1.
Bioorg Med Chem Lett
; 14(24): 6053-6, 2004 Dec 20.
Article
in English
| MEDLINE
| ID: mdl-15546728
ABSTRACT
We exploit the concept of using hydrogen bonds to link multiple ligands for maintaining simultaneous interactions with polyvalent binding sites. This approach is demonstrated by the syntheses and evaluation of pseudo-bivalent ligands as potent inhibitors of human beta-tryptase.