ABSTRACT
Existen una serie de tumores asociados al gastrointestinal stromal tumour (GIST, «tumor del estroma gastrointestinal»), la mayoría de los cuales ocurren sin una aparente relación familiar; solo un 5% suceden en el contexto de síndromes familiares. En este artículo se ha revisado la literatura médica existente sobre los primeros. Se ha elaborado una búsqueda en Pubmed cuya metodología se concreta en el cuerpo del artículo Han sido seleccionados para la revisión un total de 88 artículos tras la aplicación de límites y revisión manual. Los pacientes con GIST tienen un riesgo aproximadamente 2 veces mayor que la población general de desarrollar otro tumor (4-33% de ellos desarrollan una segunda neoplasia, ya sea sincrónica o metacrónica). Los tumores más frecuentemente asociados son los de origen gastrointestinal y genitourinario. Además, los pacientes con segundos tumores tienen una supervivencia peor que aquellos que padecen únicamente un GIST (AU)
There are several tumours associated with gastrointestinal stromal tumour (GIST), most of them without an apparent family relationship; only 5% of them occur within the context of a family syndrome. In this article the corresponding literature about the former has been reviewed. A search in Pubmed was carried out, the methodology of which is described in detail in the body of the article. A total of 88 articles have been chosen for the review, next to the application of limits as well as a manual review. GIST patients have a twofold risk of developing a second tumour than the general population (4-33% of them develop a second neoplasm, either synchronic or metachronic). Most incident tumours associated with GIST are gastrointestinal and genitourinary tumours. In addition, patients with second tumours have a worse survival rate than those without second tumours (AU)
Subject(s)
Humans , Gastrointestinal Stromal Tumors/pathology , Neoplasms, Multiple Primary/pathology , Neoplasms, Second Primary/pathology , Neoplasm Recurrence, Local/pathologyABSTRACT
There are several tumours associated with gastrointestinal stromal tumour (GIST), most of them without an apparent family relationship; only 5% of them occur within the context of a family syndrome. In this article the corresponding literature about the former has been reviewed. A search in Pubmed was carried out, the methodology of which is described in detail in the body of the article. A total of 88 articles have been chosen for the review, next to the application of limits as well as a manual review. GIST patients have a twofold risk of developing a second tumour than the general population (4-33% of them develop a second neoplasm, either synchronic or metachronic). Most incident tumours associated with GIST are gastrointestinal and genitourinary tumours. In addition, patients with second tumours have a worse survival rate than those without second tumours.
Subject(s)
Gastrointestinal Neoplasms , Gastrointestinal Stromal Tumors , Neoplasms, Multiple Primary , Neoplasms, Second Primary , Urogenital Neoplasms , Gastrointestinal Neoplasms/diagnosis , Gastrointestinal Neoplasms/pathology , Gastrointestinal Stromal Tumors/diagnosis , Gastrointestinal Stromal Tumors/pathology , Humans , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Multiple Primary/pathology , Neoplasms, Second Primary/diagnosis , Neoplasms, Second Primary/pathology , Prognosis , Risk , Urogenital Neoplasms/diagnosis , Urogenital Neoplasms/pathologyABSTRACT
Soft tissue sarcomas are uncommon tumors of mesenchimal cell origin. Criteria for suspicion is a soft tissue mass that is increasing in size, and has a size greater than 5 cm or is located under the deep fascia. Diagnosis and management of these patients should preferably be performed by a specialist multidisciplinary team in a referral center. Assessment of a patient with a suspect of sarcoma should include magnetic resonance and biopsy performed prior to surgery. Primary local therapy for patients with localized sarcoma is based on wide surgical resection with a tumor-free tissue margin, in association in most cases with radiotherapy. Adjuvant chemotherapy constitutes an option that could be considered in high-risk sarcomas of the extremities. When metastasis are present, surgery of pulmonary lesions, in some selected patients, and chemotherapy are current available options.
Subject(s)
Practice Guidelines as Topic , Sarcoma/therapy , Adult , Algorithms , Decision Trees , Humans , Medical Oncology/legislation & jurisprudence , Neoplasm Metastasis , Neoplasm Staging/methods , Sarcoma/diagnosis , Sarcoma/pathology , SpainSubject(s)
Medical Errors , Medical Oncology , Neoplasms/diagnosis , Neoplasms/therapy , Humans , RiskABSTRACT
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