ABSTRACT
BACKGROUND: The purpose of this study was to quantify the effect of treatment duration on locoregional progression after definitive concurrent chemoradiation (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). METHODS: We conducted a retrospective chart review of patients treated between 2004 and 2010. After a prior analysis, measures were taken to limit therapy beyond 7 weeks. Comparison of outcomes were made between cohorts 1 (2004-2007, n = 78) and 2 (2007-2010, n = 62). RESULTS: Median therapy duration was statistically significantly different between cohorts as follows: 51 days, cohort 1 and 46 days, cohort 2 (p < .01). Locoregional progression in cohorts 1 and 2 was 19% and 5% (p = .01), respectively. On multivariate analysis, patients with prolonged treatment (≥57 days) had an 8-fold increase in risk of locoregional progression compared to patients who completed on time (p < .01). CONCLUSION: Treatment duration was a significant predictor of locoregional progression in patients with SCCHN who received definitive CCRT.
Subject(s)
Carcinoma, Squamous Cell/therapy , Chemoradiotherapy , Head and Neck Neoplasms/therapy , Radiotherapy, Intensity-Modulated , Adult , Aged , Aged, 80 and over , Disease Progression , Female , Humans , Male , Middle Aged , Multivariate Analysis , Neoplasm Recurrence, Local , Retrospective Studies , Squamous Cell Carcinoma of Head and Neck , Time Factors , Treatment FailureABSTRACT
Objective: To characterize the semen quality of Filipino male partners of couples with infertility and determine the effects of age. Design: Retrospective study. Setting: Andrology laboratory at a tertiary care hospital. Patients: 2,701 males. Main Outcome Measures: Routine semen analysis. Results: Average age of the study population was older and azoospermia occurence was lower than in previous studies. A large proportion had parameters below the WHO reference values. A decreasing trend for all semen parameters across increasing age was observed. For males -51 years old almost all parameters were below WHO values. Subject with abnormal parameters were significantly increasing across age. Occurence of severe oligozoospermia in older males was significantly increased compared to younger males. Conclusion: The study characterized the current status of semen quality in this subpopulation, a very large proportion of which had values below WHO reference. The data illutrate that as men age, semen quality declines.
Subject(s)
Humans , Male , Middle Aged , Adult , Young Adult , Male , Semen AnalysisABSTRACT
Objective: To describe the 6 clinical cases of unicornuate uterus managed at a tertiary hospital. Design: Case series from 2000-August 2004. Setting: University Hospital Main Outcome Measured: Presence of renal anomalies, fertility, outcome of pregnancies, concomitant endometriosis. Results: Unicornuate uterus with a right functioning non-communicating horn was the most common anomaly. Renal agenesis was observed in 67 percent. Four women produced 9 pregnancies. Sixty seven percent of pregnancies resulted in live births. There were 2 pre-term pregnancies and four term pregnancies. There was 33 percent incidence of ectopic pregnancy, 2 of which were in the rudimentary horn. The individual risk for having a rudimentary horn pregnancy is as high as 50 percent. The incidence of endometriosis with hematometra of the rudimentary horn was 33 percent. A hemihysterectomy was done for 4 patients with either hematometra or rudimentary horn pregnancies. Conclusions: Unicornuate uterus has unimpaired reproductive potential. The anomaly was usually discovered due to complication in the rudimentary horn.
Subject(s)
Humans , UterusABSTRACT
En este trabajo de investigación se estableció un modelo experimental adecuado para demostrar la actividad amebicida in vitra de plantas usadas en el tratamiento de diarrea, se realizaron ensayos in vitro con 10 extractos de 5 plantas nativas de Guatemala para observar el efecto que tienen sobre la viabilidad de los trofozoitos de Entamoeba histolytica. Para ello se requirió el uso de 3 métodos para cuantificar la viabilidad de los trofozoitos. Dos métodos que consisten en el conteo de trofozoitos vivos posterior a una incubación a 37°C por 24h con el extracto de cada planta en tubos Eppendorf y placas de 96. El tercer método consiste en la cuantificación espectrofotométrica utillizando sal de tetrazolio. Se realizaron 7 ensayos en triplicado utilizando 3 concentraciones de cada extracto 1, 0.5 y0.250 mg/ml enfrentados a 3x10(4) trofozoitos de E. histolytica.
