that while environmental remediation may be effective at removing the contamination, its economic effects may persist for a longer period of time.

Working with Institutional Stakeholders: Propositions for Alternative Approaches to Community Engagement.

Community engagement is a vital aspect of addressing environmental contamination and remediation. In the United States, the Superfund Research Program (SRP) forms groups of academic researchers from the social and physical sciences into Community Engagement Cores (CECs) and Research Translation Cores (RTCs), which focus on various aspects of informing and working with communities during and through the resolution of environmental crises. While this work typically involves engaging directly with members of affected communities, no two situations are the same. In some cases, alternative approaches to community engagement can be more appropriate for community improvement than traditional approaches. In particular, when research teams become involved in contamination crises at a late point in the process, their contributions can be better directed at supporting and reinforcing the work of institutional stakeholders charged with remediating pollution. Relevant factors include issue fatigue among a local population, and contamination that is due to a major employer. Supported by literature and experience, we offer several propositions that we believe lay out conditions that warrant such an approach by academic teams, rather than their direct engagement with unaffiliated individuals in communities.

Study of landfill leachate as a sustainable source of water and nutrients for algal biofuels and bioproducts using the microalga Picochlorum oculatum in a novel scalable bioreactor.

High water demand is a major challenge for the algae industry, so cultivating algae in wastewater can have the double benefit of biomass production and water remediation. The use of landfill leachate (LL), which is wastewater generated in landfills, was investigated to grow the microalga Picochlorum oculatum in a novel horizontal bioreactor (HBR), a low-cost modular cultivation system that reduces water evaporation and contamination risk thanks to its enclosed design. Pilot-scale (150 L) and commercial-scale (2000 L) HBRs that were operated outdoors in Florida using LL in batch and semi-continuous modes generated high cell density cultures (1.7·109 cells mL-1) and reached up to 1.9 g L-1 of dry biomass suitable for biofuel production. Demonstrating the ability of ample non-potable water sources, such as LL, to support algae cultivation is essential for improving the sustainability and cost-effectiveness of commercial algal biofuels and bioproducts, as freshwater resources become increasingly scarce.

Diffusion Of Innovations Theory, Principles, And Practice.

Aspects of the research and practice paradigm known as the diffusion of innovations are applicable to the complex context of health care, for both explanatory and interventionist purposes. This article answers the question, "What is diffusion?" by identifying the parameters of diffusion processes: what they are, how they operate, and why worthy innovations in health care do not spread more rapidly. We clarify how the diffusion of innovations is related to processes of dissemination and implementation, sustainability, improvement activity, and scale-up, and we suggest the diffusion principles that can be readily used in the design of interventions.

Characterization of two neuronal subclasses through constellation pharmacology.

Different types of neurons diverge in function because they express their own unique set or constellation of signaling molecules, including receptors and ion channels that work in concert. We describe an approach to identify functionally divergent neurons within a large, heterogeneous neuronal population while simultaneously investigating specific isoforms of signaling molecules expressed in each. In this study we characterized two subclasses of menthol-sensitive neurons from cultures of dissociated mouse dorsal-root ganglia. Although these neurons represent a small fraction of the dorsal-root ganglia neuronal population, we were able to identify them and investigate the cell-specific constellations of ion channels and receptors functionally expressed in each subclass, using a panel of selective pharmacological tools. Differences were found in the functional expression of ATP receptors, TRPA1 channels, voltage-gated calcium-, potassium-, and sodium channels, and responses to physiologically relevant cold temperatures. Furthermore, the cell-specific responses to various stimuli could be altered through pharmacological interventions targeted to the cell-specific constellation of ion channels expressed in each menthol-sensitive subclass. In fact, the normal responses to cold temperature could be reversed in the two neuronal subclasses by the coapplication of the appropriate combination of pharmacological agents. This result suggests that the functionally integrated constellation of signaling molecules in a particular type of cell is a more appropriate target for effective pharmacological intervention than a single signaling molecule. This shift from molecular to cellular targets has important implications for basic research and drug discovery. We refer to this paradigm as "constellation pharmacology."

Postnatal administration of D1 dopamine agonist reverses neonatal dopaminergic lesion-induced changes in striatal enkephalin and substance P systems.

The present study examined the effects of postnatal dopamine (DA) receptor stimulation on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of rats, lesioned as neonates with 6-hydroxydopamine (6-OHDA, intracisternally) on the third postnatal day. D1 agonist, SKF-38393 or D2 agonist, LY-171555 (also known as quinpirole) was administered s.c. twice daily for 14 days, beginning 24 h after 6-OHDA administration. The animals were sacrificed at 60 days of age, and the concentrations of striatal DA, SP, and ME were determined by HPLC or radioimmunoassay. As expected, 6-OHDA induced a severe loss of DA, an increase in ME, and a decrease in SP. SKF-38393, but not, quinpirole significantly reversed the lesion-induced changes in ME and SP levels. The results indicate an important role for D1 receptors in the postnatal development of ME and SP systems in the striatum. These studies are relevant to our further understanding of potential early interventions in the progression and expression of DA deficiency states such as Parkinsonism and Lesch-Nyhan disease.

A clinical pilot study of the dimensional accuracy of double-arch and complete-arch impressions.

STATEMENT OF PROBLEM: It has been suggested that articulated casts fabricated with the double-arch impression technique may have superior occlusal accuracy than those fabricated with a single complete-arch impression. However, lack of tray rigidity may lead to flexure of the impression/tray complex, resulting in inaccurate dies in the bucco-lingual dimension. PURPOSE: This clinical pilot study compared the dimensions of dies fabricated with 3 types of double-arch impressions to dies fabricated with the conventional complete-arch, custom tray method. MATERIAL AND METHODS: Thirty-five addition silicone impressions were made of cast metal copings cemented onto natural teeth prepared as complete-crown abutments. Four combinations of tray types and impression material viscosity were used: (1) complete-arch, custom acrylic trays loaded with heavy-bodied material; (2) double-arch, disposable plastic trays loaded with heavy-bodied material; (3) double-arch, disposable plastic trays loaded with putty material; and (4) double-arch, reusable brass metal trays loaded with heavy-bodied material. Immediately prior to tray insertion, light-bodied impression material was syringed over all copings as a wash. The 4 copings were fabricated from cast gold and simulated metal-ceramic complete-crown thimbles with polished collars and had "projections" on the occlusal surfaces. The impressions were poured in type IV die-stone. Bucco-lingual and inter-abutment dimensions were measured. The differences between the stone dimensions and cast metal control dimensions were calculated and converted to percent dimensional change. The data were analyzed with 1-way analysis of variance, Student t tests, and Mann-Whitney tests (P<.05). RESULTS: The plastic double-arch tray loaded with heavy-viscosity addition silicone and a low-viscosity wash produced the least accurate combination inter- and intra-abutment dimensions. For this protocol, 1.17% mean dimensional change was recorded. This result was significantly different than that obtained for the other 3 impression methods tested. No significant differences were found between the complete-arch method and protocols in which putty was loaded in a plastic or metal tray. CONCLUSION: Within the limitations of this pilot study, the more rigid tray/impression material combinations more accurately replicated stone dies.