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1.
Clin Otolaryngol ; 34(5): 460-6, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19793279

ABSTRACT

OBJECTIVES: Optical coherence tomography, an imaging modality using near-infrared light, produces cross-sectional tissue images with a lateral pixel resolution of 10 microm. However, normative data is first needed on epithelial thickness for lesion characterisation, and, to date, little exists. The purpose of our study is to measure normal laryngeal epithelial thickness by in vivo optical coherence tomography, and compare these values to those obtained from fixed ex-vivo laryngectomy specimens. DESIGN AND SETTING: Prospective at a single medical center in California, United States. PARTICIPANTS: A total of 116 patients undergoing operative endoscopy. MAIN OUTCOME MEASURES: Optical coherence tomography images of clinically normal laryngeal subsites were selected. Calibrated measurements of epithelial thickness at various laryngeal subsites were recorded. Measurements of epithelial thickness from corresponding areas were obtained using optical micrometry on histologically normal regions of 15 total laryngectomy specimens. Descriptive statistics were performed. RESULTS: Mean epithelial optical coherence tomography thicknesses were: true vocal cords (81 microm), false vocal cords (78 microm), subglottis (61 microm), aryepiglottic folds (111 microm), laryngeal epiglottis (116 microm) and lingual epiglottis (170 microm). Epithelial thicknesses in fixed tissues were: true vocal cords (103 microm), false vocal cords (79 microm), aryepiglottic folds (205 microm) subglottis (61 microm), laryngeal epiglottis (38 microm) and lingual epiglottis (130 microm). CONCLUSIONS: Optical coherence tomography does not have the artifacts associated with conventional histologic techniques. The inevitable development of office-based optical coherence tomography devices will increase the precision of laryngeal measurements and contribute to the clinical application of this technology in diagnosing laryngeal disease.


Subject(s)
Laryngeal Neoplasms/pathology , Larynx/pathology , Aged , Female , Humans , Laryngeal Neoplasms/surgery , Laryngectomy , Laryngoscopy , Larynx/surgery , Male , Middle Aged , Tomography, Optical Coherence
2.
Arch Otolaryngol Head Neck Surg ; 126(7): 857-64, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10888998

ABSTRACT

BACKGROUND: In companion studies on canine and rodent laryngeal muscle, we observed that (1) muscle fibers in both the canine and rodent posterior cricoarytenoid (PCA) muscles have a slower myosin heavy-chain (MyHC) isoform profile than those in the thyroarytenoid (TA) muscle; (2) the muscle fiber composition of PCA and TA muscles in canines and rodents is complex given the presence of so-called hybrid fibers (fibers coexpressing various combinations of MyHC isoforms); (3) the types and proportions of hybrid fibers are both muscle specific and, in some cases, region specific; and (4) the MyHC isoform profile of canine laryngeal muscle appears to be slower than that of rodent laryngeal muscle, suggesting the possibility that larger mammals have a slower MyHC isoform profile. OBJECTIVES: Given the findings of these companion studies and the fact that very little is known about the MyHC isoform composition of laryngeal muscle fibers, the primary objectives of this study were to determine (1) the types of MyHC isoforms found in the human PCA and TA muscles, (2) if there were regional differences in MyHC isoform composition, (3) if hybrid fibers commonly occur in human laryngeal muscle, and (4) if the MyHC isoform profile of human laryngeal muscle is slower than that of canine and rodent laryngeal muscle. RESULTS AND CONCLUSIONS: The findings of this study clearly demonstrate that both the PCA and TA muscles in humans express 3 types of MyHC isoforms (ie, slow type I, fast type IIA, and fast type IIX MyHC isoforms). At the single-fiber level, there were distinct regional differences and hybrid fibers were a common occurrence. Finally, the data demonstrate that the PCA and TA muscles of humans have a slower MyHC profile than that found in either canine or rodent laryngeal muscle.


