LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway.

Long noncoding RNA (lncRNA) plays crucial roles in the development of gastric cancer (GC); however, studies of their mechanisms of action are needed to determine their clinical value. The aim of this study is to explore the effects and mechanisms of THUMPD3-AS1 in GC. Elevated levels of THUMPD3-AS1 were observed in GC and demonstrated a significant positive correlation with poor prognosis. Functionally, THUMPD3-AS1 promoted GC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and induced tumor growth in vivo. THUMPD3-AS1 exerts its regulatory function on BCAT1 through competitive binding with miR-1297. Further investigations confirmed that both THUMPD3-AS1 and miR-1297 interact with BCAT1. These findings suggest that THUMPD3-AS1 promotes GC invasion and EMT by regulating the miR-1297/BCAT1 pathway, indicating that THUMPD3-AS1 may serve as a biomarker and therapeutic target for GC.

Erratum: LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway.

[This corrects the article DOI: 10.1016/j.isci.2023.107673.].

Tailoring planar slip to achieve pure metal-like ductility in body-centred-cubic multi-principal element alloys.

Uniform tensile ductility (UTD) is crucial for the forming/machining capabilities of structural materials. Normally, planar-slip induced narrow deformation bands localize the plastic strains and hence hamper UTD, particularly in body-centred-cubic (bcc) multi-principal element high-entropy alloys (HEAs), which generally exhibit early necking (UTD < 5%). Here we demonstrate a strategy to tailor the planar-slip bands in a Ti-Zr-V-Nb-Al bcc HEA, achieving a 25% UTD together with nearly 50% elongation-to-failure (approaching a ductile elemental metal), while offering gigapascal yield strength. The HEA composition is designed not only to enhance the B2-like local chemical order (LCO), seeding sites to disperse planar slip, but also to generate excess lattice distortion upon deformation-induced LCO destruction, which promotes elastic strains and dislocation debris to cause dynamic hardening. This encourages second-generation planar-slip bands to branch out from first-generation bands, effectively spreading the plastic flow to permeate the sample volume. Moreover, the profuse bands frequently intersect to sustain adequate work-hardening rate (WHR) to large strains. Our strategy showcases the tuning of plastic flow dynamics that turns an otherwise-undesirable deformation mode to our advantage, enabling an unusual synergy of yield strength and UTD for bcc HEAs.

Phosphorylation of Li-Rich Mn-Based Layered Oxides for Anion Redox and Structural Stability.

Li-rich Mn-based layered oxides are proposed to be candidates for high-energy Li-ion batteries. However, their large-scale production is still hampered by poor rate capability and severe voltage decay. It was mainly attributed to the irreversible oxygen loss, which induces transition metal ion migration, electrolyte consumption, and structural evolution. Herein, we propose an effective strategy of phosphorylation, in which the phosphate ion is induced to remove the surface labile oxygen. It urges the Li2MnO3 component to transform to the spinel-like structure and promotes the anionic redox process, thus facilitating lithium-ion diffusion and improving structural stability. As a result, the Li2MnO3 component is more prone to be activated, with the capacity increased by 18% in comparison with the pristine one. It also exhibits a superior capacity retention of 86.1% after 150 extended cycles and better rate performance delivering a capacity of 148.1 mA h g-1 even at 10 C. The effective phosphorylation opens a new way to tune anion redox chemistry and obtain structurally stable materials.

Scalable Nitrate Treatment for Constructing Integrated Surface Structures to Mitigate Capacity Fading and Voltage Decay of Li-Rich Layered Oxides.

Capacity fading and voltage decay is one of the biggest obstacles for the practical application of Li-rich layered oxides due to the serious surface-related detrimental reactions. Herein, we develop a versatile and scalable method to construct a robust surface-integrated structure. All the designed samples deliver outstanding capacity and voltage stability, among which the Zn-treated sample possesses the best electrochemical performance. Its capacity retention is larger than 90 % after 400 cycles with a voltage decay ratio as small as 0.73 mV per cycle. What is more, the rules of surface-integrated structure with different cations in terms of capacity and voltage stability is further deciphered by combining with density function theory (DFT) calculations. It is found that to obtain advanced Li-rich layered oxide cathodes, cations in Li-sites should firstly ensure the binding energy of the surface-integrated structure in a lower level and then provide Bader charge for the nearest O atoms as small as possible.

Deciphering the effects of hexagonal and monoclinic structure distribution on the properties of Li-rich layered oxides.

Uniform distribution of Li2MnO3 and LiMO2 components in a Co-free Li-rich layered oxide is achieved by treating precursors with NH3·H2O, which expands the lattice parameter and promotes the activation of Li2MnO3, resulting in excellent electrochemical performance. What's more, it also contributes to the storage stability of Li-rich layered oxides.

A general route of fluoride coating on the cyclability regularity of high-voltage NCM cathodes.

The effect of fluoride coatings, an effective approach to suppress HF corrosion, on the cycling stability of NCM523 cathodes is systematically studied. It is the first study to reveal that fluoride coatings significantly restrain interfacial reactions when, simultaneously, the fluoride suspension possesses an appropriate pH (near 4.0) and there is a small cation ionic radius.

An Ultra-Long-Life Lithium-Rich Li1.2 Mn0.6 Ni0.2 O2 Cathode by Three-in-One Surface Modification for Lithium-Ion Batteries.

Voltage decay and capacity fading are the main challenges for the commercialization of Li-rich Mn-based layered oxides (LLOs). Now, a three-in-one surface treatment is designed via the pyrolysis of urea to improve the voltage and capacity stability of Li1.2 Mn0.6 Ni0.2 O2 (LMNO), by which oxygen vacancies, spinel phase integration, and N-doped carbon nanolayers are synchronously built on the surface of LMNO microspheres. Oxygen vacancies and spinel phase integration suppress irreversible O2 release and help lithium ion diffusion, while N-doped carbon nanolayer mitigates the corrosion of electrolyte with excellent conductivity. The electrochemical performance of LMNO after the treatment improves significantly; the capacity retention rate after 500 cycles at 1 C is still as high as 89.9 % with a very small voltage fading rate of 1.09 mV cycle-1 . This three-in-one surface treatment strategy can suppress the voltage decay and capacity fading of LLOs.