Mutual information of multiple rhythms in schizophrenia.

Interactions between different cortical rhythms, such as slow and fast oscillations, have been hypothesized to underlie many cognitive functions. In patients diagnosed with schizophrenia, there is some evidence indicating that the interplay between slow and fast oscillations might be impaired or disrupted. In this study, we investigated multiple oscillatory interactions in schizophrenia using a novel approach based on information theory. This method allowed us to investigate interactions from a new perspective, where two or more rhythm interactions could be analyzed at the same time. We calculated the mutual information of multiple rhythms (MIMR) for EEG segments registered in resting state. Following previous studies, we focused on rhythm interactions between theta, alpha, and gamma. The results showed that, in general, MIMR was higher in patients than in controls for alpha-gamma and theta-gamma couplings. This finding of an increased coupling between slow and fast rhythms in schizophrenia may indicate complex interactions in the Default Mode Network (DMN) related to hyperactivation of internally guided cognition.

Alpha and gamma EEG coherence during on-task and mind wandering states in schizophrenia.

OBJECTIVE: Electroencephalographic (EEG) coherence is one of the most relevant physiological measures used to detect abnormalities in patients with schizophrenia. The present study applies a task-related EEG coherence approach to understand cognitive processing in patients with schizophrenia and healthy controls. METHODS: EEG coherence for alpha and gamma frequency bands was analyzed in a group of patients with schizophrenia and a group of healthy controls during the performance of an ecological task of sustained attention. We compared EEG coherence when participants presented externally directed cognitive states (On-Task) and when they presented cognitive distraction episodes (Mind-Wandering). RESULTS: Results reflect cortical differences between groups (higher coherence for schizophrenia in the frontocentral and fronto-temporal regions, and higher coherence for healthy-controls in the postero-central regions), especially in the On-Task condition for the alpha band, compared to Mind-Wandering episodes. Few individual differences in gamma coherence were found. CONCLUSIONS: The current study provides evidence of neurophysiological differences underlying different cognitive states in schizophrenia and healthy controls. SIGNIFICANCE: Differences between groups may reflect inhibitory processes necessary for the successful processing of information, especially in the alpha band, given its role in cortical inhibition processes. Patients may activate compensatory inhibitory mechanisms when performing the task, reflected in increased coherence in fronto-temporal regions.

Examining Motor Anticipation in Handwriting as an Indicator of Motor Dysfunction in Schizophrenia.

Dysfunction in motor skills can be linked to alterations in motor processing, such as the anticipation of forthcoming graphomotor sequences. We expected that the difficulties in motor processing in schizophrenia would be reflected in a decrease of motor anticipation. In handwriting, motor anticipation concerns the ability to write a letter while processing information on how to produce the following letters. It is essential for fast and smooth handwriting, that is, for the automation of graphomotor gestures. In this study, we examined motor anticipation by comparing the kinematic characteristics of the first l in the bigrams ll and ln written on a digitiser. Previous studies indicated that the downstroke duration of the first l is modulated by the anticipation of the local constraints of the following letter. Twenty-four adult individuals with diagnosis of schizophrenia and 24 healthy adults participated in the study. The classic measures of duration (sec), trajectory (cm), and dysfluency (velocity peaks) were used for the kinematic analysis of the upstroke (US) and downstroke (DS). In the control group, the duration of the downstroke of the l was longer in ln than ll (US: ln = ll; DS: ln > ll) whereas no differences were found for the group with schizophrenia. Likewise, the control group showed a longer DS trajectory for the l of ln than ll in downstrokes, while the group of patients failed to show this effect. These results suggest that the motor alterations in patients with schizophrenia could also affect their ability for motor anticipation.