ABSTRACT
An epidemiological study of Ascaris lumbricoides infections was carried out in primary school children aged 5-16 yr from Ile-Ife, Nigeria. Intensity of infection was assessed directly by means of counting worms passed during a 48-hr period after chemotherapy. Reinfection patterns of A. lumbricoides were assessed at 2 6-mo intervals and statistical evidence of predisposition to infection status was obtained. An investigation of 3 groups of children who were judged to be predisposed not to be infected, to be lightly infected, and to be heavily infected was undertaken. Assignment to the groups was based upon the mean worm burden plus 1 SD above the mean, measured at 2 6-mo intervals. The distribution of class I human leucocyte antigens among the 3 groups of children was described. None of the children who were predisposed to remain uninfected was found to possess the A30/31 antigens in contrast to those children who remained infected.
Subject(s)
Ascariasis/immunology , Ascaris lumbricoides/immunology , Adolescent , Animals , Ascariasis/epidemiology , Ascariasis/genetics , Child , HLA Antigens/blood , Humans , Immunity, Innate/genetics , Nigeria/epidemiology , RecurrenceSubject(s)
Genes , HLA Antigens/genetics , Major Histocompatibility Complex , Animals , Genes, MHC Class I , Genes, MHC Class II , Humans , Mice , Transplantation ImmunologyABSTRACT
Various batches of intravenous gammaglobulin (IV-IgG) were found to contain antibodies with the capacity to block human peripheral blood lymphocyte receptors for the Fc region of IgG i.e., Fc gamma-receptors (Fc gamma Rs). The level of Fc gamma R-blocking produced was found to vary considerably from batch to batch and from lymphocyte donor to donor. IgG purified from normal human serum pooled from only 20 donors was also found to produce significant Fc gamma R-blockade. Analysis of the individual contributors to this normal IgG pool indicated that Fc gamma R-blocking antibodies may in fact be auto-antibodies.
Subject(s)
Immunoglobulin G/immunology , Lymphocytes/immunology , Receptors, Fc/immunology , Adult , Alkylation , Antibody-Dependent Cell Cytotoxicity , Female , Humans , In Vitro Techniques , Male , Oxidation-Reduction , Receptors, IgG , Rosette Formation , Sex Characteristics , UltracentrifugationSubject(s)
Cytotoxicity Tests, Immunologic , Histocompatibility Testing , Kidney Transplantation , Antigen-Antibody Reactions , Cadaver , Cell Line , Cells, Cultured , Graft Rejection , Graft vs Host Reaction , Histocompatibility Antigens/analysis , Humans , Kidney/immunology , Leukemia, Lymphoid/immunology , Lymphocytes/immunology , Tissue Donors , Transplantation, HomologousSubject(s)
Histocompatibility Antigens/radiation effects , Lymphocyte Activation , Lymphocytes/radiation effects , Radiation Effects , Animals , Blood , Cattle , Cell Line , Culture Media , Epitopes , Female , Fetus , Histocompatibility Testing , Humans , Kinetics , Lymphocytes/metabolism , Male , Penicillins , Streptomycin , Thymidine/metabolism , TritiumSubject(s)
Histocompatibility Testing , Lymphocytes/immunology , Absorption , Antibodies, Viral/analysis , Cell Line , Cells, Cultured , Cytotoxicity Tests, Immunologic , Herpesvirus 4, Human , Histocompatibility Antigens/analysis , Humans , Infectious Mononucleosis/immunology , Leukemia, Lymphoid/immunologySubject(s)
Dermatitis Herpetiformis/immunology , Immunoglobulin M/analysis , Skin Diseases/immunology , gamma-Globulins/analysis , Adolescent , Adult , Aged , Biopsy , Child , Dapsone/therapeutic use , Dermatitis Herpetiformis/drug therapy , Female , Humans , Intestinal Mucosa , Male , Middle Aged , Psoriasis/immunologyABSTRACT
A controlled cultural and serological investigation of mycoplasmas in recurrent oral ulceration was undertaken. No evidence for an aetiological relationship between oral mycoplasmas and this condition was obtained.Mycoplasmas, principally M. orale, were frequently recovered from the oral cavities of individuals with natural teeth, but rarely from edentulous subjects.