Subject(s)
Laryngeal Muscles/cytology , Aged , Animals , Dogs , Humans , Middle Aged , Muscle Fibers, Skeletal , Myosin Heavy Chains/analysis , Rodentia , Species Specificity
3.
Arch Otolaryngol Head Neck Surg ; 126(7): 865-73, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10888999

ABSTRACT

BACKGROUND: The canine lateral cricoarytenoid muscle contains a large proportion of muscle fibers that coexpress various combinations of myosin heavy-chain isoforms (ie, so-called hybrid fibers). OBJECTIVE: To test the hypothesis that hybrid fibers are a common motif throughout laryngeal muscles. DESIGN: The posterior cricoarytenoid, canine cricothyroid, and thyroarytenoid muscles were removed from 5 beagle dogs. The posterior cricoarytenoid and canine cricothyroid muscles were each dissected into horizontal, oblique, and rectus regions. The thyroarytenoid was separated into medial and lateral regions. Approximately 40 single fibers were microdissected from each region ( approximately 1800 total fibers were sampled) and placed into a denaturing sample buffer. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis was then used to separate the individual myosin heavy-chain isoforms. RESULTS: Each laryngeal muscle contained hybrid fibers; however, the types and proportions of hybrid fibers were clearly muscle specific. Within a given muscle, there were relatively minor regional differences in the types and proportions of hybrid fibers. CONCLUSION: If the myosin heavy-chain isoform composition of a single fiber can be used as a "physiological marker," then the extent of hybridism may reveal the diversity of activity required of a given laryngeal muscle.


Subject(s)
Laryngeal Muscles/cytology , Muscle Fibers, Skeletal/chemistry , Myosin Heavy Chains/analysis , Animals , Dogs , Laryngeal Muscles/chemistry
4.
Arch Otolaryngol Head Neck Surg ; 126(7): 874-80, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10889000

ABSTRACT

BACKGROUND: Studies have shown that canine laryngeal muscle contains a large number of muscle fibers that coexpress varying combinations of myosin heavy-chain (MyHC) isoforms. Currently, it is not clear whether this phenomenon is unique to canine laryngeal muscle or occurs in all mammals. OBJECTIVES: To examine the single-fiber MyHC isoform composition of rodent laryngeal muscle and to examine the plasticity of single-fiber MyHC isoform composition via manipulation of thyroid state. RESULTS: (1) Findings of single-fiber electrophoretic analyses clearly demonstrate that most fibers in both the posterior cricoarytenoid and thyroarytenoid muscles exhibit MyHC polymorphism. However, the proportions and patterns of polymorphism appear to be muscle specific. (2) Although the fast type IIL isoform was observed in fibers from both muscles, it was always coexpressed in combination with other MyHC isoforms (ie, no pure type IIL fibers were found), and always represented a minor proportion of the total MyHC pool. (3) Altering the thyroid state proved a useful tool for exploring the scope of MyHC isoform expression in these muscles. While the posterior cricoarytenoid muscle seemed more sensitive to the thyroid state, transitions in both muscles were primarily confined to the fast type IIX and IIB MyHC isoforms. CONCLUSION: The findings of this study support the concept that single-fiber MyHC polymorphism occurs commonly in mammalian laryngeal muscle.


Subject(s)
Laryngeal Muscles/chemistry , Laryngeal Muscles/cytology , Myosin Heavy Chains/analysis , Thyroid Hormones/physiology , Animals , Electrophoresis , Female , Polymorphism, Genetic , Rats , Rats, Sprague-Dawley , Species Specificity , Triiodothyronine/physiology
5.
Ann Otol Rhinol Laryngol ; 109(4): 365-71, 2000 Apr.
Article in English | MEDLINE | ID: mdl-10778890

ABSTRACT

First described in 1982, laryngeal synkinesis continues to play an important diagnostic and therapeutic role following recurrent laryngeal nerve (RLN) injury. Vocal fold motion impairment (formerly called "vocal cord paralysis"), hyperadducted and hyperabducted vocal folds, and certain laryngeal spasmodic and tremor disorders are often best explained by synkinesis. A closer look at these mechanisms confirms that following RLN injury, immobile vocal folds may be nearly normally functional (favorable), or spastic, hyperadducted, or hyperabducted (unfavorable). This has resulted in a functional classification of laryngeal synkinesis as follows: type I laryngeal synkinesis, with satisfactory voice and airway (vocal fold poorly mobile, or immobile); type II synkinesis, with spasmodic vocal folds and an unsatisfactory voice and/or airway; type III synkinesis, with hyperadducted vocal folds and airway compromise; and type IV synkinesis, with hyperabducted vocal folds, poor voice, and possible aspiration. This classification facilitates the understanding of laryngeal pathophysiology following RLN injuries and promotes a more scientific basis for management.


