1.
Bioorg Med Chem Lett
; 16(3): 641-4, 2006 Feb.
Article
in English
| MEDLINE
| ID: mdl-16263281
ABSTRACT
We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the beta-secretase inhibitor 7m which has an in vitro IC(50)=35 nM. The synthesis and biological activities of these compounds are described.
