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Antifungal activity of sterols and triterpenes isolated from Ganoderma annulare.

Smania, E F A; Delle Monache, F; Smania, A; Yunes, R A; Cuneo, R S.

Fitoterapia ; 74(4): 375-7, 2003 Jun.

Article in English | MEDLINE | ID: mdl-12781809

ABSTRACT

Three sterols, 5alpha-ergost-7-en-3beta-ol, 5alpha-ergosta-7,22-dien-3beta-ol and 5,8-epidioxy-5alpha,8alpha-ergosta-6,22-dien-3beta-ol and five triterpenes, applanoxidic acids A, C, F, G and H, have been isolated from Ganoderma annulare. The applanoxidic acids A, C and F were found to inhibit the growth of the fungi Microsporum cannis and Trichophyton mentagrophytes at concentrations of 500 to 1000 microg/ml.

Subject(s)

Antifungal Agents/pharmacology , Ganoderma , Microsporum/drug effects , Phytotherapy , Plant Extracts/pharmacology , Trichophyton/drug effects , Antifungal Agents/administration & dosage , Antifungal Agents/therapeutic use , Dose-Response Relationship, Drug , Humans , Microbial Sensitivity Tests , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Sterols/administration & dosage , Sterols/pharmacology , Sterols/therapeutic use , Triterpenes/administration & dosage , Triterpenes/pharmacology , Triterpenes/therapeutic use , Wood

ABSTRACT

Subject(s)

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