Subject(s)
Laryngeal Muscles/physiopathology , Recurrent Laryngeal Nerve Injuries , Vocal Cord Paralysis/physiopathology , Adult , Female , Humans , Male , Middle Aged , Recurrent Laryngeal Nerve/physiopathology , Vocal Cord Paralysis/classification , Vocal Cord Paralysis/etiology
6.
J Craniomaxillofac Trauma ; 5(4): 15-24, 1999.
Article in English | MEDLINE | ID: mdl-11951261

ABSTRACT

BACKGROUND AND OBJECTIVES: Ocular injuries occur commonly in patients with facial trauma. Patients with significant eye injuries may present with grossly normal eyes and good visual acuity; however, subsequent ocular disorders may become apparent. The estimates of incidence vary considerably. Trauma is the second leading cause of blindness, and a review is, therefore, warranted. METHODS AND MATERIALS: Several extensive studies are reviewed. Blunt and penetrating trauma are examined by their respective subdivisions. The initial assessment and ophthalmologic examination of patients with facial trauma are discussed, and the type of injury that may occur secondary to trauma is delineated. Management is reviewed and discussed, including a recently developed diagnostic scoring system. Three clinical cases illustrate the procedure. RESULTS AND/OR CONCLUSIONS: The diagnosis of ocular injuries resulting from trauma is difficult. The recently introduced scoring system was found to improve the procedure. Based on this system, the authors have devised an algorithm to assist the clinician, with emphasis on visual acuity and the importance of visual examination.


Subject(s)
Eye Injuries/diagnosis , Facial Injuries/complications , Orbital Fractures/complications , Adult , Algorithms , Blindness/etiology , Child , Eye Hemorrhage/diagnosis , Eye Injuries/classification , Eye Injuries/complications , Eye Injuries, Penetrating/classification , Eyelids/injuries , Female , Humans , Hyphema/diagnosis , Lacerations/diagnosis , Male , Middle Aged , Optic Nerve Diseases/diagnosis , Retinal Detachment/diagnosis , Retrobulbar Hemorrhage/diagnosis , Visual Acuity , Vitreous Hemorrhage/diagnosis , Wounds, Nonpenetrating/classification
7.
Plast Reconstr Surg ; 102(2): 430-6; discussion 437-8, 1998 Aug.
Article in English | MEDLINE | ID: mdl-9703080

ABSTRACT

Differences in regeneration of sensory and motor nerves were studied in rats to determine the effects of entubulation with collagen conduits. The rat sciatic nerve was repaired either with a 10-mm saline-filled gap or with a no-gap end-to-end repair cuffed within collagen tubules. These repairs were compared with the standard epineurial repairs. The populations of regenerated motor and sensory neurons in the peroneal nerves of all repairs were compared against the populations of normal peroneal neurons using horseradish peroxidase retrograde labeling. The epineurial repair resulted in regeneration of 65 percent (409 +/- 150) of motor neurons and 79 percent (2127 +/- 516) of sensory neurons (n = 6). The no-gap end-to-end repair in a collagen tubule resulted in regeneration of 53 percent (338 +/- 203) of motor and 70 percent (1893 +/- 794) of sensory neurons (n = 7). In the 10-mm gap repair, only 6.2 percent (39 +/- 18) of motor neurons but 63 percent (1710 +/- 557) of sensory neurons regenerated (n = 5). These results show that collagen entubulation supports nerve regeneration in end-to-end nerve repairs comparably to standard epineurial suture repairs. With the 10-mm gap repairs in collagen tubules, sensory neurons regenerated consistently better than motor neurons in the same environment. Therefore, intrinsic differences exist between motor and sensory neuron regeneration in the same nerve.


Subject(s)
Collagen , Microsurgery/methods , Motor Neurons/physiology , Nerve Regeneration/physiology , Sensory Receptor Cells/physiology , Anastomosis, Surgical/methods , Animals , Female , Motor Neurons/ultrastructure , Rats , Rats, Sprague-Dawley , Sciatic Nerve/pathology , Sciatic Nerve/physiology , Sensory Receptor Cells/ultrastructure , Suture Techniques
8.
Arch Otolaryngol Head Neck Surg ; 124(3): 335-8, 1998 Mar.
Article in English | MEDLINE | ID: mdl-9525521

