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1.
Recenti Prog Med ; 92(9): 537-9, 2001 Sep.
Article in Italian | MEDLINE | ID: mdl-11552310

ABSTRACT

Scombroid poisoning is a form of ichthyosarcotoxism caused by eating spoiled fish, mainly of the scombroid family. Inappropriate storage of these fish can lead to the decarboxylation of histidine in the flesh to histamine by enterobacteria. The symptoms of histamine poisoning mimic those of an IgE-mediated food allergy, as well as flushing, headache, diarrhea and palpitations. However, in some cases, the scombroid poisoning can be characterized by very serious symptoms, as well as cardiovascular compromission. We describe two cases of scombroid poisoning with severe hypotension requiring continuous intravenous dopamine with resolution of symptoms only several hours later.


Subject(s)
Cardiovascular Diseases/etiology , Food Preservation , Marine Toxins/poisoning , Adult , Female , Humans , Male , Severity of Illness Index , Syndrome , Time Factors
2.
Recenti Prog Med ; 91(10): 511-2, 2000 Oct.
Article in Italian | MEDLINE | ID: mdl-11072739

ABSTRACT

Ticlopidine is an antiplatelet agent that is used to reduce the occurrence of atherothrombotic arterial events, but it can sometime cause severe haematological side-effects. We describe the case of a 79-year old woman suffering from ischaemic cardiopathy and chronic cerebral vasculopathy treated with ticlopidine, who developed a rare pancytopenia on the 26th day of ticlopidine treatment. The patient was successful treated with intravenous antibiotics and with filgrastim, with complete reversion of the pancytopenia.


Subject(s)
Fibrinolytic Agents/adverse effects , Granulocyte Colony-Stimulating Factor/therapeutic use , Pancytopenia/drug therapy , Platelet Aggregation Inhibitors/adverse effects , Ticlopidine/adverse effects , Aged , Anti-Bacterial Agents/therapeutic use , Female , Filgrastim , Humans , Pancytopenia/chemically induced , Recombinant Proteins
4.
Clin Exp Rheumatol ; 12(5): 515-21, 1994.
Article in English | MEDLINE | ID: mdl-7842532

ABSTRACT

OBJECTIVE: Rheumatic diseases are a group of systemic disorders that may be concurrent with Raynaud's phenomenon and involvement of the internal organs, in particular the esophagus. Esophageal motor abnormalities have been widely described in systemic sclerosis, but have not frequently been reported in other diseases. In the present study we have examined the prevalence and pattern of esophageal motility disorders in different rheumatic diseases. METHODS: Esophageal manometry was performed on 150 patients, 21 males and 129 females, suffering from different rheumatic diseases (SSc, RA, SLE, MCTD, undifferentiated CTD, or DM/PM) and on 30 healthy controls. RESULTS: Functional involvement of the esophagus was demonstrated in all the rheumatic diseases considered, although at varying percentages. The frequencies of the functional abnormalities differed when each disease was considered separately. In SSc patients abnormalities were found more frequently in the lower esophageal sphincter (81.8%) and in the esophageal body (84.8%); data for the DM/PM and MCTD patients broadly overlapped. On the contrary, in SLE the lower sphincter appeared to be less (or even not at all) impaired, while the most specific disorder was an isolated abnormal peristalsis. RP did not always correlate with manometric changes in all of the groups studied. CONCLUSIONS: Three conclusions derive from our study: i) motor disorders affecting the esophagus were not only found in SSc, but also in all forms of non-lupus CTD; ii) the simultaneous involvement of the esophageal body and the lower esophageal sphincter is discriminant between non-lupus CTD and SLE; and iii) RP may be regarded as a condition pathogenetically unrelated to manometrically detected esophageal motor abnormalities.


Subject(s)
Esophageal Motility Disorders/complications , Rheumatic Diseases/complications , Adolescent , Adult , Aged , Child , Esophageal Motility Disorders/epidemiology , Esophageal Motility Disorders/physiopathology , Esophagogastric Junction/physiopathology , Esophagus/physiopathology , Female , Humans , Male , Manometry , Middle Aged , Prevalence , Rheumatic Diseases/physiopathology
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