Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
BMJ Open ; 6(6): e010960, 2016 06 29.
Article in English | MEDLINE | ID: mdl-27357195

ABSTRACT

OBJECTIVE: The goal of the current study was to empirically compare successive cohorts of treatment-seeking smokers who enrolled in randomised clinical trials in a region of the USA characterised by strong tobacco control policies and low smoking prevalence, over the past three decades. DESIGN: Retrospective treatment cohort comparison. SETTING: Data were collected from 9 randomised clinical trials conducted at Stanford University and the University of California, San Francisco, between 1990 and 2013. PARTICIPANTS: Data from a total of 2083 participants were included (Stanford, n=1356; University of California San Francisco, n=727). PRIMARY AND SECONDARY OUTCOMES: One-way analysis of variance and covariance, χ(2) and logistic regression analyses were used to examine relations between nicotine dependence, cigarettes per day, depressive symptoms and demographic characteristics among study cohorts. RESULTS: Similar trends were observed at both settings. When compared to earlier trials, participants in more recent trials smoked fewer cigarettes, were less nicotine-dependent, reported more depressive symptoms, were more likely to be male and more likely to be from a minority ethnic/racial group, than those enrolled in initial trials (all p's<0.05). Analysis of covariances revealed that cigarettes per day, nicotine dependence and current depressive symptom scores were each significantly related to trial (all p's<0.001). CONCLUSIONS: Our findings suggest that more recent smoking cessation treatment-seeking cohorts in a low prevalence region were characterised by less smoking severity, more severe symptoms of depression and were more likely to be male and from a minority racial/ethnic group.


Subject(s)
Public Health , Smokers/psychology , Smoking Cessation/statistics & numerical data , Smoking/adverse effects , Adolescent , Adult , Ethnicity , Female , Health Knowledge, Attitudes, Practice , Humans , Male , Middle Aged , Patient Acceptance of Health Care/psychology , Prevalence , Randomized Controlled Trials as Topic , Retrospective Studies , San Francisco/epidemiology , Smokers/education , Smoking Cessation/psychology
2.
Paediatr Drugs ; 14(2): 91-108, 2012 Apr 01.
Article in English | MEDLINE | ID: mdl-22248234

ABSTRACT

Adolescent smoking remains a public health problem. Despite concerns regarding adolescent nicotine dependence, few well-designed smoking cessation studies have been conducted with teen smokers. This is particularly true regarding pharmacologic treatments for nicotine dependence. Currently, pharmacologic aids are not recommended for treating adolescent nicotine dependence, as efficacy has not been shown in this population. This review includes studies that have examined the efficacy of pharmacotherapy for smoking abstinence and/or reduction in cigarette consumption among adolescent smokers who want to quit smoking, laboratory-based adolescent studies that have examined the efficacy of these medications in reducing cravings and/or withdrawal symptoms, and/or studies that have assessed the tolerability of medications for smoking cessation in adolescent smokers. It provides information on the pharmacologic action of each medication, the efficacy of each medication for adolescent smoking cessation, the tolerability of each medication based on reported adverse events, and compliance with the medication protocols. Thirteen relevant articles were identified and included in the review. Nicotine patch (NP), nicotine gum, nicotine nasal spray, bupropion, and varenicline have been studied in adolescent smokers. The adverse events reported in the studies on pharmacology for adolescent smoking suggest that the side effect profiles for nicotine replacement therapy, bupropion, and varenicline are similar to those reported in adult studies. There is some evidence of efficacy of NP and bupropion at the end of treatment (efficacy of varenicline has not been assessed), but none of the medications included in this review were efficacious in promoting long-term smoking cessation among adolescent smokers. It is noted that many of the study protocols did not follow the recommended dose or length of pharmacotherapy for adults, rendering it difficult to determine the true efficacy of medication for adolescent smoking cessation. Future efficacy studies are warranted before recommending pharmacotherapy for adolescent smoking cessation.


Subject(s)
Benzazepines/therapeutic use , Bupropion/therapeutic use , Nicotine/therapeutic use , Nicotinic Agonists/therapeutic use , Prescription Drugs/therapeutic use , Quinoxalines/therapeutic use , Smoking Cessation/methods , Substance Withdrawal Syndrome/prevention & control , Tobacco Use Cessation Devices/statistics & numerical data , Adolescent , Benzazepines/administration & dosage , Benzazepines/adverse effects , Bupropion/administration & dosage , Bupropion/adverse effects , Clinical Trials as Topic , Dopamine Uptake Inhibitors/therapeutic use , Humans , Nicotine/administration & dosage , Nicotine/adverse effects , Nicotinic Agonists/administration & dosage , Nicotinic Agonists/adverse effects , Patient Compliance/statistics & numerical data , Quinoxalines/administration & dosage , Quinoxalines/adverse effects , Randomized Controlled Trials as Topic , Safety , Substance Withdrawal Syndrome/drug therapy , Treatment Outcome , Varenicline
SELECTION OF CITATIONS
SEARCH DETAIL
...