ABSTRACT

Reconstruction of the microtic auricle is a difficult process requiring considerable experience and dedication to detail. It is a multistage proposition requiring the talents of both the reconstructive surgeon and the otologic surgeon. Reconstruction of the external ear usually precedes the reconstruction of the middle ear. Often, a template is used by the reconstructive surgeon to aid in this complicated process. Traditionally, templates used by the reconstructive surgeon have been 2 dimensional (usually x-ray paper) and made from the opposite normal ear or another normal ear in cases of bilateral microtia. Use of a 2-dimensional model only provides a rough estimate of the cartilage framework needed. Considerable experience is therefore needed to get this cartilage framework "just right." We have developed a number of 3-dimensional synthetic templates to aid in the creation of an accurate cartilage framework implant. These templates serve as a more accurate guide in the complex cartilage carving and assembly process. The use of 3-dimensional templates has improved our technical reconstructive results in a small number of patients. We present these results and propose future application of these ideas.


Subject(s)
Ear, External/surgery , Models, Structural , Plastic Surgery Procedures , Cartilage/transplantation , Ear, External/abnormalities , Humans
9.
Otolaryngol Head Neck Surg ; 118(1): 86-94, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9450834

ABSTRACT

This report describes the first known investigation of canine laryngeal muscle in which single fibers were dissected and their myosin heavy chain (MHC) isoform content was analyzed. Both SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and western blot techniques were used. The data from single fiber SDS-PAGE indicate that the lateral cricoarytenoid (LCA) is predominantly a fast muscle composed of the following MHC isoforms: Type I, 16.3%; Type IIA, 71.3%; Type IIX, 10.4%; and Type IIB, 2.0%. The results reveal a phenomenon that, to our knowledge, has not been previously described for laryngeal muscle: the presence of two or more MHC isoforms in a single canine LCA muscle fiber. A large number (41%) of muscle fibers coexpressed two or more MHC isoforms. The three most common patterns of coexpression were Type IIA/IIX (72%), Type IIA/I (16%), and Type IIA/IIX/I (8%). Interestingly, the fast Type IIX MHC isoform was typically present with other isoforms and rarely found by itself in individual fibers. Additional experiments are underway to determine whether other laryngeal muscles exhibit such an unusually high ratio of MHC isoform polymorphism.


Subject(s)
Laryngeal Muscles/chemistry , Myosin Heavy Chains/analysis , Animals , Arytenoid Cartilage , Blotting, Western , Cricoid Cartilage , Dogs , Electrophoresis, Polyacrylamide Gel , Myosin Heavy Chains/chemistry
10.
Otolaryngol Clin North Am ; 28(5): 881-95, 1995 Oct.
Article in English | MEDLINE | ID: mdl-8559578

ABSTRACT

This article describes the mechanisms of peripheral nerve healing and the efforts to achieve an optimal healing outcome. The mainstay of treatment has been adherence to good surgical technique and the use of microsurgical equipment. Despite advances in microsurgery, complete structural and functional recovery is uncommon. Research focused on adjunctive methods for nerve repair is also reviewed in this article.


Subject(s)
Microsurgery/methods , Nerve Regeneration/physiology , Peripheral Nerve Injuries , Anastomosis, Surgical/methods , Animals , Humans , Nerve Growth Factors/physiology , Peripheral Nerves/physiopathology , Peripheral Nerves/surgery
11.
Arch Otolaryngol Head Neck Surg ; 120(10): 1074-9, 1994 Oct.
Article in English | MEDLINE | ID: mdl-7917190

ABSTRACT

A survey of fellowship-trained otolaryngologists was undertaken. Seven hundred forty-four questionnaires were mailed, and 344 were returned. The survey respondents were asked questions regarding their fellowship training, location of practice, attitudes regarding certification, relevancy of fellowship to practice, and quality of fellowship training, among others. Results of this survey provide some information regarding the ongoing proliferation of fellowships in Otolaryngology--Head and Neck Surgery and the philosophies of those having taken fellowships. Generally, this survey indicates that fellowship-trained specialists feel that there are enough fellowships currently, and suggestions are made to improve the quality of fellowship training. Almost 70% of this survey's respondents prefer a Certificate of Added Qualifications from the American Board of Otolaryngology for credentialing and validation of their fellowship training.


