Association of physical activity on memory interference: Boston Puerto Rican Health Study.

Background : The objective of this study was to evaluate the association between habitual physical activity engagement on memory interference. The present analysis used cross-sectional data from the Boston Puerto Rican Health Study (n=1,241; mean age= 57.2; 72.1% female). Methods : Physical activity was evaluated via self-report. Memory interference was evaluated using a word-list paradigm. The memory task included learning a list of 16 words (List A; 5 trials), followed by a distractor list (List B), and then an immediate recall of List A. Proactive interference occurs when preceding stimuli (e.g., Trial 1 and Trial 5 of List A) interferes with performance on a subsequent stimuli (List B). Retroactive interference occurs when subsequent stimuli (List B) interferes with the recall of previously encoded stimuli (Trial 5). Results : For proactive interference, there was no association between physical activity and the difference between performance on List B and Trial 1 of List A (ß=0.00001; P =0.96). Similarly, for retroactive interference, there was no association between physical activity and the difference between the short delay recall and Trial 5 of List A (ß=0.0002; P=0.50). Conclusion : The present study did not observe an association between habitual physical activity on attenuating memory interference.

The Impact of Acute Exercise Timing on Memory Interference.

This study evaluated whether the timing of acute exercise can attenuate a memory interference effect. Across two experiments, participants completed an AB/AC memory task. Participants studied eight word pairs; four denoted AB (e.g., Hero - Apple) and four control (DE) pairs. Following this List 1, participants studied eight additional word pairs (List 2); four denoted AC, re-using words from the AB pairs (e.g., Hero - Project) and four control (FG) pairs. Following their study of both lists, participants completed a cued recall assessment. In Experiment 1 (N = 100), an acute exercise bout occurred before the AB/AC memory interference task, and the participants' three lab visits (successive conditions) were control, moderate-intensity (50% HRR; heart rate reserve) exercise, and vigorous-intensity (80% HRR) exercise. In Experiment 2 (N = 68), the acute exercise occurred between List 1 and List 2, and the participants' two lab visits (successive conditions) were a (80% HRR) vigorous-intensity exercise visit and a control visit. Across both experiments, we observed evidence of both proactive and retroactive interference (p < .05), but acute exercise, regardless of intensity, did not attenuate this interference (p > .05). Acute moderate-intensity exercise was better than control or vigorous-intensity exercise in enhancing associative memory (p < .05), independent of interference. In Experiment 2, vigorous intensity exercise was associated with more pronounced interference (p < .05). Our results suggest that acute exercise can enhance associative memory performance, with no attenuation of interference by exercise.

Hypothesized Mechanisms Through Which Exercise May Attenuate Memory Interference.

In this paper we introduce a mechanistic model through which exercise may enhance episodic memory, specifically via attenuating proactive and retroactive memory interference. We discuss the various types of memory, different stages of memory function, review the mechanisms behind forgetting, and the mechanistic role of exercise in facilitating pattern separation (to attenuate memory interference).