ABSTRACT
OBJECTIVE: Oral supplementation with curcumin demonstrated a beneficial effect on some ocular diseases, including uveitis and macular edema. This study aimed to evaluate the effectiveness and safety of a curcumin formulation with the hydrophilic carrier (CHC; Diabec®, Alfa Intes, Italy) as an adjuvant to standard steroid treatment in adults suffering from acute non-infectious uveitic macular edema (NIUME). PATIENTS AND METHODS: This was a monocenter prospective observational study carried out between January 2019 and May 2020 on consecutive patients with a new diagnosis of NIUME. Patients were treated with standard therapy or with a CHC add-on to standard treatment. The observation period for each patient was 12 months. The Best Corrected Visual Acuity (BCVA) and the Central Macular Thickness (CMT) were the primary outcomes; Foveal Avascular Zone (FAZ) and intraocular pressure (IOP) were also assessed, along with safety data. RESULTS: A total of 43 eyes of 26 patients were analyzed. CHC-treated eyes showed an improvement in mean BCVA from baseline (0.34 logMar) to T6 (0.20 logMar) and T12 (0.19 logMar; p≤0.05 and p≤0.01, respectively); CMT decreased from a mean of 320 µm (T0) to 278 µm (T6; p≤0.05) and 272 µm (T12; p≤0.01). A significant improvement of mean BCVA in the CHC group at T6 and T12 was reported compared to the control group (p≤0.01). FAZ and IOP showed no statistically significant variations in both groups. No adverse events were recorded. CONCLUSIONS: CHC as an adjuvant treatment improved the anatomical and functional outcomes, without significant side effects in eyes affected by the recent onset of NIUME, compared to the sole standard therapy.
Subject(s)
Curcumin , Macular Edema , Uveitis , Adult , Curcumin/therapeutic use , Glucocorticoids/therapeutic use , Humans , Intravitreal Injections , Macular Edema/drug therapy , Tomography, Optical Coherence , Treatment Outcome , Uveitis/diagnosis , Uveitis/drug therapy , Visual AcuityABSTRACT
This longitudinal study aimed to elucidate whether systemic bone fragility predicts severe periodontal clinical attachment loss (CAL) and tooth loss over the years and to test the influence of bone medication and periodontal maintenance in these relationships. Elderly women were evaluated for bone mineral density (BMD) and for fracture risk assessment (FRAX) in a cross-sectional analysis and retrospective follow-up (6- and 10-y periods). Data on BMD and FRAX were used as indicators of bone fragility in structural equation modeling. Periodontal examination and data on postmenopausal tooth loss were recorded. Multivariate Poisson regression models with robust covariance were used to estimate relative risk (RR) and 95% CI of BMD and FRAX for sites with CAL ≥6 mm and for tooth loss. The cross-sectional analysis included 134 women aged 65 to 80 y, and from them 71 and 49 women had available data for analysis in the 6- and 10-y follow-up periods, respectively. Bone fragility predicted severe CAL over 10 y (e.g., femoral neck: 10-y analysis, ß = -0.389, P = 0.005; cross-sectional, ß = -0.190, P = 0.004); however, this association did not remain significant when the use of bone medication was evaluated. Poisson regression showed that a better skeletal condition was associated with a lower risk of severe periodontal disease and tooth loss (cross-sectional femoral neck: RR = 0.08, P < 0.001; RR = 0.03, P < 0.001, respectively) when not adjusted for bone medication and periodontal maintenance. The receiver operating characteristic curve suggested that women with osteoporosis should be referred for periodontal assessment (sensitivity = 71.0%, specificity = 70.0%). Bone fragility is a relevant longitudinal predictor of severe periodontal disease and tooth loss among elderly women. The use of bisphosphonates improved the bone condition as well as the periodontal status. Periodontal maintenance also minimized the negative impact of low BMD on teeth-supportive tissues in the studied population. Knowledge Transfer Statement: The results of this study present evidence that the management of bone fragility and osteoporosis may be important in the prevention of periodontal attachment loss and future tooth loss. Besides the antiresorptive effects of the antiosteoporosis drugs on systemic bone conditions, these medications may protect periodontal tissues. The interaction of health care professionals such as dentists and physicians represents a key role for the approach to women's health, especially in an aging world.
