Cerebral oxygenation and perfusion kinetics monitoring of military aircrew at high G using novel fNIRS wearable system.

Introduction: Real-time physiological episode (PE) detection and management in aircrew operating high-performance aircraft (HPA) is crucial for the US Military. This paper addresses the unique challenges posed by high acceleration (G-force) in HPA aircrew and explores the potential of a novel wearable functional near-infrared spectroscopy (fNIRS) system, named NIRSense Aerie, to continuously monitor cerebral oxygenation during high G-force exposure. Methods: The NIRSense Aerie system is a flight-optimized, wearable fNIRS device designed to monitor tissue oxygenation 13-20 mm below the skin's surface. The system includes an optical frontend adhered to the forehead, an electronics module behind the earcup of aircrew helmets, and a custom adhesive for secure attachment. The fNIRS optical layout incorporates near-distance, middle-distance, and far-distance infrared emitters, a photodetector, and an accelerometer for motion measurements. Data processing involves the modified Beer-Lambert law for computing relative chromophore concentration changes. A human evaluation of the NIRSense Aerie was conducted on six subjects exposed to G-forces up to +9 Gz in an Aerospace Environmental Protection Laboratory centrifuge. fNIRS data, pulse oximetry, and electrocardiography (HR) were collected to analyze cerebral and superficial tissue oxygenation kinetics during G-loading and recovery. Results: The NIRSense Aerie successfully captured cerebral deoxygenation responses during high G-force exposure, demonstrating its potential for continuous monitoring in challenging operational environments. Pulse oximetry was compromised during G-loading, emphasizing the system's advantage in uninterrupted cerebrovascular monitoring. Significant changes in oxygenation metrics were observed across G-loading levels, with distinct responses in Deoxy-Hb and Oxy-Hb concentrations. HR increased during G-loading, reflecting physiological stress and the anti-G straining maneuver. Discussion: The NIRSense Aerie shows promise for real-time monitoring of aircrew physiological responses during high G-force exposure. Despite challenges, the system provides valuable insights into cerebral oxygenation kinetics. Future developments aim for miniaturization and optimization for enhanced aircrew comfort and wearability. This technology has potential for improving anti-G straining maneuver learning and retention through real-time cerebral oxygenation feedback during centrifuge training.

Localized Multi-Site Knee Bioimpedance as a Predictor for Knee Osteoarthritis Associated Pain Within Older Adults During Free-Living.

The drastic increase in the aging population has increased the prevalence of osteoarthritis in the United States. The ability to monitor symptoms of osteoarthritis (such as pain) within a free-living environment could improve understanding of each person's experiences with this disease and provide opportunities to personalize treatments specific to each person and their experience. In this work, localized knee tissue bioimpedance and self-reports of knee pain were collected from older adults ([Formula: see text]) with and without knee osteoarthritis over 7 days of free-living to evaluate if knee tissue bioimpedance is associated with persons' knee pain experience. Within the group of persons' with knee osteoarthritis increases in 128 kHz per-length resistance and decreases in 40 kHz per-length reactance were associated with increased probability of persons having active knee pain ([Formula: see text] and [Formula: see text]).

Segmental Tissue Resistance of Healthy Young Adults during Four Hours of 6-Degree Head-Down-Tilt Positioning.

(1) Background: One effect of microgravity on the human body is fluid redistribution due to the removal of the hydrostatic gravitational gradient. These fluid shifts are expected to be the source of severe medical risks and it is critical to advance methods to monitor them in real-time. One technique to monitor fluid shifts captures the electrical impedance of segmental tissues, but limited research is available to evaluate if fluid shifts in response to microgravity are symmetrical due to the bilateral symmetry of the body. This study aims to evaluate this fluid shift symmetry. (2) Methods: Segmental tissue resistance at 10 kHz and 100 kHz was collected at 30 min intervals from the left/right arm, leg, and trunk of 12 healthy adults over 4 h of 6° head-down-tilt body positioning. (3) Results: Statistically significant increases were observed in the segmental leg resistances, first observed at 120 min and 90 min for 10 kHz and 100 kHz measurements, respectively. Median increases were approximately 11% to 12% for the 10 kHz resistance and 9% for the 100 kHz resistance. No statistically significant changes in the segmental arm or trunk resistance. Comparing the left and right segmental leg resistance, there were no statistically significant differences in the resistance changes based on the side of the body. (4) Conclusions: The fluid shifts induced by the 6° body position resulted in similar changes in both left and right body segments (that had statistically significant changes in this work). These findings support that future wearable systems to monitor microgravity-induced fluid shifts may only require monitoring of one side of body segments (reducing the hardware needed for the system).

