Frequency of human papillomavirus infection in patients with gastrointestinal cancer. / Frecuencia de infección por virus del papiloma humano en pacientes con cáncer del aparato digestivo.

INTRODUCTION AND AIM: Cancer is the result of the interaction of genetic and environmental factors. It has recently been related to viral infections, one of which is human papillomavirus. The aim of the present study was to describe the frequency of human papillomavirus infection in patients with digestive system cancers. MATERIALS AND METHODS: A prospective, multicenter, observational study was conducted on patients with gastrointestinal cancer at 2public healthcare institutes in Veracruz. Two tumor samples were taken, one for histologic study and the other for DNA determination of human papillomavirus and its genotypes. Anthropometric variables, risk factors, sexual habits, tumor location, and histologic type of the cancer were analyzed. Absolute and relative frequencies were determined using the SPSS version 24.0 program. RESULTS: Fifty-three patients were studied. They had gastrointestinal cancer located in: the colon (62.26%), stomach (18.87%), esophagus (7.55%), rectum (7.55%), and small bowel (3.77%). Human papillomavirus was identified in 11.32% of the patients, 66.7% of which corresponded to squamous cell carcinoma and 33.3% to adenocarcinoma. Only genotype 18 was identified. Mean patient age was 61.8±15.2 years, 56.60% of the patients were men, and 43.40% were women. A total of 15.8% of the patients had a family history of cancer and 31.6% had a personal history of the disease, 38.6% were tobacco smokers, and 61.4% consumed alcohol. Regarding sex, 5.3% of the patients said they were homosexual, 3.5% were bisexual, 29.8% engaged in oral sex, and 24.6% in anal sex. CONCLUSIONS: Our study showed that human papillomavirus infection was a risk factor for the development of gastrointestinal cancer, especially of squamous cell origin.

[Three prognostic utility scales to determine early mortality in patients with alcoholic hepatitis in the General Hospital of Mexico]. / Utilidad de tres escalas pronósticas para determinar mortalidad temprana en pacientes con hepatitis alcohólica en el Hospital General de México.

BACKGROUND: There are many models to predict survival in patients with alcoholic hepatitis (AH). The most commonly used are the modified Maddrey's index, the Glasgow scale and the Model for End stage Liver Disease (MELD). OBJECTIVE: To evaluate three prognostic scales ability to predict early mortality (first 30 days) in patients with AH. METHODS: We retrospectively reviewed the database of hospitalized patients with AH during a 3-years period. Seventy one patients were included. We calculated the modified Maddrey's index, the Glasgow scale and the MELD scores. We evaluated if the scales predicted early (30-day) mortality. For each scale we determined sensitivity, specificity, positive and negative values (PPV and NPV) and likelihood value of each scale. RESULTS: For modified Maddrey's index, the values obtained were sensitivity 98.8%, specificity 11.7%, PPV 61.6%, NPV 87.5% and likelihood ratio 1.12. For Glasgow scale corresponding values were sensitivity 98.8%, specificity 61.7%, PPV 78.7%, NPV 97.4% and likelihood ratio 2.64. For the MELD scale sensitivity 98.8%, specificity 0.1%, PPV 59%, NPV 50% and likelihood ratio 1. CONCLUSIONS: The three scales were very sensitive. Glasgow's scale was the most specific and, maybe, the most exact test.

[The amount of alcohol intake, upper gastrointestinal bleeding, acute renal failure and hepatic encephalopathy as the risk factors implied in the increase of patients with alcoholic hepatitis]. / Cantidad de alcohol, hemorragia de tubo digestivo alto, insuficiencia renal aguda y encefalopatía hepática como factores de riesgo implicados en el incremento de la mortalidad en pacientes con hepatitis por alcohol.

BACKGROUND: Acute renal failure (ARF) worsens the prognosis of patients with alcoholic hepatitis (HA). Other factors like the amount of alcohol intake, upper gastrointestinal bleeding (UGB) or hepatic encephalopathy (HE) are not considered at present in any prognostic index. OBJECTIVE: To evaluate if the amount of alcohol intake, development of UGB, ARF and/or HE are associated with high mortality in patients with AH. METHODS: Consecutive patients with diagnosis of AH were included. Demographic, laboratory data, complications and mortality were registered. A comparison was performed between survivors and non-survivors. RESULTS: Seventy-one patients were included. Median amount of alcohol consumption was 187.7 g/day, and was superior in men (190.8 vs. 169 g/day, p = 0.02) and in patients who developed ARF (219.6 vs. 144.1 g/day, p = 0.001). Maddrey s index was higher in patients who died than those who survive (111.4 vs. 52.9, p = 0.02). No differences between groups were recorded regarding Glasgow and MELD scales. ARF was the only one complication related with higher risk of death (RR = 6.7, p = 0.02). Isolated UGB and HE were non-significantly associated with mortality, but combination of two or three complications was highly significantly associated with mortality risk: ARF and HE (OR = 8.9, p = 0.001), HE and UGB (OR = 6.7, p = 0.01) and ARF + UGB + HE (OR = 10, p = 0.001). CONCLUSION: The amount of alcohol intake is associated with development of ARF. ARF was the most significant risk factor associated with mortality. The presence of two or three complications increases the mortality risk significantly. Key words: acute renal failure, hepatic encephalopathy, risk factors, mortality, alcoholic hepatitis, Mexico.