Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Acta Psychiatr Scand ; 128(3): 149-62, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23617548

ABSTRACT

OBJECTIVE: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. METHOD: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task. RESULTS: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression. CONCLUSION: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.


Subject(s)
Affective Symptoms , Bipolar Disorder , Cognition Disorders , Mental Competency , Neuropsychological Tests , Psychotropic Drugs/adverse effects , Adult , Affect , Affective Symptoms/psychology , Age of Onset , Bipolar Disorder/complications , Bipolar Disorder/diagnosis , Bipolar Disorder/drug therapy , Bipolar Disorder/epidemiology , Cognition Disorders/diagnosis , Cognition Disorders/drug therapy , Cognition Disorders/epidemiology , Cognition Disorders/etiology , Confounding Factors, Epidemiologic , Female , Humans , Male , Mental Processes/drug effects , Middle Aged , Psychiatric Status Rating Scales , Psychotropic Drugs/administration & dosage , Risk Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...