ABSTRACT
The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF mutation in both malignancies raises physiopathological considerations and might offer unique therapeutic strategies for this group of patients.
ABSTRACT
Metastases to the spleen are rare but have been reported for different tumor entities, including breast cancer, lung cancer, colorectal cancer, ovarian cancer, and melanoma. As an isolated event, splenic metastasis from non-small-cell lung cancer (NSCLC) is exceedingly rare. Until now, only 28 cases have been reported in the medical literature. We report the case of a 66-year-old woman with NSCLC (adenocarcinoma) who presented with a synchronous, isolated splenic metastasis. Operative removal of both primary tumor and metastasis was not possible due to multiple comorbidities. Therefore, treatment was limited to combined systemic chemotherapy and simultaneous radiation of the primary tumor, which led to partial remission of the disease. Isolated metastasis to the spleen in NSCLC has been reported only 28 times in the medical literature, most often in male patients with right-sided lung tumors, most of which were adenocarcinomas. The majority of patients were asymptomatic with respect to splenic metastasis. About half of the reported cases were isolated metachronous splenic metastases. Splenectomy seems to confer a survival advantage. We review the pertinent medical literature.
ABSTRACT
El presente documento refiere: Evaluación y Daños de Necesidades tomando en cuenta los siguentes items: Zona afectadas: Tipo de evento: Día y Hora de ocurrencia: Vías de acceso desponibles para la zona afectada: Otro medio de comunicación: Daños generales: Daños de Salud:Acciones prioritarias para el control de la situación y la atención de la salud: Coordinaciones realizadas hasta el momento: Requerimientos de apoyo para ejecución de acciones prioritarias.
Subject(s)
Male , Female , Humans , Evaluation Study , Damage Assessment , Disaster Evaluation , Needs Assessment , Laboratory and Fieldwork Analytical Methods , BoliviaABSTRACT
El informe presente refiere: Resumen de emergencias atendidas en el año 2001: Tomando en cuenta los siguientes items: Fecha: Distrito: Municipio Localidad o Zona: Tipos de desastres: Número de afectados: Número de familias: Viviendas afectadas: Viviendas destruidas: Dotación de insumos: Actividades ejecutadas.
