1.
Synlett
; 28(9): 1101-1105, 2017 Jun.
Article
in English
| MEDLINE
| ID: mdl-31592212
ABSTRACT
A convergent synthesis of a C1-C23 fragment of the archazolids has been completed based on a high yielding Stille coupling to costruct the substituted Z,Z,E-conjugated triene. After removal of the protecting groups, the resulting tetrol exhibited evidence for inhibition of the vacuolar-type ATPase (V-ATPase) but not cyclooxygenase (COX) inhibitory activity.