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Acad Radiol ; 23(8): 935-9, 2016 08.
Article in English | MEDLINE | ID: mdl-27209264

ABSTRACT

RATIONALE AND OBJECTIVES: We sought to determine if lung densities derived from computed tomography scans could be used to identify patients with pulmonary venous hypertension (Group II pulmonary hypertension [PH]), and to compare the performance of this metric with previously described metrics. MATERIALS AND METHODS: Patients were retrospectively included from a single-center cohort of patients with aortic stenosis being evaluated for transcatheter aortic valve replacement from April 2009 to July 2014. Fifty-four patients met inclusion criteria. Thirty-three had PH (pulmonary arterial pressure [PAP] ≥25 mmHg). Thirty-two had Group II PH (pulmonary capillary wedge pressure [PCWP] ≥15 mmHg). Mean lung density (mLD) was measured from chest computed tomography scans using semi-automated techniques. Aortic diameter (mAo) and main pulmonary artery diameter (mPA) were measured manually. These metrics were correlated with PAP and PCWP values. RESULTS: mLD was significantly correlated with PCWP (R = 0.45, P = .0006) and significantly higher in patients with elevated PCWP (P = .006). mPA was weakly correlated with PCWP (R = 0.28, P = .04), but not significantly different in patients with elevated PCWP. mPA/mAo was not significantly correlated with PCWP, nor was it significantly different in patients with elevated PCWP. mLD, mPA, and mPA/mAo were all significantly correlated with PAP and were significantly higher in patients with PH. CONCLUSIONS: Of all metrics, only mLD was significantly correlated with PCWP and served to differentiate patients with elevated and normal PCWP. As such, mLD may contribute to a noninvasive biomarker of pulmonary venous hypertension.


Subject(s)
Hypertension, Pulmonary/diagnostic imaging , Hypertension, Pulmonary/physiopathology , Lung/diagnostic imaging , Lung/physiopathology , Tomography, X-Ray Computed/methods , Aged, 80 and over , Diagnosis, Differential , Female , Humans , Male , Pilot Projects , Reproducibility of Results , Retrospective Studies
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