ABSTRACT
We are presenting the immunologic pattern of 100 patients with kidney transplant made from 1990-2000 at CHM CSS Dr.AAM. Eighty nine were alive related donors. Most of them were from blood group O, donors and receptors. They came from Panama, Chiriqui and Colon. Many of the donors were siblings. The grades of compatibility in frequency were D, C, A & B. For locus HLA-A the most common gen was A2 for transplanted patients and for the rest of the Panamanian population is A24. For the locus HLA-B were B35 and B38 respectively and for the locus HLA-C the most common gen was C4, and C3 for the rest of the population.
Subject(s)
HLA Antigens/analysis , Kidney Transplantation/immunology , Female , Humans , MaleABSTRACT
It is presented the experience with 90 patients receiving Eritropoietin s.c. and oral iron who were in chronic haemodialysis. After basic laboratories, including iron kinetic, in all of them was stopped oral iron and started i.v. iron 60 mgs per week, but keeping the same eritropoietin doses. The results showed an increased haemoglobin level from 6.5 to 11 g/dl mean values and a decreased doses of eritropoietin between 25 to 50%. This represent an important elevation of haemoglobin levels at a significant low cost
Subject(s)
Humans , Adolescent , Adult , Middle Aged , Anemia, Iron-Deficiency , Erythropoietin/administration & dosage , Erythropoietin/economics , Iron/administration & dosage , Hemoglobins/analysis , Hemoglobins/economics , Renal Insufficiency, Chronic/complications , Costs and Cost Analysis , Chronic Disease , Injections, IntravenousABSTRACT
It is presented the experience with 90 patients receiving Eritropoietin s.c. and oral iron who were in chronic haemodialysis. After basic laboratories, including iron kinetic, in all of them was stopped oral iron and started i.v. iron 60 mgs per week, but keeping the same eritropoietin doses. The results showed an increased haemoglobin level from 6.5 to 11 g/dl mean values and a decreased doses of eritropoietin between 25 to 50%. This represent an important elevation of haemoglobin levels at a significant low cost.
Subject(s)
Anemia, Iron-Deficiency/drug therapy , Anemia, Iron-Deficiency/etiology , Erythropoietin/administration & dosage , Erythropoietin/economics , Hemoglobins/analysis , Hemoglobins/economics , Iron/administration & dosage , Kidney Failure, Chronic/complications , Adolescent , Adult , Chronic Disease , Costs and Cost Analysis , Humans , Injections, Intravenous , Middle AgedABSTRACT
End stage renal disease patients is a serious problem all around the world. The number of patients and the cost of treatment are increasing. Kidney transplantation is the only alternative to solve the problem. In Panama, kidney transplantation is performed since 1990. At the present time 55 living related donors transplantations have been performed. It is necessary to increase the number of transplantations and to begin the cadaveric donor transplant program.
Subject(s)
Kidney Failure, Chronic/surgery , Kidney Transplantation , Costs and Cost Analysis , Humans , Kidney Failure, Chronic/economics , Kidney Transplantation/economics , PanamaABSTRACT
Erythropoietin (EP) injected subcutaneously (SC) 2 or 3 times a week, respectively, or intravenously (IV) 3 times a week, increased the hemoglobin and the hematocrit of all the patients so treated. The total units of EP used was less when it was administered SC. EP once or twice a week, respectively, administered SC also increased the hemoglobin and hematocrit in each case, and the total amount of EP used was also less
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Anemia/therapy , Renal Dialysis/adverse effects , Erythropoietin/administration & dosage , Renal Insufficiency, Chronic/blood , Anemia/blood , Anemia/etiology , Drug Administration Schedule , Hematocrit , Hemoglobin A , Renal Insufficiency, Chronic/therapy , Injections, IntravenousABSTRACT
Erythropoietin (EP) injected subcutaneously (SC) 2 or 3 times a week, respectively, or intravenously (IV) 3 times a week, increased the hemoglobin and the hematocrit of all the patients so treated. The total units of EP used was less when it was administered SC. EP once or twice a week, respectively, administered SC also increased the hemoglobin and hematocrit in each case, and the total amount of EP used was also less.
Subject(s)
Anemia/therapy , Erythropoietin/administration & dosage , Kidney Failure, Chronic/blood , Renal Dialysis/adverse effects , Adult , Anemia/blood , Anemia/etiology , Drug Administration Schedule , Female , Hematocrit , Hemoglobin A , Humans , Injections, Intravenous , Kidney Failure, Chronic/therapy , Male , Middle AgedABSTRACT
The authors determined the frequency of genes and haplotypes of the HLA system in 965 panamanian men and women not related to each other, between 6 and 65 years of age. The HLA-A locus genes with the highest frequency (f) were A2, with f 0.1763; A24, f 0.1584; A30, f 0.1340; A23, f 0.1069; A3, f 0.0774. The other 20 genes each had less than 0.07. The genes with the highest frequency for locus HLA-B were B35, f 0.1946; B44, f 0.0904; B7, f 0.0774; B60 and B61, f 0.0582. For locus HLA-C, the most frequent genes were Cw3 with f 0.1549 and Cw4, f 0.1444. For locus HLA-DR, the most frequent genes were DR2 with f 0.1283; DR3, f 0.0620; DR7, f 0.0409. The most frequent haplotypes in the panamanian population were A2-B35 with f 0.0382; A3-B35, f 0.0191; A24-35, f 0.0287; A24-B61, f 0.0239; A29-B44, f 0.0287; A30-B42, f 0.0239; A23-B44, f 0.0191; A1-B8, f 0.0143. The authors conclude that the panamanian population exhibits a high degree of polymorphism for loci HLA-A, B and C, while for locu HLA-DR the frequency is the median when compared with that in caucasian, negro and oriental groups; and that, according to locus, predominant genes originating from these groups and found, corroborating the multiracial origen of the panamanian population.
Subject(s)
Gene Frequency , HLA Antigens/genetics , Haplotypes , Adolescent , Adult , Child , Female , HLA-A Antigens/genetics , HLA-B Antigens/genetics , Histocompatibility Testing , Humans , Male , Middle Aged , Panama , Polymorphism, GeneticABSTRACT
The authors determined the frequency of genes and haplotypes of the HLA system in 965 panamanian men and women not related to each other, between 6 and 65 years of age. The HLA-A locus genes with the highest frequency (f) were A2, with f 0.1763; A24, f 0.1584; A30, f 0.1340; A23, f 0.1069; A3, f 0.0774. The other 20 genes each had less than 0.07. The genes with the highest frequency for locus HLA-B were B35, f 0.1946; B44, f 0.0904; B7, f 0.0774; B60 and B61, f 0.0582. For locus HLA-C, the most frequent genes were Cw3 with f 0.1549 and Cw4, f 0.1444. For locus HLA-DR, the most frequent genes were DR2 with f 0.1283; DR3, f 0.0620; DR7, f 0.0409. The most frequent haplotypes in the panamanian population were A2-B35 with f 0.0382; A3-B35, f 0.0191; A24-35, f 0.0287; A24-B61, f 0.0239; A29-B44, f 0.0287; A30-B42, f 0.0239; A23-B44, f 0.0191; A1-B8, f 0.0143. The authors conclude that the panamanian population exhibits a high degree of polymorphism for loci HLA-A, B and C, while for locu HLA-DR the frequency is the median when compared with that in caucasian, negro and oriental groups; and that, according to locus, predominant genes originating from these groups and found, corroborating the multiracial origen of the panamanian population