Subject(s)
Fellowships and Scholarships , General Surgery/education , Internship and Residency , Otolaryngology/education , Accreditation , Adult , Allergy and Immunology/education , Attitude of Health Personnel , Certification , Curriculum , Fellowships and Scholarships/standards , Fellowships and Scholarships/statistics & numerical data , Head/surgery , Humans , Internship and Residency/standards , Internship and Residency/statistics & numerical data , Neck/surgery , Pediatrics/education , Preceptorship , Professional Practice , Professional Practice Location , Surgery, Plastic/education , Time Factors , United States/epidemiology
12.
Otolaryngol Head Neck Surg ; 111(4): 497-508, 1994 Oct.
Article in English | MEDLINE | ID: mdl-7936686

ABSTRACT

The evaluation and treatment of patients with unilateral vocal fold paralysis have evolved as improvements in objective measurements of phonatory function and new modalities for treatment have developed. A thorough history, physical examination, subjective voice evaluation, objective voice analysis, and electromyography are used to make a diagnosis, determine the cause, and plan treatment. The goal of treatment of the patient with a unilateral vocal fold paralysis is to restore normal phonatory function without aspiration. Multiple modalities have developed to allow for restoration of nearly normal phonatory function, and these include voice therapy alone or in combination with injection medialization, laryngoplastic phonosurgery, or laryngeal reinnervation. Otolaryngologists should be familiar with the incidence, cause, evaluation, and state-of-the-art treatment of unilateral vocal fold paralysis of optimize patient care and avoid suboptimal results often seen with antiquated or inappropriate treatment.


Subject(s)
Vocal Cord Paralysis/diagnosis , Vocal Cord Paralysis/therapy , Humans , Vocal Cord Paralysis/etiology , Vocal Cord Paralysis/physiopathology
13.
Arch Otolaryngol Head Neck Surg ; 120(3): 317-25, 1994 Mar.
Article in English | MEDLINE | ID: mdl-8123242

ABSTRACT

OBJECTIVES: To describe the effects of laryngeal insufficiency on aerodynamic and temporal aspects of speech breathing and speech production. DESIGN: A survey study with statistical comparisons of patient and normal subject groups. SETTING: Private and institutional practice. PATIENTS: A convenience sample of 23 subjects with laryngeal insufficiency was compared with a volunteer sample of 20 normal-speaking subjects. Patients had frank unilateral recurrent nerve paralysis-paresis or idiopathic laryngeal insufficiency as verified by videostrobolaryngoscopy. MAIN MEASURES: Mean airflows, air volumes, and durations for speech inspirations, speech phrases, and non-inspiratory pauses during samples of monologue speech. RESULTS: In comparison with the normal group, the patient group had significantly (P < .01) higher expiratory airflows and volumes during speech and reduced speech phrase durations. In addition, breaths per minute, inspiratory minute volume, and inspiratory airflow were significantly (P < .01) higher for the patient group. An experimental measure of aerodynamic yield for speech increased the statistical separation of the patient and normal groups compared with analyses using simple expiratory airflow measures alone. CONCLUSIONS: Insufficient contact of the true vocal folds during speech can affect more than just voice quality. Likely effects include (1) reduced speech phrase duration, (2) increased breaths per minute, (3) increased inspiratory minute volume, and (4) increased inspiratory airflow rate.


Subject(s)
Laryngeal Diseases/physiopathology , Pulmonary Ventilation , Speech Disorders/physiopathology , Speech Production Measurement , Adult , Aged , Female , Humans , Male , Middle Aged , Reference Values , Speech/physiology , Speech Disorders/etiology , Speech Production Measurement/methods
14.
J Voice ; 8(1): 79-83, 1994 Mar.
Article in English | MEDLINE | ID: mdl-8167791

ABSTRACT

Recurrent laryngeal nerve (RLN) injury [without injury to the superior laryngeal nerve (SLN)] is the most common traumatic neurolaryngological lesion. The acute effects are immediate flaccidity of the ipsilateral vocal fold, loss of abduction and adduction, severe dysphonia to complete paralytic aphonia, and, frequently, aspiration of food and drink into the trachea. This article reviews the function of the four intrinsic laryngeal muscles innervated by the RLN and the individual effects of RLN transection on these muscles. Following acute denervation, the subsequent progression is either chronic denervation or nerve regeneration with laryngeal muscle reinnervation. Four possible scenarios are discussed here: complete reinnervation with synkinesis, partial reinnervation with synkinesis, mixed RLN injuries, and no reinnervation (complete paralysis). Electromyography may eventually assist the laryngologist in establishing these diagnoses, but currently not enough normative data exist for confirming laryngeal synkinesis unequivocally in every case. Treatment is generally by Teflon injection, medialization thyroplasty, arytenoid adduction procedures, or reinnervation by nerve transfer. The author's preference is nerve transfer, insofar as the quality of resultant phonatory voice, in his hands, has been superior to the other techniques.


