ABSTRACT
Many centres continue to decline percutaneous lung biopsy (PLB) in patients with poor lung function (particularly FEV1 <1â L) due to the theoretically increased risk of pneumothorax. This practice limits access to novel lung cancer therapies and minimally invasive surgical techniques. Our retrospective single-centre analysis of 212 patients undergoing PLB, all performed prospectively and blinded to lung function, demonstrates that using ambulatory Heimlich valve chest drain (HVCD) to treat significant postbiopsy pneumothorax facilitates safe, diagnostic, early discharge lung biopsy irrespective of lung function with neither FEV1 <1â L nor transfer coefficient for carbon monoxide (TLCO) <40% predicted shown to be independent predictors of HVCD insertion or pneumothorax outcomes. Incorporating ambulatory HVCD into standard PLB practice thereby elegantly bridges the gap that currently exists between tissue diagnosis in patients with poor lung function and the advanced therapeutic options available for this cohort.
Subject(s)
Biopsy/instrumentation , Lung Neoplasms/pathology , Lung Neoplasms/therapy , Pneumonectomy , Radiosurgery , Aged , Aged, 80 and over , Antineoplastic Agents/therapeutic use , Biopsy/adverse effects , Biopsy/methods , Female , Humans , Male , Outpatients , Pneumonectomy/methods , Prospective Studies , Radiosurgery/methods , Retrospective Studies , Treatment OutcomeSubject(s)
POEMS Syndrome/diagnosis , POEMS Syndrome/drug therapy , Adult , Antineoplastic Agents/therapeutic use , Boronic Acids/therapeutic use , Bortezomib , Cyclophosphamide/therapeutic use , Dexamethasone/therapeutic use , Diagnosis, Differential , Drug Therapy, Combination , Humans , Male , Pyrazines/therapeutic use , Rare DiseasesABSTRACT
This research measured the physical and psychosocial effects of the practice of Benson's relaxation technique by male postmyocardial infarction patients enrolled in a cardiac rehabilitation program and determined if the patient's behavioral style (Type A or Type B) was related to the outcomes. Twenty-seven subjects completed the experimental condition; 30, the control condition. Outcome measures included blood pressure, heart rate, aerobic conditioning level (MET level), and psychosocial functioning, as measured by the Sickness Impact Profile. Repeated measures analysis of variance was used to determine if relaxation therapy and/or behavior style had an effect on measures of the effectiveness of cardiac rehabilitation. The practice of relaxation was found to have a significant effect on diastolic blood pressure. Behavior style was unrelated to the outcome measures.
Subject(s)
Myocardial Infarction/rehabilitation , Relaxation Therapy , Adult , Aged , Blood Pressure , Heart Rate , Humans , Male , Middle Aged , Myocardial Infarction/physiopathology , Myocardial Infarction/psychology , Type A PersonalityABSTRACT
The use of time-lapse and normal speed photography as a tool in evaluating the effect of cage size on physical activity in the beagle dog was examined. Normal speed motion pictures also served to demonstrate the degree of physical activity possible within specific sized cages, and the effect of changes in external activity on the dogs' activity within the cage. Viewing of these films showed that specific activity measurements can be made, providing a feasible scientific method for evaluating cage activity in a wide range of cage sizes. Physiological data collected over the course of this experiment from dogs housed in 2 different sized cages failed to show a cause-and-effect relationship.
