ABSTRACT
BACKGROUND: Critical COVID-19 survivors are at risk of developing Post-intensive Care Syndrome (PICS) and Chronic ICU-Related Pain (CIRP). We determined whether a specific care program improves the quality of life (QoL) of patients at risk of developing PICS and CIRP after COVID-19. METHODS: The PAIN-COVID trial was a parallel-group, single-centre, single-blinded, randomized controlled trial. The intervention consisted of a follow up program, patient education on PICS and pain, and a psychological intervention based on Rehm's self-control model in patients with abnormal depression scores (≥8) in the Hospital Anxiety and Depression Scale (HADS) at the baseline visit. QoL was evaluated with the 5-level EQ 5D (EQ 5D 5â¯L), mood disorders with the HADS, post-traumatic stress disorder (PTSD) with the PCL-5 checklist, and pain with the Brief Pain Inventory short form, the Douleur Neuropathique 4 questionnaire, and the Pain Catastrophizing Scale. The primary outcome was to determine if the program was superior to standard-of-care on the EQ visual analogue scale (VAS) at 6 months after the baseline visit. The secondary outcomes were EQ VAS at 3 months, and EQ index, CIRP incidence and characteristics, and anxiety, depression, and PTSD at 3 and 6 months after baseline visits. CONCLUSIONS: This program was not superior to standard care in improving QoL in critical COVID-19 survivors as measured by the EQ VAS. However, our data can help establish better strategies for the study and management of PICS and CIRP in this population. TRIAL REGISTRATION: # NCT04394169, registered on 5/19/2020.
Subject(s)
COVID-19 , Chronic Pain , Quality of Life , Humans , COVID-19/complications , COVID-19/psychology , Chronic Pain/therapy , Chronic Pain/psychology , Chronic Pain/etiology , Female , Male , Single-Blind Method , Middle Aged , Depression/etiology , Depression/therapy , Aged , Anxiety/etiology , Anxiety/therapy , Critical Care/methods , Critical Care/psychology , Stress Disorders, Post-Traumatic/etiology , Stress Disorders, Post-Traumatic/therapy , Follow-Up Studies , Pain Measurement/methods , Pain Management/methods , Patient Education as Topic , Aftercare/methods , Intensive Care Units , Treatment Outcome , Critical IllnessABSTRACT
Genicular nerves block is a promising technique to treat acute postoperative pain in total knee arthroplasty. Similar to surgeon-administered local infiltration analgesia, it targets sensory branches from the knee capsule, but through a selective ultrasound-guided injection that reduces local anaesthetic dose (150 ml ropivacaine 0.2% with local infiltration analgesia vs. 20 ml with genicular nerves block). This randomised non-inferiority trial compared the analgesic efficacy of genicular nerves block vs. local infiltration analgesia in the first 24 h following total knee arthroplasty. Sixty patients were randomly allocated to receive either ultrasound-guided block of five genicular nerves or local infiltration analgesia. The primary outcome was rest pain numeric rating scale (0-10) at 24 h. Secondary outcomes included pain numeric rating scale (rest and movement) and cumulative opioid consumption during the first 24 h. We analysed 29 patients in the genicular nerves block group and 30 in the local infiltration analgesia group. We found that the median difference (95%CI) in postoperative rest pain at 24 h (non-inferiority criteria, Δ = 1) was -1.0 (-2.0 to 1.0, p < 0.001). Median difference in cumulative opioid consumption was 0.0 mg (-3.0-5.0, p < 0.001) meeting the non-inferiority criteria, Δ = 23 mg. We conclude that genicular nerves block of five nerves provides non-inferior analgesia in the first 24 h following surgery compared with local infiltration analgesia, but with a considerable reduction in the local anaesthetic dose.
Subject(s)
Analgesia , Arthroplasty, Replacement, Knee , Nerve Block , Humans , Anesthetics, Local , Analgesics, Opioid/therapeutic use , Nerve Block/methods , Analgesia/methods , Pain, Postoperative/drug therapy , Pain, Postoperative/prevention & control , Analgesics/therapeutic use , Ultrasonography, InterventionalABSTRACT
La artroplastia total de rodilla es una de las cirugías realizadas con más frecuencia en ortopedia. No obstante, hasta un 20% de los pacientes mostrarán persistencia del dolor después del procedimiento. El dolor posquirúrgico persistente puede ser una continuación del dolor agudo tras la cirugía o aparecer después de un período asintomático durante más de 3 meses.En la actualidad, se han caracterizado los factores de riesgo que se asocian a dolor posquirúrgico persistente tras la artroplastia total de rodilla. Forman parte del contexto perioperatorio del paciente (preoperatorio, intraoperatorio y postoperatorio) y se pueden agrupar en diferentes dimensiones: genéticas, demográficas, clínicas, quirúrgicas, analgésicas, inflamatorias y psicológicas.Su identificación y prevención, mediante un abordaje multimodal y biopsicosocial, es esencial en el contexto de la medicina perioperatoria y ha demostrado que puede prevenir o mejorar el dolor tras la cirugía.(AU)
Subject(s)
Humans , Male , Female , Perioperative Nursing , Arthroplasty, Replacement, Knee , Orthopedics , Anesthesiology , Pain, Postoperative , Pain Management , Chronic Pain/prevention & control , Risk Factors , Preoperative Care , Demography , Anxiety , Catastrophization , Postoperative Care , ComorbidityABSTRACT
Total knee arthroplasty is one of the most frequently performed orthopaedic surgeries. However, up to 20% of patients develop persistent postoperative pain. Persistent postoperative pain may be an extension of acute postoperative pain, but can also occur after more than 3 months without symptoms. Risk factors associated with persistent postoperative pain after arthroplasty have now been characterised within the patient's perioperative context (preoperative, intraoperative and postoperative), and can be grouped under genetic, demographic, clinical, surgical, analgesic, inflammatory and psychological factors. Identification and prevention of persistent postoperative pain through a multimodal and biopsychosocial approach is essential in the context of perioperative medicine, and has been shown to prevent or ameliorate postoperative pain.
Subject(s)
Arthroplasty, Replacement, Knee , Knee Prosthesis , Perioperative Medicine , Analgesics/therapeutic use , Arthroplasty, Replacement, Knee/adverse effects , Humans , Knee Prosthesis/adverse effects , Pain, Postoperative/drug therapyABSTRACT
Total knee arthroplasty is one of the most frequently performed orthopaedic surgeries. However, up to 20% of patients develop persistent postoperative pain. Persistent postoperative pain may be an extension of acute postoperative pain, but can also occur after more than 3 months without symptoms. Risk factors associated with persistent postoperative pain after arthroplasty have now been characterised within the patient's perioperative context (preoperative, intraoperative and postoperative), and can be grouped under genetic, demographic, clinical, surgical, analgesic, inflammatory and psychological factors. Identification and prevention of persistent postoperative pain through a multimodal and biopsychosocial approach is essential in the context of perioperative medicine, and has been shown to prevent or ameliorate postoperative pain.
