Subject(s)
Astrocytoma , Cerebellar Neoplasms , Radiotherapy/adverse effects , Adult , Astrocytoma/diagnosis , Astrocytoma/etiology , Astrocytoma/pathology , Cerebellar Neoplasms/complications , Cerebellar Neoplasms/diagnosis , Cerebellar Neoplasms/pathology , Cerebellar Neoplasms/radiotherapy , Fatal Outcome , Humans , Magnetic Resonance Imaging , Male , Radiation, IonizingSubject(s)
Humans , Male , Adult , /diagnosis , /etiology , /secondary , /complications , /diagnosis , /pathology , /radiotherapy , RadiotherapyABSTRACT
INTRODUCTION: Infections of the central nervous system by free-living amoeba are a rare phenomenon around the world. They present as a necrotising haemorrhagic acute meningoencephalitis, with a fatality rate close to 100% or as granulomatous amoebic encephalitis with a chronic progression. CASE REPORT: We describe a fatal case of primary amoebic meningoencephalitis produced by Naegleria fowleri in an 8-year-old child, with a history of immersion in a freshwater reservoir 52 hours before death. CONCLUSION: Laboratory studies carried out before death did not enable a diagnosis to be reached while the patient was alive. Diagnosis was made in the course of the post-mortem examination, where the presence of amoeba trophozoites was identified.
Subject(s)
Amebiasis/complications , Meningoencephalitis/etiology , Meningoencephalitis/parasitology , Amebiasis/diagnosis , Amebiasis/pathology , Animals , Child , Fatal Outcome , Humans , Male , Meningoencephalitis/diagnosis , Meningoencephalitis/pathology , Naegleria fowleri/metabolismABSTRACT
Introducción. Las infecciones del sistema nervioso central producida por amebas de vida libre constituyen un fenómeno raro mundialmente. Ésta se presenta como una meningoencefalitis aguda hemorrágica necrotizante, con una letalidad cercana al 100 por ciento, o como una encefalitis granulomatosa amebiana de evolución crónica. Caso clínico. Se comunica un caso letal de meningoencefalitis amebiana primaria producida por Naegleria fowleri en un niño de 8 años, con el antecedente de inmersión en un embalse de agua dulce 52 horas antes de la muerte. Conclusión. Los estudios de laboratorio realizados antes del fallecimiento no permitieron el diagnóstico en vida del paciente. El diagnóstico se realizó en el estudio necrópsico, donde se identificó la presencia de trofozoítos de amebas (AU)
Introduction. Infections of the central nervous system by free-living amoeba are a rare phenomenon around the world. They present as a necrotising haemorrhagic acute meningoencephalitis, with a fatality rate close to 100% or as granulomatous amoebic encephalitis with a chronic progression. Case report. We describe a fatal case of primary amoebic meningoencephalitis produced by Naegleria fowleri in an 8-year-old child, with a history of immersion in a freshwater reservoir 52 hours before death. Conclusion. Laboratory studies carried out before death did not enable a diagnosis to be reached while the patient was alive. Diagnosis was made in the course of the post-mortem examination, where the presence of amoeba trophozoites was identified (AU)
Subject(s)
Humans , Child , Animals , Male , Fatal Outcome , Naegleria fowleri , Meningoencephalitis , AmebiasisSubject(s)
Brain Neoplasms/pathology , Gliosarcoma/pathology , Aged , Female , Humans , Male , Middle AgedABSTRACT
No disponible
Subject(s)
Middle Aged , Child , Aged , Male , Female , Humans , Rett Syndrome , Gliosarcoma , Psychiatric Status Rating Scales , Diagnosis, Differential , Severity of Illness Index , Brain NeoplasmsABSTRACT
A twenty-four-year-old woman presented with asthenia, anorexia and weight los associated with headache, neck ache, lumbo-sacral pain, flaccid quadriparous, bilaterally diminished vision and sphincter disorders. On computerized axial tomography of the skull, only slight signs of ventricular dilatation were seen. Cytochemical study of the cerebro-spinal fluid showed a marked increase in protein and there was a raised erythrocyte sedimentation rate. The patient was treated with steroids in view of the possibility of vasculitis or a demyelinating disorder. However the disease worsened and she died four months after onset of the disorder. Neuro-pathological study showed tumour infiltration of the leptomeninges of the base of both cerebral hemispheres, cerebellum and spinal medulla. The optic nerves, chiasma and spinal nerve roots were also infiltrated with neoplastic cells. No intraparenchymatous tumour was found. The neuropathological findings were compatible with primary diffuse leptomeningeal gliomatosis.
