ABSTRACT
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ABSTRACT
OBJECTIVE: To study the clinical significance of expressions of tumor necrosis factor receptor I and II(TNFR I and II) and their relationship with clinical pathology in human gastric carcinoma. METHODS: SABC immunohistochemical method was used to examine the expressions of TNFR I and II in 51 cases of gastric carcinoma, 41 adjacent mucosal and 15 normal gastric mucosa tissues. RESULTS: The positivity rates of TNFR I and II expressions in human gastric carcinoma were significantly higher than those in the adjacent mucosal and normal mucosal tissues, and their expressions were significantly higher in the surrounding mucosa than in the normal tissues. In gastric carcinoma tissues, no correlations of TNFR I and II expressions with serous membrane invasion or lymph node metastasis were found, but the differentiation grade was positively correlated with TNFR expressions (r=-0.3111, P=0.035; r=-0.5952, P=0.000, respectively). CONCLUSION: TNFR I and II expressions are valuable indicators for determining the malignancy and predicting the differentiation grade of gastric carcinoma.
