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1.
Anti-oncostatin M antibody puts brakes on asthma exacerbations.
Cully, Megan.
Nat Rev Drug Discov ; 21(3): 178, 2022 03.
Article in English | MEDLINE | ID: mdl-35110748

Subject(s)
Asthma , Asthma/drug therapy , Asthma/immunology , Humans
2.
A novel antibiotic from a bacterial arms race.
Cully, Megan.
Nat Rev Drug Discov ; 21(2): 98, 2022 02.
Article in English | MEDLINE | ID: mdl-35017744

Subject(s)
Anti-Bacterial Agents , Drug Resistance, Bacterial , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Bacteria/drug effects , Drug Resistance, Bacterial/drug effects , Humans
3.
Antihistamines boost immunotherapy.
Cully, Megan.
Nat Rev Cancer ; 22(2): 69, 2022 02.
Article in English | MEDLINE | ID: mdl-34903891

Subject(s)
Histamine Antagonists , Immunotherapy , Humans
4.
A tale of two antiviral targets - and the COVID-19 drugs that bind them.
Cully, Megan.
Nat Rev Drug Discov ; 21(1): 3-5, 2022 01.
Article in English | MEDLINE | ID: mdl-34857884

Subject(s)
Antiviral Agents/therapeutic use , COVID-19 Drug Treatment , COVID-19/immunology , Humans , SARS-CoV-2/drug effects , SARS-CoV-2/immunology , Vaccines/immunology
5.
Anti-histamines boost immunotherapy.
Cully, Megan.
Nat Rev Drug Discov ; 21(1): 17, 2022 01.
Article in English | MEDLINE | ID: mdl-34862488

Subject(s)
Immunologic Factors , Immunotherapy , Humans
6.
Degrading disease-causing RNA in ALS.
Cully, Megan.
Nat Rev Drug Discov ; 20(12): 897, 2021 12.
Article in English | MEDLINE | ID: mdl-34732854

Subject(s)
Amyotrophic Lateral Sclerosis , Motor Neurons/metabolism , Proteolysis/drug effects , Amyotrophic Lateral Sclerosis/genetics , Amyotrophic Lateral Sclerosis/therapy , Animals , Disease Models, Animal , Humans , Introns/genetics , Molecular Targeted Therapy , RNA Stability/drug effects , Ribonucleases/antagonists & inhibitors
7.
A novel single-agent antibiotic.
Cully, Megan.
Nat Rev Microbiol ; 19(12): 743, 2021 12.
Article in English | MEDLINE | ID: mdl-34594016

Subject(s)
Cystic Fibrosis , Respiratory Tract Infections , Anti-Bacterial Agents/pharmacology , Humans
8.
A novel single-agent antibiotic.
Cully, Megan.
Nat Rev Drug Discov ; 20(11): 814, 2021 11.
Article in English | MEDLINE | ID: mdl-34556837

Subject(s)
Cystic Fibrosis , Respiratory Tract Infections , Anti-Bacterial Agents , Humans
9.
Promoting APRIL interaction to control atherosclerosis.
Cully, Megan.
Nat Rev Drug Discov ; 20(10): 740, 2021 10.
Article in English | MEDLINE | ID: mdl-34475542

Subject(s)
Atherosclerosis , Tumor Necrosis Factor Ligand Superfamily Member 13 , Atherosclerosis/drug therapy , Atherosclerosis/prevention & control , Humans
10.
T cell-regulating therapies for autoimmune diseases take FDA rejection in stride.
Cully, Megan.
Nat Rev Drug Discov ; 20(9): 655-657, 2021 09.
Article in English | MEDLINE | ID: mdl-34363024

Subject(s)
Autoimmune Diseases/therapy , Drug Approval/legislation & jurisprudence , T-Lymphocytes/immunology , Animals , Antibodies, Monoclonal, Humanized/pharmacology , Autoimmune Diseases/immunology , Autoimmune Diseases/physiopathology , Drug Industry/legislation & jurisprudence , Humans , United States , United States Food and Drug Administration
11.
Broadly neutralizing anti-coronavirus antibodies.
Cully, Megan.
Nat Rev Drug Discov ; 20(9): 665, 2021 09.
Article in English | MEDLINE | ID: mdl-34316026

Subject(s)
Broadly Neutralizing Antibodies/immunology , COVID-19/immunology , SARS-CoV-2/immunology , COVID-19/virology , Humans , Mutation , SARS-CoV-2/genetics
12.
Antiviral therapy targets latent HSV infections.
Cully, Megan.
Nat Rev Drug Discov ; 20(8): 586, 2021 08.
Article in English | MEDLINE | ID: mdl-34175893

Subject(s)
Antiviral Agents , Antiviral Agents/therapeutic use , Humans
13.
A protease with far-reaching anti-cancer effects.
Cully, Megan.
Nat Rev Drug Discov ; 20(7): 505, 2021 07.
Article in English | MEDLINE | ID: mdl-34103698

Subject(s)
Neoplasms , Peptide Hydrolases , Drug Discovery , Humans , Neoplasms/drug therapy
14.
METTLing with RNA methylation in leukaemia.
Cully, Megan.
Nat Rev Drug Discov ; 20(6): 423, 2021 06.
Article in English | MEDLINE | ID: mdl-33907314

Subject(s)
Leukemia , Humans , Leukemia/drug therapy , Leukemia/genetics , Methylation , RNA
15.
Preserving insulin signalling in ß-cells.
Cully, Megan.
Nat Rev Drug Discov ; 20(4): 262, 2021 04.
Article in English | MEDLINE | ID: mdl-33580205

Subject(s)
Insulin-Secreting Cells , Insulin , Blood Glucose , Signal Transduction
16.
Teaching old brains new immune tricks.
Cully, Megan.
Nat Rev Immunol ; 21(3): 133, 2021 03.
Article in English | MEDLINE | ID: mdl-33568783
17.
In vivo base editing rescues progeria in mice.
Cully, Megan.
Nat Rev Drug Discov ; 20(2): 98, 2021 02.
Article in English | MEDLINE | ID: mdl-33441999

Subject(s)
Progeria , Animals , Mice , Phenotype , Progeria/genetics
18.
Teaching old brains new immune tricks.
Cully, Megan.
Nat Rev Drug Discov ; 20(3): 176, 2021 03.
Article in English | MEDLINE | ID: mdl-33510472

Subject(s)
Aging , Cognitive Dysfunction , Brain , Humans , Myeloid Cells
19.
Exosome-based candidates move into the clinic.
Cully, Megan.
Nat Rev Drug Discov ; 20(1): 6-7, 2021 01.
Article in English | MEDLINE | ID: mdl-33311580

Subject(s)
Cell- and Tissue-Based Therapy , Clinical Trials as Topic , Drug Delivery Systems , Exosomes/chemistry , Exosomes/genetics , Exosomes/metabolism , Humans
20.
Targeted PI3K inhibitors reduce lung fibrosis in mice.
Cully, Megan.
Nat Rev Drug Discov ; 19(12): 838, 2020 12.
Article in English | MEDLINE | ID: mdl-33122814

Subject(s)
Phosphatidylinositol 3-Kinases , Pulmonary Fibrosis , Animals , Fibroblasts , Lung , Mice , Models, Theoretical , Pulmonary Fibrosis/drug therapy , TOR Serine-Threonine Kinases
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