1.
Acta Physiol Scand
; 181(4): 561-70, 2004 Aug.
Article
in English
| MEDLINE
| ID: mdl-15283771
ABSTRACT
The renin-angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RAS are triggered via the type 1 (AT(1)) class of angiotensin receptors. Pharmacological blockade of the AT(1) receptor lowers blood pressure and slows the progression of cardiovascular and renal diseases. Gene-targeting technology provides an experimental approach for precisely dissecting the physiological functions of the RAS. Here, we review how gene-targeting experiments have elucidated AT(1) receptor functions.
Subject(s)
Receptor, Angiotensin, Type 1/physiology , Renin-Angiotensin System/physiology , Animals , Blood Pressure/physiology , Disease Models, Animal , Gene Targeting , Humans , Hypertension/physiopathology , Kidney/physiology , Mice , Mice, Transgenic , Receptor, Angiotensin, Type 1/genetics
2.
Ann N Y Acad Sci
; 772: 152-63, 1995 Nov 27.
Article
in English
| MEDLINE
| ID: mdl-8546388