Subject(s)
Laryngeal Muscles/physiopathology , Laryngeal Nerves/physiopathology , Vocal Cord Paralysis/physiopathology , Humans , Muscle Denervation , Nerve Regeneration , Pneumonia, Aspiration/etiology , Vocal Cord Paralysis/complications
15.
16.
Ann Otol Rhinol Laryngol ; 102(2): 81-4, 1993 Feb.
Article in English | MEDLINE | ID: mdl-8427504

ABSTRACT

A review of our recent experience in patients with bilateral laryngeal paralysis is described. While we continue to use phrenic nerve transfers in patients with mobile arytenoids, patients with fixed arytenoids generally require some sort of vocal cord lateralization, either by arytenoidectomy and arytenoidopexy or by partial vocal cord resection. The endoscopic laser medial arytenoidectomy is a convenient and effective method for opening the posterior glottic airway. One arytenoid is reduced medially with the carbon dioxide laser. After about 3 months the opposite arytenoid can be treated similarly, if necessary. The procedure does not appear to affect arytenoid mobility, as the posterior commissure mucosa and underlying interarytenoid muscle are protected and hence unaffected by the procedure. Those patients with at least one mobile arytenoid cartilage are candidates for posterior cricoarytenoid muscle reinnervation. Although ansa cervicalis and phrenic nerve techniques have been described, the author has concentrated efforts on the phrenic nerve. This report describes the endoscopic laser medial arytenoidectomy procedure, while the phrenic nerve patients will be reported in a subsequent manuscript.


Subject(s)
Arytenoid Cartilage/surgery , Laser Therapy/methods , Vocal Cord Paralysis/surgery , Humans , Laryngoscopy , Laryngostenosis/surgery , Nerve Transfer , Phrenic Nerve/surgery , Tracheotomy
17.
Otolaryngol Head Neck Surg ; 107(1): 14-20, 1992 Jul.
Article in English | MEDLINE | ID: mdl-1528597

ABSTRACT

The repair of injured or transected nerves is frequently encountered in head and neck surgery. Recently, CO2 lasers with milliwatt capability and micrometer spot sizes have been developed that may be used in nerve anastomosis. A comparative study was performed between microsuture and CO2 laser repair of transected sciatic nerves in rats. Nerve regeneration was measured in terms of morphology, electrophysiology, and function. Histologic studies revealed no difference in the size and number of regenerated axons, although there was less scar tissue formation at the anastomotic site with the laser repair. EMG and nerve conduction velocity were similar for the two repair methods. Functional recovery, as determined objectively using measurements of gait footprints, showed no difference between suture and laser repair. Laser-repaired nerves did have a higher dehiscence rate, although this problem can probably be prevented by splinting the rats postoperatively. However, laser repair was faster and simpler than suture repair and required less manipulation of the nerve. This study shows laser repair of peripheral nerves is possible with results comparable to conventional microsuture neurorrhaphy. Laser nerve anastomosis may be an effective alternative to suture nerve repair.


Subject(s)
Anastomosis, Surgical/methods , Laser Therapy , Neurosurgical Procedures , Suture Techniques , Animals , Nervous System/anatomy & histology , Nervous System Physiological Phenomena , Neural Conduction , Postoperative Care , Rats , Rats, Inbred Strains , Sciatic Nerve/anatomy & histology , Sciatic Nerve/injuries , Sciatic Nerve/physiology , Sciatic Nerve/surgery , Trauma, Nervous System
18.
Ann Otol Rhinol Laryngol ; 101(6): 472-8, 1992 Jun.
Article in English | MEDLINE | ID: mdl-1610064

ABSTRACT

A retrospective review of 45 children with mucopolysaccharidoses was performed to determine the frequency of complications related to the head and neck. In this series, every patient had at least one complication involving the head and neck region, and in over half, operative intervention by the otolaryngologist was required. Upper airway obstruction occurred in 17 (38%) and necessitated a tracheostomy in 7 (16%). Cervical spine instability occurred in 8 (18%), making airway management difficult. Recurrent respiratory infections occurred in 17 (38%), and chronic recurrent middle ear effusions were noted in 33 (73%). This review demonstrates that children afflicted with the mucopolysaccharidoses frequently have otolaryngologic-related complications that are common throughout their life span and often the primary management issue in their continuing care. The otolaryngologic management of these patients is outlined based on the results of this study and review of the relevant literature.


