ABSTRACT
OBJECTIVE: To investigate the potential application of α-1 blocker (urapidil) in the treatment of lower urinary tract symptoms (LUTS) in male patients with benign prostatic hypertrophy (BPH), we conducted a comprehensive meta-analysis. METHODS: Our study involved identifying and collecting randomized controlled trials (RCT) and clinical observational studies from databases including PubMedãMEDLINEãWeb of scienceãCNKI and Wanfang database. We performed meta-analysis using RevMan 5.2.0 software for both fixed effects model and random effects model. RESULTS: Our analysis included 3 short-term (within 1 month) observational studies and 1 RCT involving 142 patients. We found that urapidil significantly improved the International Prostate Symptom Score (IPSS, MD=ï¼5.57, 95%CI: ï¼7.98ï½ï¼3.16ï¼P<0.00001), nocturiaï¼MD=ï¼0.7, 95%CI: ï¼1.16ï½ï¼0.24ï¼P=0.003ï¼, residual urine rateï¼MD=ï¼6.97ï¼95%CI: ï¼12.57ï½ï¼1.37ï¼P=0.01ï¼, average flow rateï¼MD=2.04ï¼95%CI: 0.52ï½3.56ï¼P=0.008ï¼, and maximum flow rate ï¼MD=4.29ï¼95%CI: 0.58ï½8.01ï¼P=0.02ï¼of patients. However, there was no significant difference in the residual urine volumeï¼MD=ï¼35.93ï¼95%CI: ï¼78.62ï½6.76ï¼P=0.10ï¼between pre-treatment and post-treatment groups. CONCLUSION: Urapidil is an effective medication for relieving LUTS in BPH patients. However, due to the limited quantity and quality of current RCT studies, high-quality and large-scale RCT studies are still needed to further confirm this conclusion.