System Performance and User Feedback Regarding Wearable Bioimpedance System for Multi-Site Knee Tissue Monitoring: Free-Living Pilot Study With Healthy Adults.

Knee-focused wearable devices have the potential to support personalized rehabilitation therapies by monitoring localized tissue alterations related to activities that reduce functional symptoms and pain. However, supporting these applications requires reported data to be reliable and accurate which can be challenging in the unsupervised free-living conditions that wearable devices are deployed. This pilot study has assessed a knee-focused wearable sensor system to quantify 1) system performance (operation, rates of data artifacts, environment impacts) to estimate realistic targets for reliable data with this system and 2) user experiences (comfort, fit, usability) to help inform future designs to increase usability and adoption of knee-focused wearables. Study data was collected from five healthy adult participants over 2 days, with 84.5 and 35.9% of artifact free data for longitudinal and transverse electrode configurations. Small to moderate positive correlations were also identified between changes in resistance, temperature, and humidity with respect to acceleration to highlight how this system can be used to explore relationships between knee tissues and environmental/activity context.

Flexible PCB Failures From Dynamic Activity and Their Impacts on Bioimpedance Measurements: A Wearable Case Study.

Wearable health monitoring systems that collect data in free-living environments are becoming increasingly popular. Flexible printed circuits provide a commercially available option that can conform to the shape of a wearable system and support electronic sensing and flexible interconnect. However, repetitive dynamic activity can stress and damage the interconnect of flexible PCBs which degrades data quality. This case study evaluated the performance of flexible PCBs providing interconnect between electrodes and sensing electronics for tissue bioimpedance measurements in a wearable system. Resistance data (1 kHz to 128 kHz) was collected from localized knee tissues of 3 participants using the wearable design with flexible PCBs over 7 days of free-living. From electrical and optical inspection after use trace cracking of the flexible PCBs occurred, degrading tissue resistances reported by the wearable system. Exploration of these results advances understanding of how flexible PCBs perform in free-living conditions for wearable bioimpedance applications.

Short-Term Segmental Bioimpedance Alterations During 6° Head-Down Tilt.

As missions in space increase in duration and distance from Earth it is critical to understand the impact that exposure to microgravity has on the health and potential performance of crews. Segmental bioimpedance measurements can track resistances changes in tissues that result from fluid redistribution and could be a tool for continuous fluid shift monitoring in microgravity. In this work, the range of segmental (legs, arms, torso, and neck) 10 kHz and 100 kHz resistances and their relative changes during 4 hours of 6° head down tilt are reported as well as the observed resistance differences between left/right body segments throughout the protocol.

Localized Bioimpedance Measurements with the MAX3000x Integrated Circuit: Characterization and Demonstration.

The commercial availability of integrated circuits with bioimpedance sensing functionality is advancing the opportunity for practical wearable systems that monitor the electrical impedance properties of tissues to identify physiological features in support of health-focused applications. This technical note characterizes the performance of the MAX3000x (resistance/reactance accuracy, power modes, filtering, gains) and is available for on-board processing (electrode detection) for localized bioimpedance measurements. Measurements of discrete impedances that are representative of localized tissue bioimpedance support that this IC has a relative error of <10% for the resistance component of complex impedance measurements, but can also measure relative alterations in the 250 mΩ range. The application of the MAX3000x for monitoring localized bicep tissues during activity is presented to highlight its functionality, as well as its limitations, for multi-frequency measurements. This device is a very-small-form-factor single-chip solution for measuring multi-frequency bioimpedance with significant on-board processing with potential for wearable applications.

Threshold and Trend Artifacts in Localized Multi-Frequency Bioimpedance Measurements.

Localized tissue bioimpedance is being widely investigated as a technique to identify physiological features in support of health focused applications. In support of this method being translated into wearable systems for continuous monitoring, it is critical to not only collect measurements but also evaluate their quality. This is necessary to reduce errors in equipment or measurement conditions from contributing data artifacts to datasets that will be analyzed. Two methods for artifact identification in resistance measurements of bioimpedance datasets are presented. These methods, based on thresholding and trend detection, are applied to localized knee bioimpedance datasets collected from two knee sites over 7 consecutive days in free-living conditions. Threshold artifacts were identified in 0.04% (longitudinal and transverse) and 0.69% (longitudinal) /3.50% (transverse) of the total data collected.