Subject(s)
Ear Diseases/etiology , Laryngeal Diseases/etiology , Mucopolysaccharidoses/complications , Adolescent , Airway Obstruction/etiology , Airway Obstruction/surgery , Child , Ear Diseases/epidemiology , Ear Diseases/surgery , Humans , Incidence , Joint Instability/etiology , Laryngeal Diseases/epidemiology , Laryngeal Diseases/surgery , Magnetic Resonance Imaging , Male , Mucopolysaccharidoses/pathology , Spinal Diseases/etiology
19.
Head Neck ; 14(3): 243-6, 1992.
Article in English | MEDLINE | ID: mdl-1587742

ABSTRACT

Silvadene cream and Sulfamylon make up the treatment regimen for one contributor (Dr. Crumley). No systemic antibiotics would be given. Any areas of obvious third-degree burns would be debrided and grafted. The tympanic membrane perforation would be treated with antibiotic/steroid drops. The second author concurs with use of Silvadene cream and would avoid any pressure on the area (Dr. Abemayor). While he agrees that systemic antibiotics should be avoided, he also would not prescribe ear drops. He recommends evaluation for a pulmonary or ophthalmologic injury. There is a disagreement regarding imaging studies. One expert would order a CT scan to rule out facial fractures (Dr. Crumley). His counterpart would not order a CT but would check a baseline chest x-ray if there were any sign of pulmonary compromise (Dr. Abemayor). Both experts would obtain an audiogram after the acute problems are treated. In the case of foul drainage, burn reconstruction would be delayed. In addition to treating the otorrhea with ear drops, one physician would add oral antibiotics (Dr. Abemayor). The other author believes tympanoplasty should be performed prior to reconstruction (Dr. Crumley). There were several procedures suggested for the reconstruction. Both authors discuss a method of creating a postauricular pocket, burying the ear pedicle, and using costal cartilage for an inlay helical graft. Another approach involves minimal debridement of the cartilage and letting the wound mature for 6 to 8 months. At that time the area would be debrided and the postauricular skin used for external coverage (Dr. Crumley). If the facial scar is a cosmetic problem 1 year after the injury, triamcinolone injections and local massage should be considered.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Burns/drug therapy , Ear, External/injuries , Mafenide/therapeutic use , Silver Sulfadiazine/therapeutic use , Steam/adverse effects , Adult , Burns/etiology , Burns/surgery , Ear, External/surgery , Humans , Male , Tympanic Membrane/injuries
20.
Arch Otolaryngol Head Neck Surg ; 118(3): 277-80, 1992 Mar.
Article in English | MEDLINE | ID: mdl-1554448

ABSTRACT

Suture repair of cranial and peripheral nerves has reached a maximal level with the use of advanced microneurorrhaphy techniques; however, functional recovery of the repaired nerve is still often unsatisfactory due to misrouted axonal regrowth. Freeze-trimming the nerve ends prior to anastomosis has been shown to significantly improve fascicular alignment and subsequent functional recovery. This study assessed the feasibility of using laser energy to trim the nerve ends prior to suture anastomosis. The 302-nm excimer laser was used to trim the severed sciatic nerve ends prior to anastomosis in 28 rats. Scanning electron and light microscopy, horseradish peroxidase retrograde labeling, nerve conduction velocity, and functional recovery were assessed postoperatively. The excimer laser was able to trim the nerve ends flat thereby facilitating the coaptation and alignment of the nerve ends. Misrouting of axons occurred in both the laser-trim and control groups. Although this technique has theoretical advantages, no statistically significant improvement was demonstrated in this investigation. This may have been in part due to the small sample size, since a small increment of improvement was noted. It is possible, however, with continued refinements in technique that a functional improvement may be seen in subsequent studies.


Subject(s)
Anastomosis, Surgical/methods , Laser Therapy/methods , Peripheral Nerves/physiopathology , Peripheral Nerves/surgery , Animals , Horseradish Peroxidase , Male , Microscopy, Electron, Scanning , Nerve Regeneration , Neural Conduction , Peripheral Nerves/pathology , Rats , Rats, Inbred Strains , Sciatic Nerve/pathology , Sciatic Nerve/physiopathology , Sciatic Nerve/surgery , Suture Techniques
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