ABSTRACT
Decreased platelet count and platelet adhesiveness as well as increased values of the protamine sulfate test were found in 26 patients with septic abortion (9 of them anuric). Serum fibrinogen-fibrin related antigen (FR-antigen) values, detected in 13 patients (7 of them anuric) were greatly increased although euglobulin lysis time was rather prolonged (more than 400 min). Less increased FR-antigen values were noted in 15 cirrhotic patients with enhanced fibrinolytic activity in the circulating blood (euglobulin lysis time less than 120 min). These findings suggest that an important increase of FR-antigen in serum is likely to indicate a local fibrinolytic response to an initial coagulation event. Since platelet count and adhesiveness as well as FR-antigen and protamine sulfate test were similarly changed in patients with septic abortion who developed acute renal failure and in those who did not, it seems that the above mentioned parameters are not predictive for the evolution of thrombotic deposits and for possible renal complications following an episode of disseminated intravascular coagulation.
Subject(s)
Abortion, Septic/complications , Acute Kidney Injury/etiology , Disseminated Intravascular Coagulation/diagnosis , Fibrin Fibrinogen Degradation Products , Adult , Antigens/analysis , Disseminated Intravascular Coagulation/complications , Female , Fibrin Fibrinogen Degradation Products/analysis , Humans , Platelet Adhesiveness , Pregnancy , ProtaminesABSTRACT
Platelet adhesiveness increases significantly after angiotensin II administration, in pressor and subpressor doses, only in the hypertensive patients with urinary infection. The k index on the thrombelastogram decreases significantly following angiotensin II infusion in pressor doses both in the hypertensive patients with urinary infection and in those without urinary infection. At the same time, angiotensin II infusion in pressor and subpressor doses determines a significant increase of epsilon index in both hypertensive patients with urinary infection and in those without urinary infection. These results pose the problem of thrombocyte sensitization by the urinary infection to the vasopressor substance. The increased tendency to thrombosis by angiotensin, in hypertensive patients with urinary infection, could constitute a mechanism of malignant transformation of arterial hypertension.
