ABSTRACT
Four normal male volunteers participated in a study designed to examine the disposition of gold given intramuscularly as gold sodium thiomalate. Blood samples were collected for 32 days following the administration of 10 mg of gold sodium thiomalate. Plasma gold concentrations were determined by atomic absorption spectrometry. A triphasic decay pattern in plasma gold concentrations was observed. Terminal log-linear phases corresponded to a mean disposition half-life of 25 days. Apparent total body clearance of gold was 7.0 +/- 0.6 ml kg-1 day-1 and the apparent volume of distribution was 0.26 +/- 0.051 kg-1. These pharmacokinetic data are in contrast to previous data from other investigators who have reported half-lives of approximately 5 days. Data from the current study provide a sound rationale for the currently used empiric dosing regimens.
Subject(s)
Gold Sodium Thiomalate/metabolism , Adult , Gold/metabolism , Gold Sodium Thiomalate/administration & dosage , Half-Life , Humans , Injections, Intramuscular , Kinetics , Male , Spectrophotometry, AtomicABSTRACT
Two normal males participated in a study designed to examine the disposition of gold given intravenously and intramuscularly as gold sodium thiomalate. Blood samples were collected for 30 days, urine and feces for ten. A triphasic decay pattern in plasma gold concentrations was observed. Terminal log-linear phases corresponded to a mean disposition half-life of 12.5 days. Absolute bioavailability of IM gold sodium thiomalate appears to be variable with one subject having complete absorption and the other absorbing 64% of the administered IM dose. The major route of elimination of an IV dose of gold sodium thiomalate is urinary excretion, with a mean of 35% of the dose found in the urine in ten days. Fecal elimination accounts for an additional 9.4% of the IV dose excreted in ten days, probably as a result of biliary secretion.
Subject(s)
Gold Sodium Thiomalate/metabolism , Adult , Feces/analysis , Gold/blood , Gold/urine , Humans , Injections, Intramuscular , Injections, Intravenous , Kinetics , Male , Neutron Activation Analysis , Time FactorsSubject(s)
Gold Sodium Thiomalate/pharmacology , Gold Sodium Thiomalate/blood , Half-Life , Humans , Injections, Intramuscular , Kinetics , MaleABSTRACT
A review of the clinical features of seven patients with sporotrichosis arthritis showed that six had joint infection without previous skin or lung involvement and that one with myelofibrosis had joint and skin infection. The average time from onset of joint symptoms to diagnosis was 25 months, resulting in joint damage that required arthrodesis in four patients. Tissue from open synovial biopsy was superior to synovial fluid for obtaining a positive culture; concomitant synovial fluid and synovial tissue cultures were superior to either one alone. Granulomatous inflammation was seen in synovial tissue in six patients biopsied. Amphotericin B with surgical debridement of the affected joint was successful treatment in four patients. Although an uncommon cause of joint disease, sporotrichosis arthritis may go unrecognized and mimic other forms of arthritis, resulting in irreparable damage in an otherwise curable form of arthritis.
Subject(s)
Arthritis, Infectious/diagnosis , Sporotrichosis/complications , Adult , Aged , Arthritis, Infectious/etiology , Arthritis, Infectious/pathology , Arthritis, Infectious/therapy , Female , Humans , Male , Middle AgedABSTRACT
Synovial fluid lymphocytes and synovial fluid from most patients with rheumatoid arthritis induced blastogenesis of autologous peripheral blood lymphocytes. In vitro transfer of the mitogenic activity of the synovial fluid to peripheral blood lymphocytes was not accomplished, but diminished response of the peripheral blood lymphocytes to phytohemagglutinin stimulation after incubation in synovial fluid was demonstrated. These findings suggest that a similar blastogenic response in vivo may induce the lymphoid hyperplasia regularly observed in rheumatoid arthritis.
Subject(s)
Arthritis, Rheumatoid/immunology , Lymphocyte Activation , Lymphocytes/immunology , Synovial Fluid/immunology , Arthritis, Reactive/immunology , Autoantigens/analysis , Chondrocalcinosis/immunology , DNA/biosynthesis , Dose-Response Relationship, Drug , Gout , Humans , Lectins/pharmacology , Lymphocyte Activation/drug effects , Lymphocytes/metabolism , Osteoarthritis/immunologyABSTRACT
To learn whether in vitro blastogenesis of lymphocytes is affected by in vivo salicylate ingestion, blood samples were obtained from 19 normal volunteers before and after therapeutic doses of aspirin. Lymphocyte transformation studies performed on these blood samples showed marked and statistically significant suppression of blastogenesis. Maximum suppression was observed in blood samples obtained 12 hours after the last aspirin ingestion. As compared to controls, samples obtained at this time showed mean blastogenic responses to phytohemagglutinin and pokeweed mitogens of 49 and 56 per cent respectively. No correlation could be demonstrated between the plasma salicylic acid level and the degree of suppression of blastogenesis. Aspirin ingestion altered neither the proportions of circulating T and B cells nor the viability of lymphocytes in culture.
