Isolated Ocular Stevens-Johnson Syndrome Caused by Lymecycline in a Patient with Underlying Ulcerative Colitis.

Stevens-Johnson syndrome (SJS) and the more severe variant, toxic epidermal necrolysis (TEN), are a spectrum of mucocutaneous reactions with potentially devastating ocular consequences. Ocular complications occur in about 70% of patients with Stevens-Johnson syndrome, and 35% continue with chronic disease. We report an unusual presentation of isolated ocular Stevens-Johnson syndrome in a patient with recently diagnosed ulcerative colitis being treated with Infliximab. The case had an insidious and atypical onset and represented a diagnostic dilemma. The diagnosis was more difficult, due to the fact that the inciting agent had long been stopped. Severe bacterial conjunctivitis such as that caused by Chlamydia Trachomatis, Corynebacterium diphtheria, and Neisseria Gonorrhea can cause forniceal shortening and symblepharon; this diagnosis was ruled out with microbiological swabs. A conjunctival biopsy was the key to diagnosis. Treatment involved high-dose IV steroids and dual immunosuppression with Infliximab and mycophenolate mofetil. We sought to employ interventions with the greatest impacts on our patient's condition. Our experience contributes to the growing evidence supporting intensive ophthalmic management of SJS to prevent long-term vision loss.

Predictability of corneal flap thickness in laser in situ keratomileusis using a 200 kHz femtosecond laser.

PURPOSE: To compare the intended versus the resultant thickness of laser in situ keratomileusis (LASIK) flaps created with a new femtosecond laser and to report the 3-month postoperative refractive outcomes. SETTING: Wellington Eye Clinic, Dublin, Ireland. DESIGN: Retrospective consecutive case series. METHODS: A consecutive series of eyes having LASIK flaps created using a Wavelight FS200 femtosecond laser were included in this analysis. Eyes with preoperative spherical equivalent (SE) myopic refractive errors up to -12.00 diopters (D), hyperopic refractive errors up to +5.50 D, and astigmatism up to 6.00 D received primary LASIK. Outcomes included postoperative flap thickness and 3-month postoperative refraction. RESULTS: Outcomes in 431 eyes of 258 patients having LASIK with femtosecond flap creation were assessed. With an intended flap thickness of 120 µm, the mean post-LASIK flap thickness was 120.23 µm ± 13.94 (SD). In 349 of 813 eyes, EX500 optical pachymetry measurements were compared with Scheimpflug pachymetry readings. The mean corneal thickness was 553.52 ± 29.81 µm with optical pachymetry and 553.39 ± 29.12 µm with the Pentacam rotating Scheimpflug camera. In 162 eyes, the flap thickness was measured with optical coherence tomography; the mean was 121.94 ± 10.52 µm. Achieved flap dimensions were as intended. CONCLUSIONS: This study provides evidence of the predictability and lower variability of LASIK flaps created using the femtosecond laser. Consecutive patients having LASIK had good, predictable, and stable outcomes at the 3-month mark.