1.
J Pediatr
; 147(1): 106-8, 2005 Jul.
Article
in English
| MEDLINE
| ID: mdl-16027706
ABSTRACT
Hurler syndrome is a lysosomal storage disease resulting in fatal cardiac or neurologic sequelae unless alpha-iduronidase production is reconstituted with hematopoietic stem cell transplantation. We report on a 4-year, 6-month-old boy with mixed donor chimerism and low enzyme levels but a normal neurodevelopmental trajectory.
Subject(s)
Bone Marrow Transplantation , Developmental Disabilities/prevention & control , Iduronidase/blood , Mucopolysaccharidosis I/therapy , Transplantation Chimera , Humans , Infant , Male , Treatment Outcome
2.
J Clin Microbiol
; 43(3): 1462-4, 2005 Mar.
Article
in English
| MEDLINE
| ID: mdl-15750134
ABSTRACT
Adenovirus causes disseminated disease following bone marrow transplantation (BMT). We report a child who underwent T-cell-depleted BMT. Adenovirus subgenus F serotype 41 was detected antemortem by PCR in cerebrospinal fluid and postmortem in other tissues. Serotypes 40 and 41, associated with gastrointestinal disease, have not previously been implicated in disseminated disease.