Subject(s)
Bone Density Conservation Agents , Periodontal Diseases , Tooth Loss , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Humans , Longitudinal Studies , Retrospective StudiesABSTRACT
The aim of the present study is to investigate the correlation between microbial activity, i.e., biological stability measured by aerobic (OD(20) test) and anaerobic tests (ABP test), and odour emissions of organic fraction of municipal solid waste during anaerobic digestion in a full-scale treatment plant considering the three stages of the process (input, digested and post-digested waste). The results obtained indicated that the stabilization of the treated material reduces the odour impact measured by the olfactometric approach. Successive application of gas chromatography mass spectrometry (GC-MS) and electronic nose (EN) allowed the characterization of the different groups of volatile organic compounds (VOCs) responsible of odour impacts determining, also, their concentration. Principal component and partial least squares analyses applied to the EN and GC-MS data sets gave good regression for the OD(20) vs the EN and OD(20) vs the GC-MS data. Therefore, OD(20) reduction could be used as an odour depletion indicator.
ABSTRACT
The aim of the present study is to investigate the correlation between microbial activity, i.e., biological stability measured by aerobic (OD20 test) and anaerobic tests (ABP test), and odour emissions of organic fraction of municipal solid waste during anaerobic digestion in a full-scale treatment plant considering the three stages of the process (input, digested and post-digested waste). The results obtained indicated that the stabilization of the treated material reduces the odour impact measured by the olfactometric approach. Successive application of gas chromatography mass spectrometry (GC-MS) and electronic nose (EN) allowed the characterization of the different groups of volatile organic compounds (VOCs) responsible of odour impacts determining, also, their concentration. Principal component and partial least squares analyses applied to the EN and GC-MS data sets gave good regression for the OD20 vs the EN and OD20 vs the GC-MS data. Therefore, OD20 reduction could be used as an odour depletion indicator.
Subject(s)
Cities , Odorants/analysis , Organic Chemicals/analysis , Refuse Disposal/methods , Anaerobiosis , Gas Chromatography-Mass Spectrometry , Italy , Principal Component Analysis , Volatile Organic Compounds/analysisSubject(s)
Breast Neoplasms/blood , Breast Neoplasms/pathology , Hypercalcemia/etiology , Proteins/analysis , Aged , Breast Neoplasms/complications , Breast Neoplasms/therapy , Cyclic AMP/urine , Female , Humans , Hypercalcemia/blood , Hypercalcemia/therapy , Mastectomy, Radical , Neoplasm Metastasis , Parathyroid Hormone/blood , Parathyroid Hormone-Related Protein , Tamoxifen/therapeutic useABSTRACT
The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). Twenty patients (11 females), suffering from minor RAU, participated in this study during a period of 15 weeks. The patients brushed their teeth twice a day with the toothpaste. They were examined once a week to monitor the number and size of ulcers. The mean number of ulcers in both groups was about 40% lower than that found before treatment. Ulcer mean diameter had also decreased in both the placebo (about 32%) and experimental groups (about 66%). There were no statistically significant differences between the two groups in number of weeks with ulcers, in total number of ulcers per patient, and in mean diameter of the ulcers. In conclusion, no significant differences in therapeutic effects could be shown between treatments with Z and P.
Subject(s)
Glucan 1,4-alpha-Glucosidase/therapeutic use , Glucose Oxidase/therapeutic use , Stomatitis, Aphthous/drug therapy , Toothpastes/therapeutic use , Adolescent , Adult , Child , Double-Blind Method , Female , Humans , Male , Middle Aged , Toothpastes/chemistry , Treatment OutcomeABSTRACT
The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). Twenty patients (11 females), suffering from minor RAU, participated in this study during a period of 15 weeks. The patients brushed their teeth twice a day with the toothpaste. They were examined once a week to monitor the number and size of ulcers. The mean number of ulcers in both groups was about 40
lower than that found before treatment. Ulcer mean diameter had also decreased in both the placebo (about 32
) and experimental groups (about 66
). There were no statistically significant differences between the two groups in number of weeks with ulcers, in total number of ulcers per patient, and in mean diameter of the ulcers. In conclusion, no significant differences in therapeutic effects could be shown between treatments with Z and P.
