Sociodemographic and clinical variables as predictors of the diagnostic characteristics of first episodes of schizophrenia.

This paper examines the association of clinical and sociodemographic factors, including age and sex, with the diagnostic characteristics of first episodes of schizophrenia. The study included all patients with a first episode of schizophrenia who made contact with any of the public mental health services of the Autonomous Region of Cantabria in Northern Spain over a period of 2 years. Diagnostic characteristics were determined using the Spanish version of the Present State Examination (PSE-9), and the Scales for the Assessment of Positive and Negative Symptoms (SAPS and SANS, respectively). The study confirms that the onset of schizophrenia tends to occur earlier in men than in women. However, neither sex nor age of onset were found to be associated with the clinical and psychopathological characteristics of the patients as established by the PSE-CATEGO-ID system. Furthermore, no other factors were found to be associated with these diagnostic characteristics. Being female, having a family history of mental illness, and a poor premorbid adjustment were found to predict negative symptoms as defined by SANS/SAPS scales.

Patterns of positive and negative symptoms in first episode schizophrenia.

BACKGROUND: The aim is to examine, in first episodes of schizophrenia, the appropriateness of the simple two-dimensional model of schizophrenia ('negative' and 'positive' dimensions) and more complex variants. METHOD: All patients with a first episode of schizophrenia who, over a two-year period, made contact with any of the public mental health services of the autonomous region of Cantabria in northern Spain were investigated. The psychiatric evaluation included, among other instruments, the Present State Examination (PSE-9), and the scales for the assessment of the 'positive' and 'negative' symptoms of schizophrenia (SAPS and SANS respectively). The dimensionality of the SAPS/SANS item scores and sub-scales was examined throughout the use of principal component analysis. RESULTS: The principal component solution that best fits the data obtained with the initial SANS/SAPS sub-scales reflects the existence of three different ('negative', 'positive', 'disorganisation') factors. The strategy adopted of repeating the analysis after extracting the principal components of the original sub-scales, revealed that although the nature and item composition of the initial 'negative' and 'disorganisation' factors were in general confirmed, the 'positive' dimension presented a more complex structure with at least two 'positive' ('Non-Paranoid' and 'Paranoid') independent factors. CONCLUSION: The psychopathological structure of the early stages of schizophrenia, as evaluated by the SANS/SAPS, is characterised by the presence of four dimensions: two 'positive', one 'negative' and one 'disorganisation'.

Structural abnormalities of the brain in schizophrenia: sex differences in the Cantabria First Episode of Schizophrenia Study.

This paper examines structural brain abnormalities, as evaluated by the CT scan, in first episodes of schizophrenia and their association with sociodemographic, diagnostic and clinical variables. The investigation included all patients with a first episode of schizophrenia who, over a 2-year period, made contact with any of the public mental health services of the Autonomous Region of Cantabria in Northern Spain. Diagnostic and clinical characteristics were evaluated through the use of the Spanish version of the Present State Examination (PSE-9) and the Scales for the Assessment of Positive and Negative Symptoms (SANS and SAPS respectively). The study demonstrated the presence of structural brain abnormalities in this sample of first episode schizophrenics. These abnormalities were mainly expressed in the presence of larger VBR for schizophrenic patients than in the controls, these findings being more marked in women than in men. We failed to reveal, however, any evidence of an association of these brain abnormalities with diagnostic or clinical characteristics.

The Cantabria first episode schizophrenia study: a summary of general findings.

This article describes the general findings of the initial cross-sectional stage of a prospective follow-up study of all first episodes of schizophrenia that occurred in the Autonomous Community of Cantabria over a 2-year period and that established contact with any mental health service. The project comprises: i) a 2-year cross-sectional stage, in which the sample was gathered and studied with structured psychiatric instruments such as the Present State Examination and the Scales for the Assessment of Negative and Positive Symptoms (SANS and SAPS), and; ii) a continuous follow-up. We detected, in the risk age ranged of 15-54 years, an incidence of 1.9 per 10,000 inhabitants per year for schizophrenia and of 1.3 per 10,000 inhabitants per year for the S+ CATEGO diagnosis, without any significant gender difference of morbidity. The mean age for the total schizophrenic population was 26 years, being significantly higher in women than in men. In contrast with what happens with marital status, type of household or urban/rural way of life, there was no gender difference in relation to the other sociodemographic variables. The way in which nosological and clinical variables are associated with first episodes of schizophrenia was also examined in this study. We found that 75% of patients reached a maximum CATEGO-ID level, 71% received a S+ CATEGO diagnosis, 59% presented first-rank symptoms of schizophrenia and that the percentage of a schizophrenic negative syndrome, as identified by the SANS and SAPS, was very low.(ABSTRACT TRUNCATED AT 250 WORDS)

[Development and verification of the Spanish version of the "scanning system" psychiatric interview ("Questionnaires for clinical evaluation in neuropsychiatry"]. / Desarrollo y verificación de la versión española de la entrevista psiquiátrica "sistema scan" ("cuestionarios para la evaluación clínica en neuropsiquiatria").

The SCAN System (Schedules for Clinical Assessment in Neuropsychiatry) represents the latest stage in a 30 year line of development. It is a set of instruments aimed at assessing, measuring and classifying the psychopathology and behaviour associated with the mayor psychiatric disorders of adult life. The SCAN System has several components: the SCAN interview, the Glossary of differential definitions, the CATEGO5 program and the CAPSE (Computer Assisted PSE versión). This latest element is a computerised versión of the System, combining the SCAN's interview, Glossary and CATEGO5. The SCAN interview has 3 components, the tenth edition of the Present State Examination (PSE10), the Item Group Checklist (IGC) and the Clinical History Schedule (CHS), whose main features are described in the paper. The CATEGO5 suite of computer programs consists in a set of utilities concerned with data entry and diagnosis. The Entry program is used to enter data recorded manually during a SCAN interview and the diagnosis programs derive diagnosis according to ICD-10 and DSM-III-R/DSM-IV criteria. This report analyses the main methods and results of the "Field Trials" that took place in 20 Centres of different countries. These studies showed that the diagnosis and symptoms scores have a high degree of reliability and that this is also applicable to the spanish version. In conclusion, we consider that the SCAN System is once of the more suitable psychiatric diagnostic instruments currently available.

[Factors implicated in the "routes of care" in mental health]. / Factores implicados en las "rutas asistenciales" en salud mental.

We analyze in this paper the way in which different sociodemographic and clinical factors influence, in different health areas of Cantabria (Spain), the pathways taken for patients suffering from "new psychiatric illness". The work is part of a Multicentric International Research Project developed by the World Health Organization aimed at evaluating and improving the quality of mental health care in different centres of the world. The general pathway to mental health services, in Cantabria, is dominated by the general practitioner (54.3%) and by the "hospital doctor/medical specialist" (26.4%), been therefore similar to the one found in other Spanish speaking centres, like Granada and Cuba; the differences are, however, much larger with the one found in Mexico city. It is also, possible to observe in our data that the pathways are influenced by clinical factors, among which the more relevant one is one related to the characteristics of the psychopathology. Thus in general we found that two factors like, the presence of "psycho-organic" syndromes and the severity of the psychopathology appears to influence: i) the degree of complexity of the pathway, which is higher in the "psycho-organic" and in the more severe forms of psychiatric disorders; ii) the protagonist which assumes, in detriment of the general practitioner, other "helping agencies" which is also increased in the "organic" and more severe disorders. We also found that other aspects like: the act of establishing "contact" with services, the delay in the obtention of help, and the prescription of psychotropic medicines, were also influenced by different sociodemographic, clinical and service related variables.