Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Paediatr Anaesth ; 25(12): 1294-7, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26126598

ABSTRACT

Despite leukoreduced red blood cells (LR-RBCs) reducing the risk of transfusion-related acute lung injury (TRALI), we present a case of a 16-year-old female with kyphosis who received a transfusion of one unit of LR-RBCs, which lead to life-threatening, intraoperative TRALI. The clinical presentation included pulmonary edema, severe postoperative lactic acidosis, left ventricular dysfunction, increased creatine phosphokinase, fatty infiltration of the liver, and hemodynamic instability requiring inotropic support. This presentation is not the classic description of TRALI. Our patient improved with supportive treatment and was successfully extubated on postoperative day 4. TRALI work-up revealed antibody formation to HLA A2, A68, B44, and DQA 5 for the LR-RBCs unit administered.


Subject(s)
Acute Lung Injury/etiology , Erythrocyte Transfusion/adverse effects , Spine/surgery , Acute Lung Injury/therapy , Adolescent , Antibody Formation , Female , Humans , Intraoperative Complications/etiology , Intraoperative Complications/therapy , Kyphosis/surgery
2.
Spine J ; 15(6): 1422-31, 2015 Jun 01.
Article in English | MEDLINE | ID: mdl-25796355

ABSTRACT

BACKGROUND CONTEXT: Risk factors for surgical site infection (SSI) in children derived from the studies in the adult population are potentially misleading because of differences in pathophysiology and management. PURPOSE: This systematic review addresses the key question: What are the risk factors for SSI in pediatric patients undergoing scoliosis surgery? STUDY DESIGN: This is a qualitative systematic literature review. PATIENT SAMPLE: Retrospective and observational trials of children undergoing scoliosis surgery reported on the occurrence of risk factors for SSI and the occurrence of SSI. METHODS: Pubmed (Medline), Ovid Evidence-Based Medicine Reviews (EBMR), Scopus, and Cumulative Index to Nursing and Allied Health (CINAHL) were searched electronically for relevant articles in all the languages between January 1, 1991 and August 27, 2012, and cross-references were checked. Two independent reviewers identified articles and appraised quality with the Agency for Healthcare Research and Quality (AHRQ) criteria based on a weighted scoring of 0 to 100. RESULTS: Our search identified 135 abstracts and 14 studies meeting the inclusion criteria. The AHRQ grading showed that five articles were high quality with a score of greater than 67, and five articles were moderate quality with a score between 50 and 67. The percent agreement between the two independent reviewers was 84%, and kappa agreement score was 0.91 (95% confidence interval [CI]: 0.78-1.03). There were 76 risk factors identified, of which 22 factors were reported in more than one study. Odds ratios and 95% CIs were reported inconsistently. Pooled p analysis of high- and moderate-quality articles identified five risk factors predictive of SSI: inappropriate antibiotic use (p=.001), neuromuscular scoliosis (p=.014), instrumentation (p=.023), increased hospital stay days (p=.003), and residual postoperative curve (p=.003). CONCLUSIONS: The systematic review identified inappropriate antibiotic use, neuromuscular scoliosis, instrumentation, increased hospital stay days, and residual postoperative curve as risk factors for SSI after pediatric scoliosis surgery.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Inappropriate Prescribing/statistics & numerical data , Length of Stay/statistics & numerical data , Scoliosis/surgery , Surgical Wound Infection/epidemiology , Adolescent , Child , Child, Preschool , Humans , Infant , Neuromuscular Diseases/complications , Risk Factors , Scoliosis/etiology , United States
SELECTION OF CITATIONS
SEARCH DETAIL
...