ABSTRACT
The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). Twenty patients (11 females), suffering from minor RAU, participated in this study during a period of 15 weeks. The patients brushed their teeth twice a day with the toothpaste. They were examined once a week to monitor the number and size of ulcers. The mean number of ulcers in both groups was about 40
lower than that found before treatment. Ulcer mean diameter had also decreased in both the placebo (about 32
) and experimental groups (about 66
). There were no statistically significant differences between the two groups in number of weeks with ulcers, in total number of ulcers per patient, and in mean diameter of the ulcers. In conclusion, no significant differences in therapeutic effects could be shown between treatments with Z and P.
ABSTRACT
To compare, in vitro, the seal of Ti-Flex and GP cone obturations, to verify the adaptation of the Ti-Flex cone inside the obturated canal and to evaluate the density of the sealer material, eighty-two canals of freshly extracted teeth were manually prepared and obturated with corresponding Ti-Flex cones and with single GP cones. After dye infiltration the roots were transversally sectioned. On the first 5 apical sections (i.e. 3-5 mm from apex), the Ti-Flex obturations presented significantly more leakage than the GP obturations since no cones but only the sealer obturated these sections. The Ti-Flex cones appeared adapted to the walls in the apical and median segments of the canals. The density of the sealer in the Ti-Flex obturations was judged satisfactory in most of the specimens. The seal and adaptation defects of the Ti-Flex demonstrated in this study could be balanced by the limited effect of straightening the canal and thinning its dentinal wall of this anchoring system.
Subject(s)
Root Canal Obturation/instrumentation , Evaluation Studies as Topic , Gutta-Percha , Humans , In Vitro Techniques , Materials Testing , Root Canal Obturation/methods , TitaniumABSTRACT
The prevalence of grooved tongue, geographic tongue, and ankyloglossia, was investigated in 660 children, 3 to 13 years old, which attended the Out patient Clinic of the University Hospital of Buenos Aires for unrelated complaints. The figures obtained are at variance--by far--from those published by other people engaged in the same line of research. Probably, further studies with a much larger amount of patients are called for.
Subject(s)
Tongue Diseases/epidemiology , Adolescent , Argentina/epidemiology , Child , Child, Preschool , Female , Glossitis, Benign Migratory/epidemiology , Humans , Lingual Frenum/abnormalities , Male , Tongue, Fissured/epidemiologyABSTRACT
In this study the relative frequency of oral lesions was evaluated in a group of 526 patients, 55 years old or elder. Clinical and pathological data were obtained from 244 patients who attended to a clinic of Medical and Social Assistance Program (PAMI) ad from 282 cases registered in the files of the Surgical Pathology Laboratory F.O.U.B.A. (LAP) since 1984 to 1986. The mean age of the groups was 63 years old. The most frequency lesions were the pseudotumors (44.6%) in LAP and (17.2%) in PAMI; premalignant lesions were (20.5%) in LAP, while in PAMI (2.4%). The cysts in LAP found (15.6%) in PAMI were (2.4%). The groups of PAMI showed (90%) of Candidiasis. Traumatic ulcer (30.7%) and afthae (28.8%). In LAP were (4.6%) the traumatic ulcer. The malignant tumors the most frequency was carcinoma espinocelular (8.16%) LAP and (6.56%) PAMI. It was remarkable that stomatodine as represented in PAMI (72.2%) and Candidiasis were (90%). Candidiasis were 90% of the specific inflammations. Results suggest that oral mobility in elderly patients correlates with the findings in this type of social assisted groups. The figures of the importance of methodical collaboration of Stomatologists and Oral Pathologists for differential diagnosis.
Subject(s)
Dental Care for Aged , Mouth Diseases/epidemiology , Mouth Neoplasms/epidemiology , Aged , Argentina/epidemiology , Candidiasis, Oral/epidemiology , Cysts/epidemiology , Female , Humans , Male , Middle Aged , Stomatitis, Denture/epidemiologyABSTRACT
In this study the relative frequency of oral lesions was evaluated in a group of 526 patients, 55 years old or elder. Clinical and pathological data were obtained from 244 patients who attended to a clinic of Medical and Social Assistance Program (PAMI) ad from 282 cases registered in the files of the Surgical Pathology Laboratory F.O.U.B.A. (LAP) since 1984 to 1986. The mean age of the groups was 63 years old. The most frequency lesions were the pseudotumors (44.6
) in LAP and (17.2
) in PAMI; premalignant lesions were (20.5
) in LAP, while in PAMI (2.4
). The cysts in LAP found (15.6
) in PAMI were (2.4
). The groups of PAMI showed (90
) of Candidiasis. Traumatic ulcer (30.7
) and afthae (28.8
). In LAP were (4.6
) the traumatic ulcer. The malignant tumors the most frequency was carcinoma espinocelular (8.16
) LAP and (6.56
) PAMI. It was remarkable that stomatodine as represented in PAMI (72.2
) and Candidiasis were (90
). Candidiasis were 90
of the specific inflammations. Results suggest that oral mobility in elderly patients correlates with the findings in this type of social assisted groups. The figures of the importance of methodical collaboration of Stomatologists and Oral Pathologists for differential diagnosis.
ABSTRACT
The prevalence of grooved tongue, geographic tongue, and ankyloglossia, was investigated in 660 children, 3 to 13 years old, which attended the Out patient Clinic of the University Hospital of Buenos Aires for unrelated complaints. The figures obtained are at variance--by far--from those published by other people engaged in the same line of research. Probably, further studies with a much larger amount of patients are called for.
ABSTRACT
In this study the relative frequency of oral lesions was evaluated in a group of 526 patients, 55 years old or elder. Clinical and pathological data were obtained from 244 patients who attended to a clinic of Medical and Social Assistance Program (PAMI) ad from 282 cases registered in the files of the Surgical Pathology Laboratory F.O.U.B.A. (LAP) since 1984 to 1986. The mean age of the groups was 63 years old. The most frequency lesions were the pseudotumors (44.6
) in LAP and (17.2
) in PAMI; premalignant lesions were (20.5
) in LAP, while in PAMI (2.4
). The cysts in LAP found (15.6
) in PAMI were (2.4
). The groups of PAMI showed (90
) of Candidiasis. Traumatic ulcer (30.7
) and afthae (28.8
) the traumatic ulcer. The malignant tumors the most frequency was carcinoma espinocelular (8.16
) LAP and (6.56
) PAMI. It was remarkable that stomatodine as represented in PAMI (72.2
) and Candidiasis were (90
of the specific inflammations. Results suggest that oral mobility in elderly patients correlates with the findings in this type of social assisted groups. The figures of the importance of methodical collaboration of Stomatologists and Oral Pathologists for differential diagnosis.
ABSTRACT
The prevalence of grooved tongue, geographic tongue, and ankyloglossia, was investigated in 660 children, 3 to 13 years old, which attended the Out patient Clinic of the University Hospital of Buenos Aires for unrelated complaints. The figures obtained are at variance--by far--from those published by other people engaged in the same line of research. Probably, further studies with a much larger amount of patients are called for.
ABSTRACT
The aim of this survey was to determine the prevalence of oral mucosa lesions in children aged 4-13 yr from two schools, one (S1) having a higher socioeconomic status than the other (S2). In all, 846 children were examined, 463 from S1 and 383 from S2, of whom 555 were boys and 291 were girls. There were 359 boys and 104 girls in S1; 196 boys and 187 girls in S2. Fifteen different lesion types were discerned. The most frequent ones were recurrent aphthous ulceration (RAU) (92 cases); fissured cheilitis (54); herpes labialis (44); angular cheilitis (30); geographic tongue (25); smooth tongue (22); and plicated tongue (17). An outstanding finding was the contrasting distribution of certain lesion types in the two schools. RAU was observed in 19% of the children from S1, making up 50% of all lesions detected. However, in S2 only 2% exhibited RAU, making up less than 4% of observed lesions. On the other hand, herpes labialis was seen in 1% of S1 and 10% of S2 children, regardless of age or sex. Plicated tongue was found in 3.2% in S1 and 0.5% in S2; fissured cheilitis in 2.9% in S1 and 12.8% in S2; and angular cheilitis in 1.1% in S1 and 6.5% in S2. Therefore, there were no statistical differences between the schools in the ratio of total lesions observed to children examined, but a significant difference was apparent when individual lesions were taken into account.